19期

最新文章

• Strigolactones promote flowering by inducing the miR319- LA- SFT module in tomato AI翻译
  作者：Visentin, Ivan; Ferigolo, Leticia Frizzo; Russo, Giulia; Krukowski, Paolo Korwin; Capezzali, Caterina; Tarkowska, Danuse; Gresta, Francesco; Deva, Eleonora; Nogueira, Fabio Tebaldi Silveira; Schubert, Andrea; Cardinale, Francesca
  作者单位：University of Turin; Universidade de Sao Paulo; Palacky University Olomouc; Czech Academy of Sciences; Institute of Experimental Botany of the Czech Academy of Sciences; University of Milan
  摘要：Strigolactones are a class of phytohormones with various functions in plant development, stress responses, and in the interaction with (micro)organisms in the rhizosphere. While their effects on vegetative development are well studied, little is known about their role in reproduction. We investigated the effects of genetic and chemical modification of strigolactone levels on the timing and intensity of flowering in tomato ( Solanum lycopersicum L.) and the molecular mechanisms underlying such ...
• Identification of potent pan- ephrin receptor kinase inhibitors using DNA- encoded chemistry technology AI翻译
  作者：Madasu, Chandrashekhar; Liao, Zian; Parks, Sydney E.; Sharma, Kiran L.; Bohren, Kurt M.; Ye, Qiuji; Li, Feng; Palaniappan, Murugesan; Tan, Zhi; Yuan, Fei; Creighton, Chad J.; Tang, Suni; Masand, Ramya P.; Guan, Xiaoming; Young, Damian W.; Monsivais, Diana; Matzuk, Martin M.
  作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine
  摘要：EPH receptors (EPHs), the largest family of tyrosine kinases, phosphorylate downstream substrates upon binding of ephrin cell surface-associated ligands. In a large cohort of endometriotic lesions from individuals with endometriosis, we found that EPHA2 and EPHA4 expressions are increased in endometriotic lesions relative to normal eutopic endometrium. Because signaling through EPHs is associated with increased cell migration and invasion, we hypothesized that chemical inhibition of EPHA2/4 co...
• Bridging the gap between models based on ordinary, delayed, and fractional differentials equations through integral kernels AI翻译
  作者：Monteiro, Noemi Zeraick; dos Santos, Rodrigo Weber; Mazorche, Sandro Rodrigues
  作者单位：Universidade Federal de Juiz de Fora; Universidade Federal de Juiz de Fora
  摘要：Evolution equations with convolution -type integral operators have a history of study, yet a gap exists in the literature regarding the link between certain convolution kernels and new models, including delayed and fractional differential equations. We demonstrate, starting from the logistic model structure, that classical, delayed, and fractional models are special cases of a framework using a gamma Mittag-Leffler memory kernel. We discuss and classify different types of this general kernel, ...
• Catalysis driven by an amyloid-substrate complex AI翻译
  作者：Sawazaki, Taka; Sasaki, Daisuke; Sohma, Youhei
  作者单位：Wakayama Medical University
  摘要：Amine modification through nucleophilic attack of the amine functionality is a very common chemical transformation. Under biorelevant conditions using acidic- to- neutral pH buffer, however, the nucleophilic reaction of alkyl amines (pKa approximate to 10) is not facile due to the generation of ammonium ions lacking nucleophilicity. Here, we disclose a unique molecular transformation system, catalysis driven by amyloid-substrate complex (CASL), that promotes amine modifications in acidic buffe...
• Nonreciprocity and odd viscosity in chiral active fluids AI翻译
  作者：Markovich, Tomer; Lubensky, Tom C.
  作者单位：Tel Aviv University; Tel Aviv University; University of Pennsylvania
  摘要：Odd viscosity couples stress to strain rate in a dissipationless way. It has been studied in plasmas under magnetic fields, superfluid He 3 , quantum -Hall fluids, and recently in the context of chiral active matter. In most of these studies, odd terms in the viscosity obey Onsager reciprocal relations. Although this is expected in equilibrium systems, it is not obvious that Onsager relations hold in active materials. By directly coarse -graining the kinetic energy and independently using both...
