31期

最新文章

• Fibrinogen inhibits sonic hedgehog signaling and impairs neonatal cerebellar development after blood-brain barrier disruption AI翻译
  作者：Weaver, Olivia; Gano, Dawn; Zhou, Yungui; Kim, Hosung; Tognatta, Reshmi; Yan, Zhaoqi; Ryu, Jae Kyu; Brandt, Caroline; Basu, Trisha; Grana, Martin; Cabriga, Belinda; Alzamora, Maria del Pilar S.; Barkovich, A. James; Akassoglou, Katerina; Petersen, Mark A.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of Southern California; University of California System; University of California San Francisco
  摘要：Cerebellar injury in preterm infants with central nervous system (CNS) hemorrhage results in lasting neurological deficits and an increased risk of autism. The impact of blood- induced pathways on cerebellar development remains largely unknown, so no specific treatments have been developed to counteract the harmful effects of blood after neurovascular damage in preterm infants. Here, we show that fibrinogen, a blood- clotting protein, plays a central role in impairing neonatal cerebellar devel...
• Shot noise-mitigated secondary electron imaging with ion count-aided microscopy AI翻译
  作者：Agarwal, Akshay; Kasaei, Leila; He, Xinglin; Kitichotkul, Ruangrawee; Hitit, Oguz Kagan; Peng, Minxu; Schultz, J. Albert; Feldman, Leonard C.; Goyal, Vivek K.
  作者单位：Boston University; Rutgers University System; Rutgers University New Brunswick
  摘要：Modern science is dependent on imaging on the nanoscale, often achieved through processes that detect secondary electrons created by a highly focused incident charged particle beam. Multiple types of measurement noise limit the ultimate trade-off between the image quality and the incident particle dose, which can preclude useful imaging of dose-sensitive samples. Existing methods to improve image quality do not fundamentally mitigate the noise sources. Furthermore, barriers to assigning a phys...
• Tiny and contentious crystal clocks in volcanic rocks could aid early warning for eruptions AI翻译
  作者：McDermott, Amy
• Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations AI翻译
  作者：Shah, Osama Shiraz; Nasrazadani, Azadeh; Foldi, Julia; Atkinson, Jennifer M.; Kleer, Celina G.; McAuliffe, Priscilla F.; Johnston, Tyler J.; Stallaert, Wayne; da Silva, Edaise M.; Selenica, Pier; Dopeso, Higinio; Pareja, Fresia; Mandelker, Diana; Weigelt, Britta; Reis-Filho, Jorge S.; Bhargava, Rohit; Lucas, Peter C.; Lee, Adrian V.; Oesterreich, Steffi
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Magee-Womens Research Institute; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Memorial Sloan Kettering Cancer Center; Mayo Clinic
  摘要：Mixed invasive ductal and lobular carcinoma (MDLC) is a rare histologic subtype of breast cancer displaying both E-cadherin positive ductal and E-cadherin negative lobular morphologies within the same tumor, posing challenges with regard to anticipated clinical management. It remains unclear whether these distinct morphologies also have distinct biology and risk of recurrence. Our spatially resolved transcriptomic, genomic, and single- cell profiling revealed clinically significant differences...
• Targeted whole- genome recovery of single viral species in a complex environmental sample AI翻译
  作者：Chen, Liyin; Chen, Anqi; Zhang, Xinge Diana; Robles, Maria Teresa Saenz; Han, Hee- Sun; Xiao, Yi; Xiao, Gao; Pipas, James M.; Weitz, David A.
  作者单位：Harvard University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Harvard University
  摘要：Characterizing unknown viruses is essential for understanding viral ecology and preparing against viral outbreaks. Recovering complete genome sequences from environmental samples remains computationally challenging using metagenomics, especially for low- abundance species with uneven coverage. We present an experimental method for reliably recovering complete viral genomes from complex environmental samples. Individual genomes are encapsulated into droplets and amplified using multiple displac...
• The structure and mechanics of the cell cortex depend on the location and adhesion state AI翻译
  作者：Flormann, D. A. D.; Kainka, L.; Montalvo, G.; Anton, C.; Rheinlaender, J.; Thalla, D.; Vesperini, D.; Pohland, M. O.; Kaub, K. H.; Schu, M.; Pezzano, F.; Ruprecht, V.; Terriac, E.; Hawkins, R. J.; Lautenschlaeger, F.
