-
作者：Volmar, Claude-Henry; Sartor, Gregory C.; Rao, Sunil J.; Ricciardi, Natalie R.; Lambert, Guerline; Brothers, Shaun P.; Wahlestedt, Claes
-
作者：Ahmed, Rashik; Liang, Mingyang; Hudson, Rhea P.; Rangadurai, Atul K.; Huang, Shuya Kate; Forman-Kay, Julie D.; Kay, Lewis E.
作者单位：University of Toronto; University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids)
摘要：Biomolecules can be sequestered into membrane- less compartments, referred to as biomolecular condensates. Experimental and computational methods have helped define the physical- chemical properties of condensates. Less is known about how the high macromolecule concentrations in condensed phases contribute solvent interactions that can remodel the free- energy landscape of other condensate- resident proteins, altering thermally accessible conformations and, in turn, modulating function. Here, ...
-
作者：Zheng, Yujie; Zhu, Lijun; Ke, Changsheng; Li, Yu; Zhou, Zhiwen; Jiang, Mou; Wang, Fang; He, Pei; Zhou, Xin; Jiang, Zhong-Xing; Chen, Shizhen
作者单位：Chinese Academy of Sciences; Innovation Academy for Precision Measurement Science & Technology, CAS; Wuhan University; Huazhong University of Science & Technology; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS
摘要：The advent of drones has revolutionized various aspects of our lives, and in the realm of biological systems, molecular drones hold immense promise as magic bullets for major diseases. Herein, we introduce a unique class of fluorinated macromolecular amphiphiles, designed in the shape of jellyfish, serving as exemplary molecular drones for fluorine- 19 and targeted cancer therapy. Functioning akin to their mechanical counterparts, these biocompatible molecular drones autonomously assemble with...
-
作者：Eatson, Jack L.; Morgan, Scott O.; Horozov, Tommy S.; Buzza, Martin A.
作者单位：University of Hull; University of Hull
摘要：In recent years, self- assembly has emerged as a powerful tool for fabricating functional materials. Since self- assembly is fundamentally determined by the particle interactions in the system, if we can gain full control over these interactions, it would open the door for creating functional materials by design. In this paper, we exploit capillary interactions between colloidal particles at liquid interfaces to create two- dimensional (2D) materials where particle interactions and self- assem...
-
作者：Hasan, Prottoy; Berezhnaya, Elena; Rodriguez-Prados, Macarena; Weaver, David; Bekeova, Carmen; Cartes-Saavedra, Benjamin; Birch, Erin; Beyer, Andreas M.; Santos, Janine H.; Seifert, Erin L.; Elrod, John W.; Hajnoczky, Gyorgy
作者单位：Thomas Jefferson University; Medical College of Wisconsin; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University
摘要：Activating Ca2+- sensitive enzymes of oxidative metabolism while preventing calcium overload that leads to mitochondrial and cellular injury requires dynamic control of mitochondrial Ca2+ uptake. This is ensured by the mitochondrial calcium uptake (MICU)1/2 proteins that gate the pore of the mitochondrial calcium uniporter (mtCU). MICU1 is relatively sparse in the heart, and recent studies claimed the mammalian heart lacks MICU1 gating of mtCU. However, genetic models have not been tested. We ...
-
作者：Shen, Weiyu; Yao, Jie; Yang, Yue
作者单位：Peking University; Beijing Institute of Technology; Peking University
摘要：Matter entanglement is a common chaotic structure found in both quantum and classical systems. For classical turbulence, viscous vortices are like sinews in fluid flows, storing and dissipating energy and accommodating strain and stress throughout a complex vortex network. However, to explain how the statistical properties of turbulence arise from elemental vortical structures remains challenging. Here, we use the quantum vortex tangle as a skeleton to generate an instantaneous classical turbu...
-
作者：Godavarthi, Swetha K.; Li, Hui-quan; Pratelli, Marta; Spitzer, Nicholas C.
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：Autism spectrum disorders (ASD) can be caused by environmental factors. These factors act early in the development of the nervous system and induce stereotyped repetitive behaviors and diminished social interactions, among other outcomes. Little is known about how these behaviors are produced. In pregnant women, delivery of valproic acid (VPA) (to control seizure activity or stabilize mood) or immune activation by a virus increases the incidence of ASD in offspring. We found that either VPA or...
-
作者：McDermott, Amy
-
作者：Yuan, Dongqin; Zhang, Xing; Yang, Yan; Wei, Ling; Li, Hao; Zhao, Tujing; Guo, Mengge; Li, Zheng; Huang, Zhu; Wang, Min; Dai, Zongcai; Li, Peixin; Xia, Qingyou; Qian, Wenliang; Cheng, Daojun
作者单位：Southwest University - China; Southwest University - China; Southwest University - China
摘要：Insect developmental transitions are precisely coordinated by ecdysone and juvenile hormone (JH). We previously revealed that accumulated H3K27 trimethylation (H3K27me3) at the locus encoding JH signal transducer Hairy is involved in the larval- pupal transition in insects, but the underlying mechanism remains to be fully defined. Here, we show in Drosophila and Bombyx that Rpd3- mediated H3K27 deacetylation in the prothoracic gland during the last larval instar promotes ecdysone biosynthesis ...
-
作者：Guan, Xingyue; Tang, Qian-Yuan; Ren, Weitong; Chen, Mingchen; Wang, Wei; Wolynes, Peter G.; Li, Wenfei
作者单位：Nanjing University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Hong Kong Baptist University; Changping Laboratory; Rice University
摘要：Proteins perform their biological functions through motion. Although high throughput prediction of the three-dimensional static structures of proteins has proved feasible using deep-learning-based methods, predicting the conformational motions remains a challenge. Purely data-driven machine learning methods encounter difficulty for addressing such motions because available laboratory data on conformational motions are still limited. In this work, we develop a method for generating protein allo...
