31期

最新文章

• Patagonian dust, Agulhas Current, and Antarctic ice- rafted debris contributions to the South Atlantic Ocean over the past 150,000 years AI翻译
  作者：Barkley, Anne E.; Winckler, Gisela; Recasens, Cristina; Kaplan, Michael R.; Koffman, Bess G.; Calabozo, Fernando; Middleton, Jennifer L.; Anderson, Robert F.; Cai, Yue; Bolge, Louise; Longman, Jack; Goldstein, Steven L.
  作者单位：United States Environmental Protection Agency; Columbia University; Columbia University; Colby College; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); National University of Cordoba; Cicterra; Chinese Academy of Sciences; Chinese Academy of Sciences; Carl von Ossietzky Universitat Oldenburg; Northumbria University
  摘要：Disentangling inputs of aeolian dust, ice- rafted debris (IRD), and eroded continental detritus delivered by ocean currents to marine sediments provide important insights into Earth System processes and climate. This study uses Sr-Nd-Pb isotope ratios of the continent- derived (lithogenic) fraction in deep- sea core TN057-6 from the subantarctic Southern Ocean southwest of Africa over the past 150,000 y to identify source regions and quantify their relative contributions and fluxes utilizing a...
• Early metformin treatment: An effective approach for targeting fragile X syndrome pathophysiology AI翻译
  作者：Choi, Jung-Hyun; Marsal-Garcia, Laura; Peraldi, Eve; Walters, Caleb; Huang, Ziying; Gantois, Ilse; Sonenberg, Nahum
  作者单位：McGill University
  摘要：Fragile X syndrome (FXS) is the most common genetic cause of autism spectrum disorder engendered by transcriptional silencing of the fragile X messenger ribonucleoprotein 1 ( FMR1 ) gene. Given the early onset of behavioral and molecular changes, it is imperative to know the optimal timing for therapeutic intervention. Case reports documented benefits of metformin treatment in FXS children between 2 and 14 y old. In this study, we administered metformin from birth to Fmr1-/y mice which correct...
• Double- stranded RNA induces antiviral transcriptional response through the Dicer-2/Ampk/FoxO axis in an arthropod AI翻译
  作者：Gao, Jie; Liu, Chen - Fei; Liu, Ping - Ping; Wang, Xian - Wei
  作者单位：Shandong University
  摘要：Invertebrates mainly rely on sequence- specific RNA interference (RNAi) to resist viral infections. Increasing studies show that double- stranded RNA (dsRNA) can induce sequence- independent protection and that Dicer- 2, the key RNAi player that cleaves long dsRNA into small interfering RNA (siRNA), is necessary for this protection. However, how this protection occurs remains unknown. Herein, we report that it is caused by adenosine triphosphate (ATP)- hydrolysis accompanying the dsRNA- cleava...
• USP11 promotes prostate cancer progression by up- regulating AR and c- Myc activity AI翻译
  作者：Pornour, Majid; Jeon, Hee - Young; Ryu, Hyunju; Khadka, Sudeep; Xu, Rui; Chen, Hegang; Hussain, Arif; Lam, Hung - Ming; Zhuang, Zhihao; Oo, Htoo Zarni; Gleave, Martin; Dong, Xuesen; Wang, Qianben; Barbieri, Christopher; Qi, Jianfei
  作者单位：University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University of Maryland Center for Environmental Science; Institute of Marine & Environmental Technology; University System of Maryland; University of Maryland Baltimore; US Department of Veterans Affairs; Veterans Health Administration (VHA); Baltimore VA Medical Center; University of Washington; University of Washington Seattle; University of Delaware; University of British Columbia; Duke University; Duke University; Cornell University; Weill Cornell Medicine
  摘要：Androgen receptor (AR) is a main driver for castration- resistant prostate cancer (CRPC). c-Myc is an oncogene underlying prostate tumorigenesis. Here, we find that the deubiquitinase USP11 targets both AR and c-Myc in prostate cancer (PCa). USP11 expression was up- regulated in metastatic PCa and CRPC. USP11 knockdown (KD) significantly inhibited PCa cell growth. Our RNA-seq studies revealed AR and c-Myc as the top transcription factors altered after USP11 KD. ChIP-seq analysis showed that ei...
