19期

最新文章

• The tRNAVal half: A strong endogenous Toll- like receptor 7 ligand with a 5′- terminal universal sequence signature AI翻译
  作者：Pawar, Kamlesh; Kawamura, Takuya; Kirino, Yohei
  作者单位：Thomas Jefferson University
  摘要：Toll - like receptors (TLRs) are crucial components of the innate immune system. Endosomal TLR7 recognizes single - stranded RNAs, yet its endogenous ssRNA ligands are not fully understood. We previously showed that extracellular (ex - ) 5 '- half molecules of tRNA HisGUG (the 5 '- tRNA HisGUG half) in extracellular vesicles (EVs) of human macrophages activate TLR7 when delivered into endosomes of recipient macrophages. Here, we fully explored immunostimulatory ex - 5 '- tRNA half molecules an...
• Reply to Lee and Elliott: Changes of bonding upon crystallization in phase change materials AI翻译
  作者：Raty, Jean Yves; Bichara, Christophe; Schoen, Carl Friedrich; Gatti, Carlo; Wuttig, Matthias
  作者单位：University of Liege; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); RWTH Aachen University; Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze Tecnologie Chimiche Giulio Natta (SCITEC-CNR); Helmholtz Association; Research Center Julich
• Engineered polymer nanoparticles as artificial chaperones facilitating the selective refolding of denatured enzymes AI翻译
  作者：Li, Yan; Yin, Deping; Lee, Sang Yup; Lv, Yongqin
  作者单位：Beijing University of Chemical Technology; Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST)
  摘要：Molecular chaperones assist in protein refolding by selectively binding to proteins in their nonnative states. Despite progress in creating artificial chaperones, these designs often have a limited range of substrates they can work with. In this paper, we present molecularly imprinted flexible polymer nanoparticles (nanoMIPs) designed as customizable biomimetic chaperones. We used model proteins such as cytochrome c, laccase, and lipase to screen polymeric monomers and identify the most effect...
• β- catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells AI翻译
  作者：Dutt, Previn; Haider, Nasir; Mouaaz, Samar; Podmore, Lauren; Stambolic, Vuk
  作者单位：University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre
  摘要：beta- catenin has influential roles affecting embryonic development, tissue homeostasis, and human diseases including cancer. Cellular beta- catenin levels are exquisitely controlled by a variety of regulatory mechanisms. In the course of exploring the functions of the Nek10 tyrosine kinase, we observed that deletion of Nek10 in lung adenocarcinoma cells resulted in dramatic stabilization of beta- catenin, suggestive of a Nek10 role in the control of beta- catenin turnover. Nek10 - deficient c...
• Arno Allan Penzias (1933-2024): A visionary explorer of the Universe AI翻译
  作者：Kellermann, K. I.
  作者单位：National Radio Astronomy Observatory (NRAO)
• Structural insights into human MHC- II association with invariant chain AI翻译
  作者：Wang, Nan; Waghray, Deepa; Caveney, Nathanael A.; Jude, Kevin M.; Garcia, K. Christopher
  作者单位：Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University
  摘要：The loading of processed peptides on to major histocompatibility complex II (MHC - II) molecules for recognition by T cells is vital to cell - mediated adaptive immunity. As part of this process, MHC - II associates with the invariant chain (Ii) during biosynthesis in the endoplasmic reticulum to prevent premature peptide loading and to serve as a scaffold for subsequent proteolytic processing into MHC - II - CLIP. Cryo-electron microscopy structures of full - length Human Leukocyte Antigen - ...
• OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition AI翻译
  作者：Nan, Yabing; Wu, Xiaowei; Luo, Qingyu; Chang, Wan; Zhao, Pengfei; Zhang, Lingqiang; Liu, Zhihua
  作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Cancer Institute & Hospital - CAMS; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard Medical School
  摘要：Ovarian cancer is an aggressive gynecological tumor characterized by a high relapse rate and chemoresistance. Ovarian cancer exhibits the cancer hallmark of elevated glycolysis, yet effective strategies targeting cancer cell metabolic reprogramming to overcome therapeutic resistance in ovarian cancer remain elusive. Here, we revealed that epigenetic silencing of Otubain 2 ( OTUB2 ) is a driving force for mitochondrial metabolic reprogramming in ovarian cancer, which promotes tumorigenesis and ...