  作者单位：Saarland University; Eberhard Karls University of Tubingen; University of Gottingen; Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Pompeu Fabra University; ICREA; University of Sheffield; Saarland University
  摘要：Cells exist in different phenotypes and can transition between them. A phenotype may be characterized by many different aspects. Here, we focus on the example of whether the cell is adhered or suspended and choose particular parameters related to the structure and mechanics of the actin cortex. The cortex is essential to cell mechanics, morphology, and function, such as for adhesion, migration, and division of animal cells. To predict and control cellular functions and prevent malfunctioning, ...
• Active interface bulging in Bacillus subtilis swarms promotes self-assembly and biofilm formation AI翻译
  作者：Liu, Siyu; Li, Ye; Xu, Haoran; Kearns, Daniel B.; Wu, Yilin
  作者单位：Chinese University of Hong Kong; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Indiana University System; Indiana University Bloomington
  摘要：Microbial communities such as biofilms are commonly found at interfaces. However, it is unclear how the physical environment of interfaces may contribute to the development and behavior of surface-associated microbial communities. Combining multimode imaging, single-cell tracking, and numerical simulations, here, we found that activity-induced interface bulging promotes colony biofilm formation in Bacillus subtilis swarms presumably via segregation and enrichment of sessile cells in the bulgin...
• Overlooked significance of iodic acid in new particle formation in the continental atmosphere AI翻译
  作者：Ning, An; Shen, Jiewen; Zhao, Bin; Wang, Shuxiao; Cai, Runlong; Jiang, Jingkun; Yan, Chao; Fu, Xiao; Zhang, Yunhong; Li, Jing; Ouyang, Daiwei; Sun, Yisheng; Saiz-Lopez, Alfonso; Francisco, Joseph S.; Zhang, Xiuhui
  作者单位：Beijing Institute of Technology; Tsinghua University; Beijing University of Chemical Technology; Nanjing University; Tsinghua University; Tsinghua Shenzhen International Graduate School; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Fisica Blas Cabrera (IQF-CSIC); University of Pennsylvania; University of Pennsylvania
  摘要：New particle formation (NPF) substantially affects the global radiation balance and climate. Iodic acid (IA) is a key marine NPF driver that recently has also been detected inland. However, its impact on continental particle nucleation remains unclear. Here, we provide molecular- level evidence that IA greatly facilitates clustering of two typical land- based nucleating precursors: dimethylamine (DMA) and sulfuric acid (SA), thereby enhancing particle nucleation. Incorporating this mechanism i...
• Thermally stable high- loading single Cu sites on ZSM-5 for selective catalytic oxidation of NH3 AI翻译
  作者：Chen, Lu; Guan, Xuze; Wu, Xinbang; Asakura, Hiroyuki; Hopkinson, David G.; Allen, Christopher; Callison, June; Dyson, Paul J.; Wang, Feng Ryan
  作者单位：University of London; University College London; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Kindai University (Kinki University); Diamond Light Source; University of Oxford; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory
  摘要：Rigorous comparisons between single site- and nanoparticle (NP)- dispersed catalysts featuring the same composition, in terms of activity, selectivity, and reaction mechanism, are limited. This limitation is partly due to the tendency of single metal atoms to sinter into aggregated NPs at high loadings and elevated temperatures, driven by a decrease in metal surface free energy. Here, we have developed a unique two- step method for the synthesis of single Cu sites on ZSM-5 (termed CuS/ZSM-5) w...
• Transport coefficient approach for characterizing nonequilibrium dynamics in soft matter AI翻译
  作者：He, HongRui; Liang, Heyi; Chu, Miaoqi; Jiang, Zhang; de Pablo, Juan J.; Tirrell, Matthew, V; Narayanan, Suresh; Chen, Wei
  作者单位：United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory
  摘要：Nonequilibrium states in soft condensed matter require a systematic approach to characterize and model materials, enhancing predictability and applications. Among the tools, X-ray photon correlation spectroscopy (XPCS) provides exceptional temporal and spatial resolution to extract dynamic insight into the properties of the material. However, existing models might overlook intricate details. We introduce an approach for extracting the transport coefficient, denoted as J(t), from the XPCS studi...