2024

最新文章

• Quantifying a light- induced energetic change in bacteriorhodopsin by force spectroscopy AI翻译
  作者：Jacobson, David R.; Perkins, Thomas T.
  作者单位：Clemson University; National Institute of Standards & Technology (NIST) - USA; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
  摘要：Ligand- induced conformational changes are critical to the function of many membrane proteins and arise from numerous intramolecular interactions. In the photocycle of the model membrane protein bacteriorhodopsin (bR), absorption of a photon by retinal triggers a conformational cascade that results in pumping a proton across the cell membrane. While decades of spectroscopy and structural studies have probed this photocycle in intricate detail, changes in intramolecular energetics that underlie...
• Loss of activation by GABA in vertebrate delta ionotropic glutamate receptors AI翻译
  作者：Rosano, Giulio; Barzasi, Allan; Lynagh, Timothy
  作者单位：University of Bergen
  摘要：Ionotropic glutamate receptors (iGluRs) mediate excitatory signals between cells by binding neurotransmitters and conducting cations across the cell membrane. In the mammalian brain, most of these signals are mediated by two types of iGluRs: AMPA and NMDA (i.e. iGluRs sensitive to 2- amino - 3- (5- methyl- 3- oxo-1,2- oxazol- 4- yl)propanoic acid and N- methyl - D- aspartic acid, respectively). Delta - type iGluRs of mammals also form neurotransmitter- binding channels in the cell membrane, bu...
• Ultrahigh frequencies of peripherally matured LGI1-and CASPR2reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis AI翻译
  作者：Theorell, Jakob; Harrison, Ruby; Williams, Robyn; Raybould, Matthew I. J.; Zhao, Meng; Fox, Hannah; Fower, Andrew; Miller, Georgina; Wu, Zoe; Browne, Eleanor; Mgbachi, Victor; Sun, Bo; Mopuri, Rohini; Li, Ying; Waters, Patrick; Deane, Charlotte M.; Handel, Adam; Makuch, Mateusz; Irani, Sarosh R.
  作者单位：University of Oxford; Karolinska Institutet; Karolinska Institutet; Karolinska University Hospital; University of Oxford; University of Oxford; Mayo Clinic; Mayo Clinic; Mayo Clinic
  摘要：Intrathecal synthesis of central nervous system (CNS)- reactive autoantibodies is observed across patients with autoimmune encephalitis (AE), who show multiple residual neurobehavioral deficits and relapses despite immunotherapies. We leveraged two common forms of AE, mediated by leucine-rich glioma inactivated - 1 (LGI1) and contactin- associated protein - like 2 (CASPR2) antibodies, as human models to comprehensively reconstruct and profile cerebrospinal fluid (CSF) B cell receptor (BCR) cha...
• Spectrally refined unbiased Monte Carlo estimate of the Earth's global radiative cooling AI翻译
  作者：Nyffenegger-Pere, Yaniss; Armante, Raymond; Bati, Megane; Blanco, Stephane; Dufresne, Jean-Louis; El Hafi, Mouna; Eymet, Vincent; Forest, Vincent; Fournier, Richard; Gautrais, Jacques; Lebrun, Raphael; Mellado, Nicolas; Mourtaday, Nada; Paulin, Mathias
  作者单位：Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Astrofisica de Andalucia (IAA); Universite PSL; Ecole Normale Superieure (ENS); Ecole Normale Superieure de Lyon (ENS de LYON); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Institut Polytechnique de Paris; Ecole Polytechnique; Universite de Toulouse; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite Toulouse III - Paul Sabatier; Institut National Polytechnique de Toulouse; Universite Toulouse 1 Capitole; Universite de Toulouse - Jean Jaures; Centre National de la Recherche Scientifique (CNRS); IMT - Institut Mines-Telecom; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite de Toulouse; IMT Mines Albi; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS)
  摘要：The Earth's radiative cooling is a key driver of climate. Determining how it is affected by greenhouse gas concentration is a core question in climate -change sciences. Due to the complexity of radiative transfer processes, current practices to estimate this cooling require the development and use of a suite of radiative transfer models whose accuracy diminishes as we move from local, instantaneous estimates to global estimates over the whole globe and over long periods of time (decades). Here...
