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作者：Teitgen, Abigail E.; Hock, Marcus T.; Mccabe, Kimberly J.; Childers, Matthew C.; Huber, Gary A.; Marzban, Bahador; Beard, Daniel A.; McCammon, J. Andrew; Regnier, Michael; McCulloch, Andrew D.
作者单位：University of California System; University of California San Diego; University of Washington; University of Washington Seattle; University of California System; University of California San Diego; University of Michigan System; University of Michigan; University of California System; University of California San Diego
摘要：2'-deoxy-ATP (dATP) improves cardiac function by increasing the rate of crossbridge cycling and Ca2+ transient decay. However, the mechanisms of these effects and how therapeutic responses to dATP are achieved when dATP is only a small fraction of the total ATP pool remain poorly understood. Here, we used a multiscale computational modeling approach to analyze the mechanisms by which dATP improves ventricular function. We integrated atomistic simulations of prepowerstroke myosin mechanics, cel...
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作者：Wang, Juan; Wang, Jing; Zhong, Jiuchang; Liu, Hongbin; Li, Weiming; Chen, Mulei; Xu, Li; Zhang, Wenbin; Zhang, Ze; Wei, Zhizhong; Guo, Jia; Wang, Xinyu; Sui, Jianhua; Liu, Xingpeng; Zhang, Sitao; Wang, Xiaodong
作者单位：Capital Medical University; National Institute of Biological Sciences, Beijing; Tsinghua University
摘要：Atherosclerosis is a chronic inflammatory disease of the arterial wall characterized by the accumulation of cholesterol- rich lipoproteins in macrophages. How macrophages commit to proinflammatory polarization under atherosclerosis conditions is not clear. Report here that the level of a circulating protein, leucine- rich alpha- 2 glycoprotein 1 (LRG1), is elevated in the atherosclerotic tissue and serum samples from patients with coronary ization through the activation of extracellular signal...
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作者：Hu, Yizong; Tzeng, Stephany Y.; Cheng, Leonardo; Lin, Jinghan; Villabona-Rueda, Andres; Yu, Shuai; Li, Sixuan; Schneiderman, Zachary; Zhu, Yining; Ma, Jingyao; Wilson, David R.; Shannon, Sydney R.; Warren, Tiarra; Rui, Yuan; Qiu, Chenhu; Kavanagh, Erin W.; Luly, Kathryn M.; Zhang, Yicheng; Korinetz, Nicole; D'Alessio, Franco R.; Wang, Tza-Huei; Kokkoli, Efrosin; Reddy, Sashank K.; Luijten, Erik; Green, Jordan J.; Mao, Hai-Quan
作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Northwestern University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Northwestern University; Northwestern University; Northwestern University; Massachusetts Institute of Technology (MIT)
摘要：Size- dependent phagocytosis is a well- characterized phenomenon in monocytes and macrophages. However, this size effect for preferential gene delivery to these important cell targets has not been fully exploited because commonly adopted stabilization methods for electrostatically complexed nucleic acid nanoparticles, such as PEGylation and charge repulsion, typically arrest the vehicle size below 200 nm. Here, we bridge the technical gap in scalable synthesis of larger submicron gene delivery...
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作者：Mehta, Kritika; Yentsch, Henry; Lee, Jungbin; Yook, Yeeun; Lee, Kwan Young; Gao, Tianyu Terry; Tsai, Nien-Pei; Zhang, Kai
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Activity- regulated cytoskeleton- associated protein (Arc/Arg3.1) is an immediate early gene that plays a vital role in learning and memory. Arc protein has structural and functional properties similar to viral Group- specific antigen (Gag) protein and mediates the intercellular RNA transfer through virus- like capsids. However, the regulators and secretion pathway through which Arc capsids maneuver cargos are unclear. Here, we identified that phosphatidylinositol-3- phosphate (PI3P) mediates ...
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作者：Martinez, Eric; Mollica, Francis; Gibson, Edward
作者单位：University of Chicago; University of Melbourne; Massachusetts Institute of Technology (MIT)
摘要：Whereas principles of communicative efficiency and legal doctrine dictate that laws be comprehensible to the common world, empirical evidence suggests legal documents are largely incomprehensible to lawyers and laypeople alike. Here, a corpus analysis (n = 59 million words) first replicated and extended prior work revealing laws to contain strikingly higher rates of complex syntactic structures relative to six baseline genres of English. Next, two preregistered text generation experiments (n =...
