19期

最新文章

• Tailoring atomic chemistry to refine reaction pathway for the most enhancement by magnetization in water oxidation AI翻译
  作者：Wu, Tianze; Ge, Jingjie; Wu, Qian; Ren, Xiao; Meng, Fanxu; Wang, Jiarui; Xi, Shibo; Wang, Xin; Elouarzaki, Kamal; Fisher, Adrian; Xu, Zhichuan J.
  作者单位：Nanyang Technological University; Hong Kong Polytechnic University; Peking University; Agency for Science Technology & Research (A*STAR); City University of Hong Kong; Nanyang Technological University; University of Cambridge; Nanyang Technological University
  摘要：Water oxidation on magnetic catalysts has generated significant interest due to the spin - polarization effect. Recent studies have revealed that the disappearance of magnetic domain wall upon magnetization is responsible for the observed oxygen evolution reaction (OER) enhancement. However, an atomic picture of the reaction pathway remains unclear, i.e., which reaction pathway benefits most from spin - polarization, the adsorbent evolution mechanism, the intermolecular mechanism (I2M), the la...
• Tailored UPRE2 variants for dynamic gene regulation in yeast AI翻译
  作者：Xiao, Chufan; Liu, Xiufang; Pan, Yuyang; Li, Yanling; Qin, Ling; Yan, Zhibo; Feng, Yunzi; Zhao, Mouming; Huang, Mingtao
  作者单位：South China University of Technology
  摘要：Genetic elements are foundational in synthetic biology serving as vital building blocks. They enable programming host cells for efficient production of valuable chemicals and recombinant proteins. The unfolded protein response (UPR) is a stress pathway in which the transcription factor Hac1 interacts with the upstream unfolded protein response element (UPRE) of the promoter to restore endoplasmic reticulum (ER) homeostasis. Here, we created a UPRE2 mutant (UPRE2m) library. Several rounds of sc...
• Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens AI翻译
  作者：Fachi, Jose L.; Di Luccia, Blanda; Gilfillan, Susan; Chang, Hao- Wei; Song, Christina; Cheng, Jiye; Cella, Marina; Vinolo, Marco Aurelio; Gordon, Jeffrey I.; Colonna, Marco
  作者单位：Washington University (WUSTL); Stanford University; Amgen; Washington University (WUSTL); Washington University (WUSTL); Universidade Estadual de Campinas
  摘要：Interleukin 22 (IL - 22) promotes intestinal barrier integrity, stimulating epithelial cells to enact defense mechanisms against enteric infections, including the production of antimicrobial peptides. IL - 22 binding protein (IL - 22BP) is a soluble decoy encoded by the Il22ra2 gene that decreases IL - 22 bioavailability, attenuating IL - 22 signaling. The impact of IL - 22BP on gut microbiota composition and functioning is poorly understood. We found that Il22ra2 -/- mice are better protected...
• Neuronal innervation regulates the secretion of neurotrophic myokines and exosomes from skeletal muscle AI翻译
  作者：Huang, Kai - Yu; Upadhyay, Gaurav; Ahn, Yujin; Sakakura, Masayoshoi; Pagan-Diaz, Gelson J.; Cho, Younghak; Weiss, Amanda C.; Huang, Chen; Mitchell, Jennifer W.; Li, Jiahui; Tan, Yanqi; Deng, Yu- Heng; Mohr, Austin Ellis-; Dou, Zhi; Zhang, Xiaotain; Kang, Sehong; Chen, Qian; Sweedler, Jonathan, V; Im, Sung Gap; Bashir, Rashid; Chung, Hee Jung; Popescu, Gabriel; Gillette, Martha U.; Gazzola, Mattia; Kong, Hyunjoon
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Chan Zuckerberg Initiative (CZI); University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Korea University; Korea Institute of Science & Technology (KIST)
  摘要：Myokines and exosomes, originating from skeletal muscle, are shown to play a significant role in maintaining brain homeostasis. While exercise has been reported to promote muscle secretion, little is known about the effects of neuronal innervation and activity on the yield and molecular composition of biologically active molecules from muscle. As neuromuscular diseases and disabilities associated with denervation impact muscle metabolism, we hypothesize that neuronal innervation and firing may...
• Development of porcine skeletal muscle extracellular matrix-derived hydrogels with improved properties and low immunogenicity AI翻译
  作者：Barajaa, Mohammed A.; Otsuka, Takayoshi; Ghosh, Debolina; Kan, Ho-Man; Laurencin, Cato T.
  作者单位：Imam Abdulrahman Bin Faisal University; University of Connecticut; University of Connecticut; University of Connecticut; University of Connecticut; University of Connecticut
  摘要：Hydrogels derived from decellularized extracellular matrices (ECM) of animal origin show immense potential for regenerative applications due to their excellent cytocompatibility and biomimetic properties. Despite these benefits, the impact of decellularization protocols on the properties and immunogenicity of these hydrogels remains relatively unexplored. In this study, porcine skeletal muscle ECM (smECM) underwent decellularization using mechanical disruption (MD) and two commonly employed de...
