Interoceptive signals shape the earliest markers and neural pathway to awareness at the visual threshold

• 成果类型: Article
• 署名作者: Leupin, Viviana; Britz, Juliane
• 署名单位: University of Fribourg
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-15354
• DOI: 10.1073/pnas.2311953121
• 发表日期: 2024-09-10
• 关键词: respiratory sinus arrhythmia; cardiac cycle; heart-rate; connectivity; eeg; oscillations; phase; meg; consciousness; perception

摘要

respiratory cycle can modulate cortical excitability and so affect awareness. It remains debated at what stages of processing they affect awareness- related event- related potentials (ERPs) in different sensory modalities. We investigated the influence of the cardiac (systole/diastole) and the respiratory (inhalation/exhalation) phase on awareness- related ERPs. Subjects discriminated visual threshold stimuli while their electroencephalogram, electrocardiogram, and respiration were simultaneously recorded. We compared ERPs and their intracranial generators for stimuli classified correctly with and without awareness as a function of the cardiac and respiratory phase. Cyclic variations of interoceptive signals from the BRs modulated both the earliest electrophysiological markers and the trajectory of brain activity when subjects became aware of the stimuli: an early sensory component (P1) was the earliest marker of awareness for low (diastole/inhalation) and activity, indicating that BR signals interfere with the sensory processing of the visual input. Likewise, activity spread from the primary visceral cortex (posterior insula) to posterior parietal cortices during high and from associative interoceptive centers (anteearliest markers of awareness and the brain processes underlying conscious awareness.