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作者：Berlinger, Sarah A.; Kuepers, Verena; Dudenas, Peter J.; Schinski, Devin; Flagg, Lucas; Lamberty, Zachary D.; Mccloskey, Bryan D.; Winter, Martin; Frechette, Joelle
作者单位：University of California System; University of California Berkeley; University of Munster; National Institute of Standards & Technology (NIST) - USA; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：Highly concentrated aqueous electrolytes (termed water- in- salt electrolytes, WiSEs) at solid- liquid interfaces are ubiquitous in myriad applications including biological signaling, electrosynthesis, and energy storage. This interface, known as the electrical double layer (EDL), has a different structure in WiSEs than in dilute electrolytes. Here, we investigate how divalent salts [zinc bis(trifluoromethylsulfonyl)imide, Zn(TFSI)2], as well as mixtures of mono- and divalent salts [lithium bi...
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作者：Amit, Uri; Uslu, Ugur; Verginadis, Ioannis I.; Kim, Michele M.; Motlagh, Seyyedeh Azar Oliaei; Diffenderfer, Eric S.; Assenmacher, Charles-Antoine; Bicher, Sandra; Atoche, Sebastian J.; Ben-Josef, Edgar; Young, Regina M.; June, Carl H.; Koumenis, Constantinos
作者单位：University of Pennsylvania; Tel Aviv University; Sackler Faculty of Medicine; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Pancreatic ductal adenocarcinoma (PDAC) represents a challenge in oncology, with limited treatment options for advanced- stage patients. Chimeric antigen receptor T cell (CAR T) therapy targeting mesothelin (MSLN) shows promise, but challenges such as the hostile immunosuppressive tumor microenvironment (TME) hinder its efficacy. This study explores the synergistic potential of combining proton radiation therapy (RT) with MSLN- targeting CAR T therapy in a syngeneic PDAC model. Proton RT signi...
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作者：Di Dio, Cinzia; Miraglia, Laura; Peretti, Giulia; Marchetti, Antonella; Rizzolatti, Giacomo
作者单位：Catholic University of the Sacred Heart; University of Parma
摘要：In intentional behavior, the final goal of an action is crucial in determining the entire sequence of motor acts. Neurons have been described in the inferior parietal lobule of monkeys, which besides encoding a specific motor act (e.g., grasping), have their discharge modulated by the final goal of the intended action (e.g., grasping- to- eat). Many of these action- constrained neurons have mirror properties responding to the observation of the motor act they encode, provided that this is embe...
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作者：Lu, Lu; Leanza, Sophie; Dai, Jize; Hutchinson, John W.; Zhao, Ruike Renee
作者单位：Stanford University; Harvard University
摘要：Multistable structures have widespread applications in the design of deployable aerospace systems, mechanical metamaterials, flexible electronics, and multimodal soft robotics due to their capability of shape reconfiguration between multiple stable states. Recently, the snap- folding of rings, often in the form of circles or polygons, has shown the capability of inducing diverse stable configurations. The natural curvature of the rod segment (curvature in its stress- free state) plays an impor...
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作者：Mahmood, Niaz; Choi, Jung- Hyun; Wu, Pei You; Dooling, Sean W.; Watkins, Trent A.; Huang, Ziying; Lipman, Jesse; Zhao, Hanjie; Yang, Anqi; Silversmith, Jake; Inglebert, Yanis; Koumenis, Constantinos; Sharma, Vijendra; Lacaille, Jean- Claude; Sossin, Wayne S.; Khoutorsky, Arkady; Mckinney, R. Anne; Costa-Mattioli, Mauro; Sonenberg, Nahum
作者单位：McGill University; McGill University; McGill University; Baylor College of Medicine; Universite de Montreal; University of Pennsylvania; University of Windsor; McGill University; McGill University; McGill University; McGill University; Baylor College of Medicine
摘要：The integrated stress response (ISR), a pivotal protein homeostasis network, plays a critical role in the formation of long- term memory (LTM). The precise mechanism by which the ISR controls LTM is not well understood. Here, we report insights into how the ISR modulates the mnemonic process by using targeted deletion of the activating transcription factor 4 (ATF4), found that the removal of ATF4 from forebrain excitatory neurons (but not from inhibitory neurons, cholinergic neurons, or astroc...
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作者：Morino-Koga, Saori; Tsuruda, Mariko; Zhao, Xueyu; Oshiro, Shogo; Yokomizo, Tomomasa; Yamane, Mariko; Tanigawa, Shunsuke; Miike, Koichiro; Usuki, Shingo; Yasunaga, Kei - ichiro; Nishinakamura, Ryuichi; Suda, Toshio; Ogawa, Minetaro
作者单位：Kumamoto University; Kumamoto University; Tokyo Women's Medical University; Kumamoto University; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); RIKEN; Kumamoto University; Kumamoto University
摘要：in vivo during mouse embryogenesis. When cultured in vitro, cells from the embryo phenotypically defined as pre-HSC-I and pre-HSC-II have the potential to differentiate into HSCs. However, minimal factors required for HSC induction from HECs have not yet been determined. In this study, we demonstrated that stem cell factor 11.5 pre-HSC-I in a serum-free and feeder-free culture condition. In contrast, E10.5 pre-HSC-I and HECs required an endothelial cell layer in addition to SCF and TPO to diff...
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作者：Eisner, Leila; Fischer, Susanne; Juster, Robert- Paul; Hassler, Tabea
作者单位：University of Zurich; Princeton University; Universite de Montreal
摘要：Lesbian, gay, bisexual, trans, intersex, and queer (LGBTIQ+) individuals encounter persistent structural inequalities and discrimination that can lead to detrimental psychological and physiological health outcomes. Amid evolving legal landscapes, little attention has been directed toward understanding the physiological health effects of societal shifts on these communities. This study aims to explore the impact of a national marriage equality vote and associated debates on psychological and bi...
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作者：Hoy, Colin W.; de Hemptinne, Coralie; Wang, Sarah S.; Harmer, Catherine J.; Apps, Matthew A. J.; Husain, Masud; Starr, Philip A.; Little, Simon
作者单位：University of California System; University of California San Francisco; State University System of Florida; University of Florida; State University System of Florida; University of Florida; University of Oxford; University of Oxford; University of Birmingham; University of Birmingham; University of Oxford; University of California System; University of California San Francisco
摘要：Choosing whether to exert effort to obtain rewards is fundamental to human motivated behavior. However, the neural dynamics underlying the evaluation of reward and effort in humans is poorly understood. Here, we report an exploratory investigation into this with chronic intracranial recordings from the prefrontal cortex (PFC) and basal ganglia (BG; subthalamic nuclei and globus pallidus) in people with Parkinson's disease performing a decision- making task with offers that varied in levels of ...
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作者：Laurent, Julie M.; Jain, Ankit; Kan, Anton; Steinacher, Mathias; Casimiro, Nadia Enrriquez; Stavrakis, Stavros; deMello, Andrew J.; Rogers, John
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：Nature is home to a variety of microorganisms that create materials under environmentally friendly conditions. While this offers an attractive approach for sustainable manufacturing, the production of materials by native microorganisms is usually slow and synthetic biology tools to engineer faster microorganisms are only available when prior knowledge of genotype-phenotype links is available. Here, we utilize a high- throughput directed evolution platform to enhance the fitness of whole microo...
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作者：Wang, Yu
作者单位：Fudan University
