19期

最新文章

• Sum rule comparison of narrowband and broadband sum frequency generation spectra and comparison with theory AI翻译
  作者：Niu, Kai; Wang, Hong-fei; Marcus, Rudolph A.
  作者单位：Tianjin University of Technology & Education; California Institute of Technology; Westlake University; Westlake University
  摘要：Earlier sum frequency generation (SFG) experiments involve one infrared and one visible laser, and a measurement of the intensity of the response, yielding data on the surface sensitive properties of the sample. Recently, both the real and imaginary components of the susceptibility were measured in two different sets of experiments. In one set, a broadband infrared laser was used, permitting observations at very short times, while in another set the infrared laser was narrowband, permitting hi...
• Three's a crowd: Saccharibacteria episymbiosis modulates phage predation of host bacteria AI翻译
  作者：Lamont, Richard J.
  作者单位：University of Louisville
• Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo AI翻译
  作者：Tang, Vi T.; Xiang, Jie; Chen, Zhimin; McCormick, Joseph; Abbineni, Prabhodh S.; Chen, Xiao-Wei; Hoenerhoff, Mark; Emmer, Brian T.; Khoriaty, Rami; Lin, Jiandie D.; Ginsburg, David
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Loyola University Chicago; Peking University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Proteins carrying a signal peptide and/or a transmembrane domain enter the intracellular secretory pathway at the endoplasmic reticulum (ER) and are transported to the Golgi apparatus via COPII vesicles or tubules. SAR1 initiates COPII coat assembly by recruiting other coat proteins to the ER membrane. Mammalian genomes encode two SAR1 paralogs, SAR1A and SAR1B. While these paralogs exhibit similar to 90% amino acid sequence identity, it is unknown whether they perform distinct or overlapping ...
• Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type- specific HIV latency reactivation AI翻译
  作者：Blanco, Alexandra; Coronado, Robert A.; Arun, Neha; Ma, Kelly; Dar, Roy D.; Kieffer, Collin
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：HIV latency regulation in monocytes and macrophages can vary according to signals directing differentiation, polarization, and function. To investigate these processes, we generated an HIV latency model in THP- 1 monocytes and showed differential levels of HIV reactivation among clonal populations. Monocyte- to- macrophage differentiation of HIV- infected primary human CD14+ and THP- 1 cells induced HIV reactivation and showed that virus production increased concomitant with macrophage differe...
• Continuity of the Sangdanlin Paleocene section and rejection of a large Greater India in the Early Cretaceous AI翻译
  作者：Huang, Wentao; Garzanti, Eduardo; Moore, Theodore C.; Kapp, Paul; DeCelles, Peter G.; Niu, Shanshan
  作者单位：Chinese Academy of Sciences; Institute of Tibetan Plateau Research, CAS; University of Milano-Bicocca; University of Michigan System; University of Michigan; University of Arizona; North China Electric Power University
• An essential and highly selective protein import pathway encoded by nucleus- forming phage AI翻译
  作者：Morgan, Chase J.; Enustun, Eray; Armbruster, Emily G.; Birkholz, Erica A.; Prichard, Amy; Forman, Taylor; Aindow, Ann; Wannasrichan, Wichanan; Peters, Sela; Inlow, Koe; Shepherd, Isabelle L.; Razavilar, Alma; Chaikeeratisak, Vorrapon; Adler, Benjamin A.; Cress, Brady F.; Doudna, Jennifer A.; Pogliano, Kit; Villa, Elizabeth; Corbett, Kevin D.; Pogliano, Joe
  作者单位：University of California System; University of California San Diego; Chulalongkorn University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California San Diego; Howard Hughes Medical Institute; University of California System; University of California San Diego
  摘要：Targeting proteins to specific subcellular destinations is essential in prokaryotes, eukaryotes, and the viruses that infect them. Chimalliviridae phages encapsulate their genomes in a nucleus - like replication compartment composed of the protein chimallin (ChmA) that excludes ribosomes and decouples transcription from translation. These phages selectively partition proteins between the phage nucleus and the bacterial cytoplasm. Currently, the genes and signals that govern selective protein i...
