24期

最新文章

• Geospatial joint modeling of vector and parasite serology to microstratify malaria transmission AI翻译
  作者：Kearney, Ellen A.; Amratia, Punam; Kang, Su Yun; Agius, Paul A.; Alene, Kefyalew Addis; O'Flaherty, Katherine; Oo, Win Han; Cutts, Julia C.; Htike, Win; Goncalves, Daniela Da Silva; Razook, Zahra; Barry, Alyssa E.; Drew, Damien; Thi, Aung; Aung, Kyaw Zayar; Thu, Htin Kyaw; Thein, Myat Mon; Zaw, Nyi Nyi; Htay, Wai Yan Min; Soe, Aung Paing; Beeson, James G.; Simpson, Julie A.; Gething, Peter W.; Cameron, Ewan; Fowkes, Freya J. I.
  作者单位：Burnet Institute; University of Melbourne; The Kids Research Institute Australia; University of Western Australia; Deakin University; Curtin University; University of Melbourne; Peter Doherty Institute; Deakin University; University of Melbourne; Monash University; Monash University; Monash University
  摘要：The World Health Organization identifies a strong surveillance system for malaria and its mosquito vector as an essential pillar of the malaria elimination agenda. Anopheles salivary antibodies are emerging biomarkers of exposure to mosquito bites that potentially overcome sensitivity and logistical constraints of traditional entomological surveys. Using samples collected by a village health volunteer network in 104 villages in Southeast Myanmar during routine surveillance, the present study e...
• Impulsivity is a stable, measurable, and predictive psychological trait AI翻译
  作者：Huang, Yuqi; Luan, Shenghua; Wu, Baizhou; Li, Yugang; Wu, Junhui; Chen, Wenfeng; Hertwig, Ralph; Weber, Elke
  作者单位：Chinese Academy of Sciences; Institute of Psychology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Renmin University of China; Max Planck Society
  摘要：Impulsivity is a personality construct frequently employed to explain and predict important human behaviors. Major inconsistencies in its definition and measurement, however, have led some researchers to call for an outright rejection of impulsivity as a psychological construct. We address this highly unsatisfactory state with a large - scale, preregistered study ( N = 1,676) in which each participant completed 48 measures of impulsivity derived from 10 self - report scales and 10 behavioral t...
• Genome evolution of the ancient hexaploid Platanus x acerifolia (London planetree) AI翻译
  作者：Yan, Xu; Shi, Gehui; Sun, Miao; Shan, Shengchen; Chen, Runzhou; Li, Runhui; Wu, Songlin; Zhou, Zheng; Li, Yuhan; Liu, Zhenhua; Hu, Yonghong; Liu, Zhongjian; Soltis, Pamela S.; Zhang, Jiaqi; Soltis, Douglas E.; Ning, Guogui; Bao, Manzhu
  作者单位：Huazhong Agricultural University; State University System of Florida; University of Florida; Chinese Academy of Sciences; Fujian Agriculture & Forestry University; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida
  摘要：Whole - genome duplication (WGD; i.e., polyploidy) and chromosomal rearrangement (i.e., genome shuffling) significantly influence genome structure and organization. Many polyploids show extensive genome shuffling relative to their pre - WGD ancestors. No r eference genome is currently available for Platanaceae (Proteales), one of the sister groups to the core eudicots. Moreover, Platanus x acerifolia (London planetree; Platanaceae) is a widely used street tree. Given the pivotal phylogenetic p...
• Multivariate genetic architecture reveals testosterone- driven sexual antagonism in contemporary humans AI翻译
  作者：Chakrabarty, Anasuya; Chakraborty, Saikat; Nandi, Diptarup; Basu, Analabha; Feldman, Marcus
  作者单位：Department of Biotechnology (DBT) India; National Institute of Biomedical Genomics (NIBMG); Azim Premji Foundation; Azim Premji University Bengaluru
  摘要：Sex difference (SD) is ubiquitous in humans despite shared genetic architecture (SGA) between the sexes. A univariate approach, i.e., studying SD in single traits by estimating genetic correlation, does not provide a complete biological overview, because traits are not independent and are genetically correlated. The multivariate genetic architecture between the sexes can be summarized by estimating the additive genetic (co)variance across shared traits, which, apart from the cross - trait and ...
