24期

最新文章

• The red alga Porphyridium as a host for molecular farming: Efficient production of immunologically active hepatitis C virus glycoprotein AI翻译
  作者：Hammel, Alexander; Cucos, Lia-Maria; Caras, Iuliana; Ionescu, Irina; Tucureanu, Catalin; Tofan, Vlad; Costache, Adriana; Onu, Adrian; Hoepfner, Lara; Hippler, Michael; Neupert, Juliane; Popescu, Costin-Ioan; Stavaru, Crina; Branza-Nichita, Norica; Bock, Ralph
  作者单位：Max Planck Society; Romanian Academy; Institute of Biochemistry, Bucharest; University of Munster; Okayama University; Norwegian Institute of Bioeconomy Research
  摘要：Microalgae are promising production platforms for the cost- effective production of recombinant proteins. We have recently established that the red alga Porphyridium purpureum provides superior transgene expression properties, due to the episomal maintenance of transformation vectors as multicopy plasmids in the nucleus. Here, we have explored the potential of Porphyridium to synthesize complex pharmaceutical proteins to high levels. Testing expression constructs for a candidate subunit vaccin...
• A chemical inhibitor of IST1- CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation (vol 121, e2317680121, 2024) AI翻译
  作者：Knyazeva, Anastasia; Li, Shuang; Corkery, Dale P.; Shankar, Kasturika; Herzog, Laura K.; Zhang, Xuepei; Singh, Birendra; Niggemeyer, Georg; Grill, David; Gilthorpe, Jonathan D.; Gaetani, Massimiliano; Carlson, Lars-Anders; Waldmann, Herbert; Wu, Yao-Wen
• Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism (vol 112, pg E5308, 2015) AI翻译
  作者：Prusiner, Stanley B.; Woerman, Amanda L.; Mordes, Daniel A.; Watts, Joel C.; Rampersaud, Ryan; Berry, David B.; Patel, Smita; Oehler, Abby; Lowe, Jennifer K.; Kravitz, Stephanie N.; Geschwind, Daniel H.; Glidden, David V.; Halliday, Glenda M.; Middleton, Lefkos T.; Gentleman, Steve M.; Grinberg, Lea T.; Giles, Kurt
• Geometric phase predicts locomotion performance in undulating living systems across scales AI翻译
  作者：Rieser, Jennifer M.; Chong, Baxi; Gong, Chaohui; Astley, Henry C.; Schiebel, Perrin E.; Diaz, Kelimar; Pierce, Christopher J.; Lu, Hang; Hatton, Ross L.; Choset, Howie; Goldman, Daniel I.
  作者单位：University System of Georgia; Georgia Institute of Technology; Emory University; University System of Ohio; University of Akron; Montana State University System; Montana State University Bozeman; University System of Georgia; Georgia Institute of Technology; Oregon State University; Carnegie Mellon University
  摘要：Self-propelling organisms locomote via generation of patterns of self-deformation. Despite the diversity of body plans, internal actuation schemes and environments in limbless vertebrates and invertebrates, such organisms often use similar traveling waves of axial body bending for movement. Delineating how self-deformation parameters lead to locomotor performance (e.g. speed, energy, turning capabilities) remains challenging. We show that a geometric framework, replacing laborious calculation ...
• ADH1B, the adipocyte- enriched alcohol dehydrogenase, plays an essential, cell- autonomous role in human adipogenesis AI翻译
  作者：Gautheron, Jeremie; Elsayed, Solaf; Pistorio, Valeria; Lockhart, Sam; Zammouri, Jamila; Auclair, Martine; Koulman, Albert; Meadows, Sarah R.; Lhomme, Marie; Ponnaiah, Maharajah; Si-Bouazza, Redouane; Fabrega, Sylvie; Belkadi, Abdelaziz; Delaunay, Jean Louis; Ait-Slimane, Tounsia; Feve, Bruno; Vigouroux, Corinne; Ghaffar, Tawhida Y. Abdel; O'Rahilly, Stephen; Jeru, Isabelle
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Egyptian Knowledge Bank (EKB); Ain Shams University; University of Cambridge; Universite Paris Cite; Qatar Foundation (QF); Weill Cornell Medical College Qatar; Qatar Foundation (QF); Qatar Genome Programme (QGP); Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP
  摘要：Alcohol dehydrogenase 1B (ADH1B) is a primate - specific enzyme which, uniquely among the ADH class 1 family, is highly expressed both in adipose tissue and liver. Its expression in adipose tissue is reduced in obesity and increased by insulin stimulation. Interference with ADH1B expression has also been reported to impair adipocyte function. To better understand the role of ADH1B in adipocytes, we used CRISPR/ Cas9 to delete ADH1B in human adipose stem cells (ASC). Cells lacking ADH1B failed ...