• The thermoneutral zone in women takes an arctic shift compared to men AI翻译
  作者：Brychta, Robert J.; Mcgehee, Suzanne; Huang, Shan; Leitner, Brooks P.; Duckworth, Courtney J.; Fletcher, Laura A.; Kim, Katherine; Cassimatis, Thomas M.; Israni, Nikita S.; Lea, Hannah J.; Lentz, Taylor N.; Pierce, Anne E.; Jiang, Alex; Lamunion, Samuel R.; Thomas, Reed J.; Ishihara, Asuka; Courville, Amber B.; Yang, Shanna B.; Reitman, Marc L.; Cypess, Aaron M.; Chen, Kong Y.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of Health (NIH) - USA
  摘要：Conventionally, women are perceived to feel colder than men, but controlled comparisons are sparse. We measured the response of healthy, lean, young women and men to a range of ambient temperatures typical of the daily environment (17 to 31 degrees C). The Scholander model of thermoregulation defines the lower critical temperature as threshold of the thermoneutral zone, below which additional heat production is required to defend core body temperature. This parameter can be used to characteriz...
• Developing a predictive science of the biosphere requires the integration of scientific cultures AI翻译
  作者：Enquist, Brian J.; Kempes, Christopher P.; West, Geoffrey B.
  作者单位：University of Arizona; The Santa Fe Institute
  摘要：Increasing the speed of scientific progress is urgently needed to address the many challenges associated with the biosphere in the Anthropocene. Consequently, the critical question becomes: How can science most rapidly progress to address large, complex global problems? We suggest that the lag in the development of a more predictive science of the biosphere is not only because the biosphere is so much more complex, or because we do not have enough data, or are not doing enough experiments, but...
• Discovering optimal kinetic pathways for self- assembly using automatic differentiation AI翻译
  作者：Jhaveri, Adip; Loggia, Spencer; Qian, Yian; Johnson, Margaret E.
  作者单位：Johns Hopkins University
  摘要：Macromolecular complexes are often composed of diverse subunits. The self - assembly of these subunits is inherently nonequilibrium and must avoid kinetic traps to achieve high yield over feasible timescales. We show how the kinetics of self - assembly benefits from diversity in subunits because it generates an expansive parameter space that naturally improves the expressivity of self - assembly, much like a deeper neural network. By using automatic differentiation algorithms commonly used in ...
• The HSV-1 pUL37 protein promotes cell invasion by regulating the kinesin-1 motor AI翻译
  作者：Kim, Dongho; Cianfrocco, Michael A.; Verhey, Kristen J.; Smith, Gregory A.; Shenk, Thomas
  作者单位：Northwestern University; Feinberg School of Medicine; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Neurotropic alphaherpesviruses, including herpes simplex virus type 1 (HSV - 1), recruit microtubule motor proteins to invade cells. The incoming viral particle traffics to nuclei in a two - step process. First, the particle uses the dynein-dynactin motor to sustain transport to the centrosome. In neurons, this step is responsible for long - distance retrograde axonal transport and is an important component of the neuroinvasive property shared by these viruses. Second, a kinesin - dependent me...
• Human mutations in high- confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice AI翻译
  作者：Nasello, Cara; Poppi, Lauren A.; Wu, Junbing; Kowalski, Tess F.; Thackray, Joshua K.; Wang, Riley; Persaud, Angelina; Mahboob, Mariam; Lin, Sherry; Spaseska, Rodna; Johnson, C. K.; Gordon, Derek; Tissir, Fadel; Heiman, Gary A.; Tischfield, Jay A.; Bocarsly, Miriam; Tischfield, Max A.
  作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Harvard University; Harvard Medical School; Qatar Foundation (QF); Hamad Bin Khalifa University-Qatar; Universite Catholique Louvain
  摘要：Tourette disorder (TD) is poorly understood, despite affecting 1/160 children. A lack of animal models possessing construct, face, and predictive validity hinders progress in the field. We used CRISPR/Cas9 genome editing to generate mice with mutations orthologous to human de novo variants in two high - confidence Tourette genes, CELSR3 and WWC1 . Mice with human mutations in Celsr3 and Wwc1 exhibit cognitive and/or sensorimotor behavioral phenotypes consistent with TD. Sensorimotor gating def...