• Structure- based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1 AI翻译
  作者：Shen, Siyuan; Wu, Chao; Lin, Guifeng; Yang, Xin; Zhou, Yangli; Zhao, Chang; Miao, Zhuang; Tian, Xiaowen; Wang, Kexin; Yang, Zhiqian; Liu, Zhiyu; Guo, Nihong; Li, Yueshan; Xia, Anjie; Zhou, Pei; Liu, Jingming; Yan, Wei; Ke, Bowen; Yang, Shengyong; Shao, Zhenhua
  作者单位：Sichuan University; Sichuan University; Sichuan University; Tianfu Jincheng Laboratory; Sichuan University
  摘要：Cannabis sativa is known for its therapeutic benefit in various diseases including pain relief by targeting cannabinoid receptors. The primary component of cannabis, A 9 - tetrahydrocannabinol (THC), and other agonists engage the orthosteric site of CB1, activating both Gi and (3- arrestin signaling pathways. The activation of diverse pathways could result in on - target side effects and cannabis addiction, which may hinder therapeutic potential. A significant challenge in pharmacology is the ...
• Nonequilibrium hyperuniform states in active turbulence AI翻译
  作者：Backofen, Rainer; Altawil, Abdelrahman Y. A.; Salvalaglio, Marco; Voigt, Axel
  作者单位：Technische Universitat Dresden; Technische Universitat Dresden; Technische Universitat Dresden
  摘要：We demonstrate that the complex spatiotemporal structure in active fluids can feature characteristics of hyperuniformity. Using a hydrodynamic model, we show that the transition from hyperuniformity to nonhyperuniformity and antihyperuniformity depends on the strength of active forcing and can be related to features of active turbulence without and with scaling characteristics of inertial turbulence. Combined with identified signatures of Levy walks and nonuniversal diffusion in these systems,...
• 52,000 years of woolly rhinoceros population dynamics reveal extinction mechanisms AI翻译
  作者：Fordham, Damien A.; Brown, Stuart C.; Canteri, Elisabetta; Austin, Jeremy J.; Lomolino, Mark, V; Haythorne, Sean; Armstrong, Edward; Bocherens, Herve; Manica, Andrea; Rey-Iglesia, Alba; Rahbek, Carsten; Nogues-Bravo, David; Lorenzen, Eline D.
  作者单位：University of Adelaide; University of Copenhagen; University of Copenhagen; University of Copenhagen; State University of New York (SUNY) System; State University of New York (SUNY) College of Environmental Science & Forestry; University of Melbourne; University of Helsinki; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Eberhard Karls University of Tubingen; University of Cambridge; Peking University; University of Southern Denmark
  摘要：The extinction of the woolly rhinoceros ( Coelodonta antiquitatis ) at the onset of the Holocene remains an enigma, with conflicting evidence regarding its cause and spatiotemporal dynamics. This partly reflects challenges in determining demographic responses of late Quaternary megafauna to climatic and anthropogenic causal drivers with available genetic and paleontological techniques. Here, we show that elucidating mechanisms of ancient extinctions can benefit from a detailed understanding of...
• Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu AI翻译
  作者：Min, Charles K.; Nwachukwu, Jerome C.; Hou, Yingwei; Russo, Robin J.; Papa, Alexandra; Min, Jian; Peng, Rouming; Kim, Sung Hoon; Ziegler, Yvonne; Rangarajan, Erumbi S.; Izard, Tina; Katzenellenbogen, Benita S.; Katzenellenbogen, John A.; Nettles, Kendall W.
  作者单位：Scripps Research Institute; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; State University System of Florida; Florida Atlantic University; Hubei University; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：The estrogen receptor -alpha (ER) is thought to function only as a homodimer but responds to a variety of environmental, metazoan, and therapeutic estrogens at subsaturating doses, supporting binding mixtures of ligands as well as dimers that are only partially occupied. Here, we present a series of flexible ER ligands that bind to receptor dimers with individual ligand poses favoring distinct receptor conformations-receptor conformational heterodimers-mimicking the binding of two different li...
• Analyzing potential shifts in life expectancy: The role of baseline mortality in addition to relative changes in death rates AI翻译
  作者：Timonin, Sergey; Cooley, Caleb C.
  作者单位：Australian National University; Washington State University
• The racial composition of road users, traffic citations, and police stops AI翻译
  作者：Xu, Wenfei; Smart, Michael; Tilahun, Nebiyou; Askari, Sajad; Dennis, Zachary; Li, Houpu; Levinson, David
  作者单位：Cornell University; Rutgers University System; Rutgers University New Brunswick; University of Illinois System; University of Illinois Chicago; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Sydney
  摘要：This paper exploits the potential of Global Positioning System datasets sourced from mobile phones to estimate the racial composition of road users, leveraging data from their respective Census block group. The racial composition data encompasses approximately 46 million trips in the Chicago metropolitan region. The research focuses on the relationship between camera tickets and racial composition of drivers vs. police stops for traffic citations and the racial composition in these locations. ...