24期

最新文章

• The origins of unpredictability in life outcome prediction tasks AI翻译
  作者：Lundberg, Ian; Brown-Weinstock, Rachel; Clampet-Lundquist, Susan; Pachman, Sarah; Nelson, Timothy J.; Yang, Vicki; Edin, Kathryn; Salganik, Matthew J.
  作者单位：Cornell University; Princeton University; Saint Joseph's University; Princeton University; Princeton University
  摘要：Why are some life outcomes difficult to predict? We investigated this question through in-depth qualitative interviews with 40 families sampled from a multidecade longitudinal study. Our sampling and interviewing process was informed by the earlier efforts of hundreds of researchers to predict life outcomes for participants in this study. The qualitative evidence we uncovered in these interviews combined with a mathematical decomposition of prediction error led us to create a conceptual framew...
• TULIP: A transformer-based unsupervised language model for interacting peptides and T cell receptors that generalizes to unseen epitopes AI翻译
  作者：Meynard-Piganeau, Barthelemy; Feinauer, Christoph; Weigt, Martin; Walczak, Aleksandra M.; Mora, Thierry
  作者单位：Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Bocconi University; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Universite PSL; Ecole Normale Superieure (ENS); Sorbonne Universite
  摘要：The accurate prediction of binding between T cell receptors (TCR) and their cognate epitopes is key to understanding the adaptive immune response and developing immunotherapies. Current methods face two significant limitations: the shortage of comprehensive high-quality data and the bias introduced by the selection of the negative training data commonly used in the supervised learning approaches. We propose a method, Transformer -based Unsupervised Language model for Interacting Peptides and T...
• Protective function and differentiation cues of brain- resident CD8+T cells during surveillance of latent Toxoplasma gondii infection AI翻译
  作者：Porte, Remi; Belloy, Marcy; Audibert, Alexis; Bassot, Emilie; Aida, Amel; Alis, Marine; Miranda-Capet, Romain; Jourdes, Aurelie; van Gisbergen, Klaas P. J. M.; Masson, Frederick; Blanchard, Nicolas
  作者单位：Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Fundacao Champalimaud
  摘要：Chronic Toxoplasma gondii infection induces brain - resident CD8+ T cells (bTr), but the protective functions and differentiation cues of these cells remain undefined. Here, we used a mouse model of latent infection by T. gondii leading to effective CD8+ T cell- mediated parasite control. Thanks to antibody depletion approaches, we found that peripheral circulating CD8+ T cells are dispensable for brain parasite control during chronic stage, indicating that CD8+ bTr are able to prevent brain p...
• Substrate geometry affects population dynamics in a bacterial biofilm (vol 121, e2315361121, 2024) AI翻译
  作者：Postek, Witold; Staskiewicz, Klaudia; Lilja, Elin; Waclaw, Bartlomiej
• ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression AI翻译
  作者：Park, Jiho; Lee, Jongeun; Hur, Yunjung; Kim, Chan- Johng; Kim, Han Bit; Um, Dahun; Kim, Da Som; Lee, June - Yong; Park, Sungjun; Park, Youngjae; Kim, Tae- Kyung; Im, Sin- Hyeog; Kim, Sung Won; Kwok, Seung- Ki; Lee, Yoontae
  作者单位：Pohang University of Science & Technology (POSTECH); Catholic University of Korea; Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System; Korea Research Institute of Chemical Technology (KRICT); Catholic University of Korea; Seoul St. Mary's Hospital; Yonsei University; Catholic University of Korea; Seoul St. Mary's Hospital
  摘要：Follicular helper T (T FH ) cells mediate germinal center reactions to generate high affinity antibodies against specific pathogens, and their excessive production is associated with the pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE). ETV5, a member of the ETS transcription factor family, promotes T FH cell differentiation in mice. In this study, we examined the role of ETV5 in the pathogenesis of lupus in mice and humans. T cell-specific deletion of Et...
• A driven Kerr oscillator with two-fold degeneracies for qubit protection AI翻译
  作者：Venkatraman, Jayameenakshi; Cortinas, Rodrigo G.; Frattini, Nicholas E.; Xiao, Xu; Devoret, Michel H.
  作者单位：Yale University; Yale University; University of California System; University of California Santa Barbara
  摘要：We present the experimental finding of multiple simultaneous two -fold degeneracies in the spectrum of a Kerr oscillator subjected to a squeezing drive. This squeezing drive resulting from a three -wave mixing process, in combination with the Kerr interaction, creates an effective static two -well potential in the phase space rotating at half the frequency of the sinusoidal drive generating the squeezing. Remarkably, these degeneracies can be turned on -and -off on demand, as well as their num...
• Different ER-plasma membrane tethers play opposing roles in autophagy of the cortical ER AI翻译
  作者：Liu, Dongmei; Yuan, Hua; Chen, Shuliang; Ferro-Novick, Susan; Novick, Peter
  作者单位：University of California System; University of California San Diego
  摘要：The endoplasmic reticulum (ER) undergoes degradation by selective macroautophagy (ER - phagy) in response to starvation or the accumulation of misfolded proteins within its lumen. In yeast, actin assembly at sites of contact between the cortical ER (cER) and endocytic pits acts to displace elements of the ER from their association with the plasma membrane (PM) so they can interact with the autophagosome assembly machinery near the vacuole. A collection of proteins tether the cER to the PM. Of ...
• Reply to Timonin and Cooley: Varied effects of counterfactuals in 42 countries underscore value of within- country counterfactual AI翻译
  作者：Abrams, Leah R.; Myrskylae, Mikko; Mehta, Neil K.
  作者单位：Tufts University; Max Planck Society; University of Helsinki; University of Texas System; University of Texas Medical Branch Galveston
• Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis AI翻译
  作者：Huang, Ke-Bin; Wang, Feng-Yang; Lu, Yuan; Yang, Liang- Mei; Long, Nian; Wang, Shan - Shan; Xie, Zhiying; Levine, Matthew; Zou, Taotao; Sessler, Jonathan L.; Liang, Hong
  作者单位：Guangxi Normal University; Sun Yat Sen University; University of Texas System; University of Texas Austin
  摘要：Developing anticancer drugs with low side effects is an ongoing challenge. Immunogenic cell death (ICD) has received extensive attention as a potential synergistic modality for cancer immunotherapy. However, only a limited set of drugs or treatment modalities can trigger an ICD response and none of them have cytotoxic selectivity. This provides an incentive to explore strategies that might provide more effective ICD inducers free of adverse side effects. Here, we report a metal- based complex ...
• The ARK2N-CK2 complex initiates transcription- coupled repair through enhancing the interaction of CSB with lesion- stalled RNAPII AI翻译
  作者：Luo, Yefei; Li, Jia; Li, Xiaoman; Lin, Haodong; Mao, Zuchao; Xu, Zhanzhan; Li, Shiwei; Nie, Chen; Zhou, Xiao Albert; Liao, Junwei; Xiong, Yundong; Xu, Xingzhi; Wang, Jiadong
  作者单位：Peking University; Shenzhen University; Shenzhen University; Peking University
  摘要：Transcription is extremely important for cellular processes but can be hindered by RNA polymerase II (RNAPII) pausing and stalling. Cockayne syndrome protein B (CSB) promotes the progression of paused RNAPII or initiates transcription - coupled nucleotide excision repair (TC - NER) to remove stalled RNAPII. However, the specific mechanism by which CSB initiates TC - NER upon damage remains unclear. In this study, we identified the indispensable role of the ARK2N-CK2 complex in the CSB - mediat...