• CD73 contributes to the pathogenesis of fusion- negative rhabdomyosarcoma through the purinergic signaling pathway AI翻译
  作者：Hernandez, Karla Cano; Shah, Akansha M.; Lopez, Victor A.; Tagliabracci, Vincent S.; Chen, Kenian; Xu, Lin; Bassel-Duby, Rhonda; Olson, Eric N.; Liu, Ning
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children and adolescents. Fusion- negative RMS (FN- RMS) accounts for more than 80% of all RMS cases. The long- term event- free survival rate for patients with high- grade FN- RMS is below 30%, highlighting the need for improved therapeutic strategies. CD73 is a 5 ' ectonucleotidase that hydrolyzes AMP to adenosine and regulates the purinergic signaling pathway. We found that CD73 is elevated in FN- RMS tumors that expre...
• Conducting polymers take control of the field AI翻译
  作者：Mcleod, Robert R.; Malliaras, George G.
  作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Cambridge
• Refugee settlements are highly exposed to extreme weather conditions AI翻译
  作者：Fransen, Sonja; Werntges, Anja; Hunns, Alexander; Sirenko, Mikhail; Comes, Tina
  作者单位：Maastricht University; Delft University of Technology; Eindhoven University of Technology; Maastricht University
  摘要：Involuntary displacement from conflict and other causes leads to clustering of refugees and internally displaced people, often in long-term settlements. Within refugee-hosting countries, refugee settlements are frequently located in isolated and remote areas, characterized by poor-quality land and harsh climatic conditions. Yet, the exposure of refugee settlements to climatic events is underresearched. In this article, we study the exposure of the 20 largest refugee settlements worldwide to ex...
• Societal determinants of flood-induced displacement AI翻译
  作者：Vestby, Jonas; Schutte, Sebastian; Tollefsen, Andreas Foro; Buhaug, Halvard
  作者单位：Peace Research Institute Oslo (PRIO); Norwegian University of Science & Technology (NTNU)
  摘要：What explains human consequences of weather-related disaster? Here, we explore how core socioeconomic, political, and security conditions shape flood-induced displacement worldwide since 2000. In-sample regression analysis shows that extreme displacement levels are more likely in contexts marked by low national income levels, nondemocratic political systems, high local economic activity, and prevalence of armed conflict. The analysis also reveals large residual differences across continents, w...
• Substitution of Met-38 to Ile in γ- synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid AI翻译
  作者：Aubrey, Liam D.; Ninkina, Natalia; Ulamec, Sabine M.; Abramycheva, Natalia Y.; Vasili, Eftychia; Devine, Oliver M.; Wilkinson, Martin; Mackinnon, Eilish; Limorenko, Galina; Walko, Martin; Muwanga, Sarah; Amadio, Leonardo; Peters, Owen M.; Illarioshkin, Sergey N.; Outeiro, Tiago F.; Ranson, Neil A.; Brockwell, David J.; Buchman, Vladimir L.; Radford, Sheena E.
  作者单位：University of Leeds; Cardiff University; Belgorod State University; Research Center of Neurology; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); University of Leeds; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; Newcastle University - UK; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE)
  摘要：alpha-, beta-, and gamma-Synuclein are intrinsically disordered proteins implicated in physiological processes in the nervous system of vertebrates. alpha-synuclein (alpha Syn) is the amyloido-genic protein associated with Parkinson's disease and certain other neurodegenerative disorders. Intensive research has focused on the mechanisms that cause alpha Syn to form amyloid structures, identifying its NAC region as being necessary and sufficient for amyloid assembly. Recent work has shown that ...
• Magnon- mediated qubit coupling determined via dissipation measurements AI翻译
  作者：Fukami, Masaya; Marcks, Jonathan C.; Candido, Denis R.; Weiss, Leah R.; Soloway, Benjamin; Sullivan, Sean E.; Delegan, Nazar; Heremans, F. Joseph; Flatte, Michael E.; Awschalom, David D.
  作者单位：University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; University of Iowa; Tohoku University; Eindhoven University of Technology
  摘要：Controlled interaction between localized and delocalized solid -state spin systems offers a compelling platform for on -chip quantum information processing with quantum spintronics. Hybrid quantum systems (HQSs) of localized nitrogen- vacancy (NV) centers in diamond and delocalized magnon modes in ferrimagnets-systems with naturally commensurate energies-have recently attracted significant attention, especially for interconnecting isolated spin qubits at length- scales far beyond those set by ...