• Tropism for ciliated cells is the dominant driver of influenza viral burst size in the human airway AI翻译
  作者：Roach, Shanley N.; Shepherd, Frances K.; Mickelson, Clayton K.; Fiege, Jessica K.; Thielen, Beth K.; Pross, Lauren M.; Sanders, Autumn E.; Mitchell, Jason S.; Robertson, Mason; Fife, Brian T.; Langlois, Ryan A.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Influenza viruses pose a significant burden on global human health. Influenza has a broad cellular tropism in the airway, but how infection of different epithelial cell types impacts replication kinetics and burden in the airways is not fully understood. Using primary human airway cultures, which recapitulate the diverse epithelial cell landscape of the human airways, we investigated the impact of cell type composition on virus tropism and replication kinetics. Cultures were highly diverse acr...
• Pink noise promotes sooner state transitions during bimanual coordination AI翻译
  作者：Brink, Kolby J.; Kim, Seung Kyeom; Sommerfeld, Joel H.; Amazeen, Polemnia G.; Stergiou, Nikolaos; Likens, Aaron D.
  作者单位：University of Nebraska System; Arizona State University; Arizona State University-Tempe; Aristotle University of Thessaloniki
  摘要：The seemingly straightforward task of tying one's shoes requires a sophisticated interplay of joints, muscles, and neural pathways, posing a formidable challenge for researchers studying the intricacies of coordination. A widely accepted framework for measuring coordinated behavior is the Haken-Kelso-Bunz (HKB) model. However, a significant limitation of this model is its lack of accounting for the diverse variability structures inherent in the coordinated systems it frequently models. Variabi...
• Dynamic spatial representation of self and others' actions in the macaque frontal cortex AI翻译
  作者：Ninomiya, Taihei; Isoda, Masaki
  作者单位：National Institutes of Natural Sciences (NINS) - Japan; National Institute for Physiological Sciences (NIPS); Graduate University for Advanced Studies - Japan
  摘要：Modulation of neuronal firing rates by the spatial locations of physical objects is a widespread phenomenon in the brain. However, little is known about how neuronal responses to the actions of biological entities are spatially tuned and whether such spatially tuned responses are affected by social contexts. These issues are of key importance for understanding the neural basis of embodied social cognition, such as imitation and perspective- taking. Here, we show that spatial representation of ...
• Resolving the 22q11.2 deletion using CTLR- Seq reveals chromosomal rearrangement mechanisms and individual variance in breakpoints AI翻译
  作者：Zhou, Bo; Purmann, Carolin; Guo, Hanmin; Shin, GiWon; Huang, Yiling; Pattni, Reenal; Meng, Qingxi; Greer, Stephanie U.; Roychowdhury, Tanmoy; Wood, Raegan N.; Ho, Marcus; zu Dohna, Heinrich; Abyzov, Alexej; Hallmayer, Joachim F.; Wong, Wing H.; Ji, Hanlee P.; Urban, Alexander E.
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Mayo Clinic; American University of Beirut; Stanford University; Washington University (WUSTL); Yale University
  摘要：We developed a generally applicable method, CRISPR/Cas9- targeted long- read sequencing (CTLR-Seq), to resolve, haplotype- specifically, the large and complex regions in the human genome that had been previously impenetrable to sequencing analysis, such as large segmental duplications (SegDups) and their associated genome rearrangements. CTLR-Seq combines in vitro Cas9- mediated cutting of the genome and pulse- field gel electrophoresis to isolate intact large (i.e., up to 2,000 kb) genomic re...
• Stochastic machine learning via sigma profiles to build a digital chemical space AI翻译
  作者：Abranches, Dinis O.; Maginn, Edward J.; Colon, Yamil J.
  作者单位：University of Notre Dame
  摘要：This work establishes a different paradigm on digital molecular spaces and their efficient navigation by exploiting sigma profiles. To do so, the remarkable capability of Gaussian processes (GPs), a type of stochastic machine learning model, to correlate and predict physicochemical properties from sigma profiles is demonstrated, outperforming state- of- the- art neural networks previously published. The amount of chemical information encoded in sigma profiles eases the learning burden of machi...
• g-factor symmetry and topology in semiconductor band states AI翻译
  作者：Sharma, Mira; Divincenzo, David P.
  作者单位：RWTH Aachen University
  摘要：The g tensor, which determines the reaction of Kramers-degenerate states to an applied magnetic field, is of increasing importance in the current design of spin qubits. It is affected by details of heterostructure composition, disorder, and electric fields, but it inherits much of its structure from the effect of the spin-orbit interaction working at the crystal-lattice level. Here, we uncover interesting symmetry and topological features of g = gL + gS for important valence and conduction ban...