• The impact of US-China tensions on US science: Evidence from the NIH investigations AI翻译
  作者：Jia, Ruixue; Roberts, Margaret E.; Wang, Ye; Yang, Eddie
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of North Carolina; University of North Carolina Chapel Hill
  摘要：Amid the discourse on foreign influence investigations in research, this study examines the impact of NIH-initiated investigations starting in 2018 on U.S. scientists' productivity, focusing on those collaborating with Chinese peers. Using publication data from 2010 to 2021, we analyze over 113,000 scientists and find that investigations coincide with reduced productivity for those with China collaborations compared to those with other international collaborators, especially when accounting fo...
• Engineering tertiary chirality in helical biopolymers AI翻译
  作者：Janowski, Jordan; Pham, Van A. B.; Vecchioni, Simon; Woloszyn, Karol; Lu, Brandon; Zou, Yijia; Erkalo, Betel; Perren, Lara; Rueb, Joe; Madnick, Jesse; Mao, Chengde; Saito, Masahico; Ohayon, Yoel P.; Jonoska, Natasa; Sha, Ruojie
  作者单位：New York University; State University System of Florida; University of South Florida; University of Oregon; Purdue University System; Purdue University
  摘要：Tertiary chirality describes the handedness of supramolecular assemblies and relies not only on the primary and secondary structures of the building blocks but also on topological driving forces that have been sparsely characterized. Helical biopolymers, especially DNA, have been extensively investigated as they possess intrinsic chirality that determines the optical, mechanical, and physical properties of the ensuing material. Here, we employ the DNA tensegrity triangle as a model system to l...
• Incomplete- penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration AI翻译
  作者：Lee, Soah; Roestd, Alison S. Vander; Blair, Cheavar A.; Kaoh, Kerry; Bremner, Samantha B.; Childers, Matthew C.; Pathak, Divya; Heinrich, Paul; Lee, Daniel; Chirikian, Orlando; Mohran, Saffie E.; Roberts, Brock; Smith, Jacqueline E.; Jahng, James W.; Paik, David T.; Wu, Joseph C.; Gunawardane, Ruwanthi N.; Ruppel, Kathleen M.; Mack, David L.; Pruitt, Beth L.; Regnier, Michael; Wu, Sean M.; Spudich, James A.; Bernstein, Daniel
  作者单位：Stanford University; Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Stanford University; University of Michigan System; University of Michigan; University of California System; University of California Santa Barbara; University of Kentucky; University of Washington; University of Washington Seattle; Stanford University; Stanford University
  摘要：Determining the pathogenicity of hypertrophic cardiomyopathy-associated mutations in the (3- myosin heavy chain (MYH7) can be challenging due to its variable penetrance and clinical severity. This study investigates the early pathogenic effects of the incomplete- penetrant MYH7 G256E mutation on myosin function that may trigger pathogenic adaptations and hypertrophy. We hypothesized that the G256E mutation would alter myosin biomechanical function, leading to changes in cellular functions. We ...
• Predicting resilience of migratory birds to environmental change AI翻译
  作者：Lisovski, Simeon; Hoye, Bethany J.; Conklin, Jesse R.; Battley, Phil F.; Fuller, Richard A.; Gosbell, Ken B.; Klaassen, Marcel; Lee, Chengfa Benjamin; Murray, Nicholas J.; Bauer, Silke
  作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Wollongong; University of Groningen; Massey University; University of Queensland; Deakin University; Helmholtz Association; German Aerospace Centre (DLR); University of Wurzburg; James Cook University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Swiss Ornithological Institute; University of Amsterdam; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：The pace and scale of environmental change represent major challenges to many organisms. Animals that move long distances, such as migratory birds, are especially vulnerable to change since they need chains of intact habitat along their migratory routes. Estimating the resilience of such species to environmental changes assists in targeting conservation efforts. We developed a migration modeling framework to predict past (1960s), present (2010s), and future (2060s) optimal migration strategies...