35期

最新文章

• The Lorenz ratio as a guide to scattering contributions to transport in strongly correlated metals AI翻译
  作者：Sun, Fei; Mishra, Simli; Stockert, Ulrike; Daou, Ramzy; Kikugawa, Naoki; Perry, Robin S.; Hassinger, Elena; Hartnoll, Sean A.; MacKenzie, Andrew P.; Sunko, Veronika
  作者单位：Max Planck Society; Centre National de la Recherche Scientifique (CNRS); Universite de Caen Normandie; National Institute for Materials Science; University of London; University College London; University of London; University College London; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; University of Cambridge; University of St Andrews; University of California System; University of California Berkeley
  摘要：In many physical situations in which many- body assemblies exist at temperature T , a characteristic quantum- mechanical time scale of approximately & hbar;/ k B T can be identified in both theory and experiment, leading to speculation that it may be the shortest meaningful time in such circumstances. This behavior can be investigated by probing the scattering rate of electrons in a broad class of materials often referred to as strongly correlated metals. It is clear that in some cases only el...
• Conserved 5-methyluridine tRNA modification modulates ribosome translocation AI翻译
  作者：Jones, Joshua D.; Franco, Monika K.; Giles, Rachel N.; Eyler, Daniel E.; Tardu, Mehmet; Smith, Tyler J.; Snyder, Laura R.; Polikanov, Yury S.; Kennedy, Robert T.; Niederer, Rachel O.; Koutmou, Kristin S.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Michigan System; University of Michigan
  摘要：While the centrality of posttranscriptional modifications to RNA biology has long been acknowledged, the function of the vast majority of modified sites remains to be discovered. Illustrative of this, there is not yet a discrete biological role assigned for one of the most highly conserved modifications, 5- methyluridine at position 54 in tRNAs (m5U54). Here, we uncover contributions of m5U54 to both tRNA maturation and protein synthesis. Our mass spectrometry analyses demonstrate that cells l...
• Insufficient evidence to conclude that confusion cannot explain cooperative behavior AI翻译
  作者：Fosgaard, Toke R.; Wengstrom, Erik
  作者单位：Technical University of Denmark; Lund University
• Reply to Fosgaard and Wengstrom: Confusion should not be used to explain cooperative behavior in public goods game experiments AI翻译
  作者：Wang, Guangrong; Li, Jianbiao; Wang, Wenhua; Niu, Xiaofei; Wang, Yue
  作者单位：Weifang University; Shandong University; Nankai University
• Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies AI翻译
  作者：Meyer, Christian T.; Smith, Brianna N.; Wang, Jing; Teuscher, Kevin B.; Grieb, Brian C.; Howard, Gregory C.; Silver, Alexander J.; Lorey, Shelly L.; Stott, Gordon M.; Moore, William J.; Lee, Taekyu; Savona, Michael R.; Weissmiller, April M.; Liu, Qi; Quaranta, Vito; Fesik, Stephen W.; Tansey, William P.
  作者单位：University of Colorado System; University of Colorado Boulder; Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Middle Tennessee State University; Vanderbilt University; Vanderbilt University
  摘要：WD40 Repeat Domain 5 (WDR5) is a highly conserved nuclear protein that recruits MYC oncoprotein transcription factors to chromatin to stimulate ribosomal protein gene expression. WDR5 is tethered to chromatin via an arginine- binding cavity known as the WIN site. Multiple pharmacological inhibitors of the WDR5- interaction site of WDR5 (WINi) have been described, including those with picomolar affinity and oral bioavailability in mice. Thus far, however, WINi have only been shown to be effecti...
• Somatic mutations in tumor- infiltrating lymphocytes impact on antitumor immunity AI翻译
  作者：Mukohara, Fumiaki; Iwata, Kazuma; Ishino, Takamasa; Inozume, Takashi; Nagasaki, Joji; Ueda, Youki; Suzawa, Ken; Ueno, Toshihide; Ikeda, Hideki; Kawase, Katsushige; Saeki, Yuka; Kawashima, Shusuke; Yamashita, Kazuo; Kawahara, Yu; Nakamura, Yasuhiro; Tabuchi, Akiko Honobe -; Watanabe, Hiroko; Dansako, Hiromichi; Kawamura, Tatsuyoshi; Suzuki, Yutaka; Honda, Hiroaki; Mano, Hiroyuki; Toyooka, Shinichi; Kawazu, Masahito; Togashi, Yosuke
  作者单位：Okayama University; Okayama University; Chiba University; Chiba University; Chiba Cancer Center; University of Yamanashi; National Cancer Center - Japan; Chiba University; Chiba University; Saitama Medical University; University of Tokyo; Tokyo Women's Medical University
  摘要：Immune checkpoint inhibitors (ICIs) exert clinical efficacy against various types of cancers by reinvigorating exhausted CD8+T cells that can expand and directly attack cancer cells (cancer- specific T cells) among tumor- infiltrating lymphocytes (TILs). Although some reports have identified somatic mutations in TILs, their effect on antitumor immunity remains unclear. In this study, we successfully established 18 cancer- specific T cell clones, which have an exhaustion phenotype, from the TIL...
• The evolution of autonomy from two cooperative specialists in fluctuating environments AI翻译
  作者：Chen, Xiaoli; Wang, Miaoxiao; Luo, Laipeng; Liu, Xiaonan; An, Liyun; Nie, Yong; Wu, Xiao-Lei
  作者单位：Peking University; Peking University; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); Sichuan University; Peking University
  摘要：From microbes to humans, organisms perform numerous tasks for their survival, including food acquisition, migration, and reproduction. A complex biological task can be performed by either an autonomous organism or by cooperation among several specialized organisms. However, it remains unclear how autonomy and cooperation evolutionarily switch. Specifically, it remains unclear whether and how cooperative specialists can repair deleted genes through direct genetic exchange, thereby regaining met...
• Clinical decisions, patient race, and flawed data AI翻译
  作者：Mullahy, John
  作者单位：University of Wisconsin System; University of Wisconsin Madison
• Anneke Levelt Sengers: An international authority in the thermodynamics of fluids and a passionate advocate for women in science AI翻译
  作者：Anisimov, Mikhail A.; Debenedetti, Pablo G.; Greer, Sandra C.; Moldover, Michael R.
  作者单位：University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park; Princeton University; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park; National Institute of Standards & Technology (NIST) - USA
• Lipid- associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2 AI翻译
  作者：Ganguly, Souradipta; Rosenthal, Sara Brin; Ishizuka, Kei; Troutman, Ty D.; Rohm, Theresa, V; Khader, Naser; Aleman-Muench, German; Sano, Yasuyo; Archilei, Sebastiano; Soroosh, Pejman; Olefsky, Jerrold M.; Feldstein, Ariel E.; Kisseleva, Tatiana; Loomba, Rohit; Glass, Christopher K.; Brenner, David A.; Dhar, Debanjan
  作者单位：Novo Nordisk; University of California System; University of California San Diego; Sanford Burnham Prebys Medical Discovery Institute; University of California System; University of California San Diego; University of California System; University of California San Diego; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：While macrophage heterogeneity during metabolic dysfunction- associated steatohepatitis (MASH) has been described, the fate of these macrophages during MASH regression is poorly understood. Comparing macrophage heterogeneity during MASH progression vs regression, we identified specific macrophage subpopulations that are critical for MASH/fibrosis resolution. We elucidated the restorative pathways and gene signatures that define regression- associated macrophages and establish the importance of...