• Healthy sleep durations appear to vary across cultures AI翻译
  作者：Ou, Christine; Lou, Nigel Mantou; Maheshka, Charul; Shi, Marc; Takemura, Kosuke; Cheung, Benjamin; Heine, Steven J.
  作者单位：University of Victoria; University of Victoria; University of British Columbia; Shiga University
  摘要：Past research finds that sleep duration is reliably linked with health yet sleep durations differ substantially between countries. We investigated whether countries with shorter sleep durations have worse health. Study 1 analyzed national sleep durations from 14 past investigations (k = 353) and found that they were not associated with national health. Study 2 collected sleep duration and health data from people from 20 different countries (N = 4,933). Average sleep durations varied substantia...
• CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV AI翻译
  作者：Immler, Roland; Nussbaumer, Katrin; Doerner, Axel; El Bounkari, Omar; Huber, Silke; Abisch, Janine; Napoli, Matteo; Schmidt, Sarah; Margraf, Andreas; Pruenster, Monika; Rohwedder, Ina; Lange-Sperandio, Baerbel; Mall, Marcus A.; de Jong, Renske; Ohnmacht, Caspar; Bernhagen, Juergen; Voehringer, David; Marth, Jamey D.; Frommhold, David; Sperandio, Markus
  作者单位：University of Munich; Ruprecht Karls University Heidelberg; University of Munich; University of Munich; University of Munich; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Munich; Munich Heart Alliance; University of Erlangen Nuremberg; Sanford Burnham Prebys Medical Discovery Institute
  摘要：Eosinophil recruitment is a pathological hallmark of many allergic and helminthic diseases. Here, we investigated chemokine receptor CCR3induced eosinophil recruitment in sialyltransferase St3gal4 -/- mice. We found a marked decrease in eosinophil extravasation into CCL11 - stimulated cremaster muscles and into the inflamed peritoneal cavity of St3gal4 -/- mice. Ex vivo flow chamber assays uncovered reduced adhesion of St3gal4 -/- compared to wild type eosinophils. Using flow cytometry, we sho...
• An HLA- E- targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis AI翻译
  作者：Paterson, Rachel L.; La Manna, Marco P.; De Souza, Victoria Arena; Walker, Andrew; Gibbs-Howe, Dawn; Kulkarni, Rakesh; Fergusson, Joannah R.; Mulakkal, Nitha Charles; Monteiro, Mauro; Bunjobpol, Wilawan; Dembek, Marcin; Martin-Urdiroz, Magdalena; Grant, Tressan; Barber, Claire; Garay-Baquero, Diana J.; Tezera, Liku Bekele; Lowne, David; Britton-Rivet, Camille; Pengelly, Robert; Chepisiuk, Natalia; Singh, Praveen K.; Woon, Amanda P.; Powlesland, Alex S.; Mccully, Michelle L.; Caccamo, Nadia; Salio, Mariolina; Badami, Giusto Davide; Dorrell, Lucy; Knox, Andrew; Robinson, Ross; Elkington, Paul; Dieli, Francesco; Lepore, Marco; Leonard, Sarah; Godinho, Luis F.
  作者单位：University of Palermo; University of Palermo; Policlinico Paolo Giaccone; University of Southampton; University of Southampton
  摘要：Peptides presented by HLA - E, a molecule with very limited polymorphism, represent attractive targets for T cell receptor (TCR) - based immunotherapies to circumvent the limitations imposed by the high polymorphism of classical HLA genes in the human population. Here, we describe a TCR - based bispecific molecule that potently and selectively binds HLA - E in complex with a peptide encoded by the inhA gene of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis in humans. We ...