• Innate acting memory Th1 cells modulate heterologous diseases AI翻译
  作者：Rakebrandt, Nikolas; Yassini, Nima; Kolz, Anna; Schorer, Michelle; Lambert, Katharina; Goljat, Eva; Brull, Anna Estrada; Rauld, Celine; Balazs, Zsolt; Krauthammer, Michael; Carballido, Jose M.; Peters, Anneli; Joller, Nicole
  作者单位：University of Zurich; University of Zurich; University of Munich; Novartis; University of Munich
  摘要：Through immune memory, infections have a lasting effect on the host. While memory cells enable accelerated and enhanced responses upon rechallenge with the same pathogen, their impact on susceptibility to unrelated diseases is unclear. We identify a subset of memory T helper 1 (Th1) cells termed innate acting memory T (TIA) cells that originate from a viral infection and produce IFN-gamma with innate kinetics upon heterologous challenge in vivo. Activation of memory TIA cells is induced in res...
• A call for open science in forensics AI翻译
  作者：Albright, Thomas D.; Scurich, Nicholas
  作者单位：Salk Institute; University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：The modern canon of open science consists of five schools of thought that justify unfettered access to the fruits of scientific research: i) public engagement, ii) democratic right of access, iii) efficiency of knowledge gain, iv) shared technology, and v) better assessment of impact. Here, we introduce a sixth school: due process. Due process under the law includes a right to discovery by a defendant of potentially exculpatory evidence held by the prosecution. When such evidence is scientific...
• Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model AI翻译
  作者：Chang, Zhen; Gao, Dan; Liao, Liying; Sun, Junqing; Zhang, Gen; Zhang, Xue; Wang, Feiran; Li, Chunrui; Oladejo, Babayemi Olawale; Li, Shihua; Chai, Yan; Hu, Yongfei; Lu, Xuancheng; Xiao, Haixia; Qi, Jianxun; Chen, Zhihai; Gao, Feng; Wu, Yan
  作者单位：Capital Medical University; Chinese Academy of Sciences; Institute of Microbiology, CAS; Shanxi Agricultural University; University of Macau; China Agricultural University; Chinese Center for Disease Control & Prevention; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Capital Medical University
  摘要：Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high fatality rate of up to 30% caused by SFTS virus (SFTSV). However, no specific vaccine or antiviral therapy has been approved for clinical use. To develop an effective treatment, we isolated a panel of human monoclonal antibodies (mAbs). SF5 and SF83 are two neutralizing mAbs that recognize two viral glycoproteins (Gn and Gc), respectively. We found that their epitopes are closely located, and we th...
• OGA mutant aberrantly hydrolyzes O- GlcNAc modification from PDLIM7 to modulate p53 and cytoskeleton in promoting cancer cell malignancy AI翻译
  作者：Hu, Chia - Wei; Wang, Ao; Fan, Dacheng; Worth, Matthew; Chen, Zhengwei; Huang, Junfeng; Xie, Jinshan; Macdonald, John; Li, Lingjun; Jiang, Jiaoyang
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
  摘要：O - GlcNAcase (OGA) is the only human enzyme that catalyzes the hydrolysis (deglycosylation) of O - linked beta - N - acetylglucosaminylation (O - GlcNAcylation) from numerous protein substrates. OGA has broad implications in many challenging diseases including cancer. However, its role in cell malignancy remains mostly unclear. Here, we report that a cancerderived point mutation on the OGA's noncatalytic stalk domain aberrantly modulates OGA interactome and substrate deglycosylation toward a ...
• The role of mitochondria in sex- and age- specific gene expression in a species without sex chromosomes AI翻译
  作者：Li, Ning; Flanagan, Ben A.; Edmands, Suzanne; Feldman, Marcus
  作者单位：University of Southern California
  摘要：Mitochondria perform an array of functions, many of which involve interactions with gene products encoded by the nucleus. These mitochondrial functions, particularly those involving energy production, can be expected to differ between sexes and across ages. Here, we measured mitochondrial effects on sex- and age- specific gene expression in parental and reciprocal F1 hybrids between allopatric populations of Tigriopus californicus with over 20% mitochondrial DNA divergence. Because the species...