• Coming of age in venom research AI翻译
  作者：de la Vega, Ricardo C. Rodriguez
  作者单位：Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); AgroParisTech
• Localizing somatic symptoms associated with childhood maltreatment AI翻译
  作者：Dutcher, Ethan G.; Verosky, Sara C.; Mendes, Wendy Berry; Mayer, Stefanie E.
  作者单位：University of California System; University of California San Francisco; University System of Ohio; Oberlin College; Yale University
  摘要：Childhood maltreatment has been linked to adult somatic symptoms, although this has rarely been examined in daily life. Furthermore, the localization of somatization associated with childhood maltreatment and its subtypes is unknown. This large - scale experience sampling study used body maps to examine the relationships between childhood maltreatment, its subtypes, and the intensity and location of negative somatic sensations in daily life. Participants (N = 2,234; 33% female and 67% male) we...
• 3D intrusions transport active surface microbial assemblages to the dark ocean AI翻译
  作者：Freilich, Mara A.; Poirier, Camille; Dever, Mathieu; Alou-Font, Eva; Allen, John; Cabornero, Andrea; Sudek, Lisa; Choi, Chang Jae; Ruiz, Simon; Pascual, Ananda; Farrar, J. Thomas; Johnston, T. M. Shaun; D'Asaro, Eric A.; Worden, Alexandra Z.; Mahadevan, Amala
  作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; Brown University; Brown University; Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; Woods Hole Oceanographic Institution; University of California System; University of California Santa Cruz; Consejo Superior de Investigaciones Cientificas (CSIC); ATTITUS Educacao; University of Washington; University of Washington Seattle; Marine Biological Laboratory - Woods Hole
  摘要：Subtropical oceans contribute significantly to global primary production, but the fate of the picophytoplankton that dominate in these low - nutrient regions is poorly understood. Working in the subtropical Mediterranean, we demonstrate that subduction of water at ocean fronts generates 3D intrusions with uncharacteristically high carbon, chlorophyll, and oxygen that extend below the sunlit photic zone into the dark ocean. These contain fresh picophytoplankton assemblages that resemble the pho...
• Identification and epidemiological study of an uncultured flavivirus from ticks using viral metagenomics and pseudoinfectious viral particles AI翻译
  作者：Kobayashi, Daisuke; Inoue, Yusuke; Suzuki, Ryosuke; Matsuda, Mami; Shimoda, Hiroshi; Faizah, Astri Nur; Kaku, Yoshihiro; Ishijima, Keita; Kuroda, Yudai; Tatemoto, Kango; Mendoza, Milagros Virhuez-; Harada, Michiko; Nishino, Ayano; Inumaru, Mizue; Yonemitsu, Kenzo; Kuwata, Ryusei; Takano, Ai; Watanabe, Mamoru; Higa, Yukiko; Sawabe, Kyoko; Maeda, Ken; Isawa, Haruhiko
  作者单位：Japan Institute for Health Security (JIHS); National Institute of Infectious Diseases (NIID); Japan Institute for Health Security (JIHS); National Institute of Infectious Diseases (NIID); Japan Institute for Health Security (JIHS); National Institute of Infectious Diseases (NIID); Yamaguchi University; Japan Institute for Health Security (JIHS); National Institute of Infectious Diseases (NIID); Okayama University of Science
  摘要：During their blood - feeding process, ticks are known to transmit various viruses to vertebrates, including humans. Recent viral metagenomic analyses using nextgeneration sequencing (NGS) have revealed that blood - feeding arthropods like ticks harbor a large diversity of viruses. However, many of these viruses have not been isolated or cultured, and their basic characteristics remain unknown. This study aimed to present the identification of a difficult - to - culture virus in ticks using NGS...
• A time- resolved single- cell roadmap of the logic driving anterior neural crest diversification from neural border to migration stages AI翻译
  作者：Kotov, Aleksandr; Seal, Subham; Alkobtawi, Mansour; Kappes, Vincent; Ruiz, Sofia Medina; Arbes, Hugo; Harland, Richard M.; Peshkin, Leonid; Monsoro-Burq, Anne H.
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Paris Saclay; Universite PSL; UNICANCER; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Universite PSL; Institut Curie; University of California System; University of California Berkeley; Harvard University; Harvard Medical School; Institut Universitaire de France
  摘要：Neural crest cells exemplify cellular diversification from a multipotent progenitor population. However, the full sequence of early molecular choices orchestrating the emergence of neural crest heterogeneity from the embryonic ectoderm remains elusive. Gene - regulatory - networks (GRN) govern early development and cell specification toward definitive neural crest. Here, we combine ultradense singlecell transcriptomes with machine - learning and large - scale transcriptomic and epigenomic expe...