2024

最新文章

• Open ocean convection drives enhanced eastern pathway of the glacial Atlantic Meridional Overturning Circulation AI翻译
  作者：Gu, Sifan; Liu, Zhengyu; Ng, Hong Chin; Lynch-Stieglitz, Jean; Mcmanus, Jerry F.; Spall, Michael; Jahn, Alexandra; He, Chengfei; Li, Lingwei; Yan, Mi; Wu, Lixin
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; University System of Ohio; Ohio State University; Nanjing Normal University; University of Bristol; University System of Georgia; Georgia Institute of Technology; Columbia University; Woods Hole Oceanographic Institution; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Miami; Ocean University of China
  摘要：Abundant proxy records suggest a profound reorganization of the Atlantic Meridional Overturning Circulation (AMOC) during the Last Glacial Maximum (LGM, similar to 21,000 y ago), with the North Atlantic Deep Water (NADW) shoaling significantly relative to the present-day (PD) and forming Glacial North Atlantic Intermediate Water (GNAIW). However, almost all previous observational and modeling studies have focused on the zonal mean two-dimensional AMOC feature, while recent progress in the unde...
• Strain learning in protein-based mechanical metamaterials AI翻译
  作者：Sadaba, Naroa; Sanchez-Rexach, Eva; Waltmann, Curt; Hilburg, Shayna L.; Pozzo, Lilo D.; de la Cruz, Monica Olvera; Sardon, Haritz; Meza, Lucas R.; Nelson, Alshakim
  作者单位：University of Washington; University of Washington Seattle; University of Basque Country; POLYMAT; University of Basque Country; Northwestern University; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：Mechanical deformation of polymer networks causes molecular-level motion and bond scission that ultimately lead to material failure. Mitigating this strain-induced loss in mechanical integrity is a significant challenge, especially in the development of active and shape-memory materials. We report the additive manufacturing of mechanical metamaterials made with a protein-based polymer that undergo a unique stiffening and strengthening behavior after shape recovery cycles. We utilize a bovine s...
• Aligning the smiles of dating dyads causally increases attraction AI翻译
  作者：Sarah, Pablo Arias-; Bedoya, Daniel; Daube, Christoph; Aucouturier, Jean- Julien; Hall, Lars; Johansson, Petter
  作者单位：Lund University; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Information Sciences & Technologies (INS2I); Sorbonne Universite; Universite Marie et Louis Pasteur; Centre National de la Recherche Scientifique (CNRS)
  摘要：Social interaction research is lacking an experimental paradigm enabling researchers to make causal inferences in free social interactions. For instance, the expressive signals that causally modulate the emergence of romantic attraction during interactions remain unknown. To disentangle causality in the wealth of covarying factors that govern social interactions, we developed an open- source video- conference platform enabling researchers to covertly manipulate the social signals produced by p...
• Adaptive CVgen: Leveraging reinforcement learning for advanced sampling in protein folding and chemical reactions AI翻译
  作者：Shen, Wenhui; Wan, Kaiwei; Li, Dechang; Gao, Huajian; Shi, Xinghua
  作者单位：Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Zhejiang University; Tsinghua University
  摘要：Enhanced sampling techniques have traditionally encountered two significant challenges: identifying suitable reaction coordinates and addressing the exploration-exploitation dilemma, particularly the difficulty of escaping local energy minima. Here, we introduce Adaptive CVgen, a universal adaptive sampling framework designed to tackle these issues. Our approach utilizes a set of collective variables (CVs) to comprehensively cover the system's potential evolutionary phase space, generating div...
• Learning- dependent gating of hippocampal inputs by frontal interneurons AI翻译
  作者：Zhang, Chun-Lei; Sontag, Lucile; Gomez-Ocadiz, Ruy; Schmidt-Hieber, Christoph
  作者单位：Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Friedrich Schiller University of Jena; Sorbonne Universite; Karolinska Institutet
  摘要：The hippocampus is a brain region that is essential for the initial encoding of episodic memories. However, the consolidation of these memories is thought to occur in the neocortex, under guidance of the hippocampus, over the course of days and weeks. Communication between the hippocampus and the neocortex during hippocampal sharp wave- ripple oscillations is believed to be critical for this memory consolidation process. Yet, the synaptic and circuit basis of this communication between brain a...
• Robust resolved phylogeny of hexapods' four classes AI翻译
  作者：Azar, Dany
  作者单位：Chinese Academy of Sciences
• Intrinsically disordered region amplifies membrane remodeling to augment selective ER-phagy AI翻译
  作者：Poveda-Cuevas, Sergio Alejandro; Lohachova, Kateryna; Markusic, Borna; Dikic, Ivan; Hummer, Gerhard; Bhaskara, Ramachandra M.
  作者单位：Goethe University Frankfurt; Goethe University Frankfurt; Max Planck Society; Goethe University Frankfurt
  摘要：Intrinsically disordered regions (IDRs) play a pivotal role in organellar remodeling. They transduce signals across membranes, scaffold signaling complexes, and mediate vesicular traffic. Their functions are regulated by constraining conformational ensembles through specific intra- and intermolecular interactions, physical tethering, and posttranslational modifications. The endoplasmic reticulum (ER)-phagy receptor FAM134B/RETREG1, known for its reticulon homology domain (RHD), includes a subs...
• Pinning down a perpetrator in postsurgical eye pain AI翻译
  作者：Chang, Dennis; Caterina, Michael J.
  作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University
• Hierarchical assembly and environmental enhancement of bacterial ice nucleators AI翻译
  作者：Renzer, Galit; Ribeiro, Ingrid de Almeida; Guo, Hao - Bo; Nowoiskyd, Janine Froehlich-; Berry, Rajiv J.; Bonn, Mischa; Molinero, Valeria; Meister, Konrad
  作者单位：Max Planck Society; Utah System of Higher Education; University of Utah; United States Department of Defense; United States Air Force; US Air Force Research Laboratory; Max Planck Society; Boise State University
  摘要：Bacterial ice nucleating proteins (INPs) are exceptionally effective in promoting the kinetically hindered transition of water to ice. Their efficiency relies on the assembly of INPs into large functional aggregates, with the size of ice nucleation sites determining activity. Experimental freezing spectra have revealed two distinct, defined aggregate sizes, typically classified as class A and C ice nucleators (INs). Despite the importance of INPs and years of extensive research, the precise nu...
• Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variant AI翻译
  作者：Carmody, Patrick J.; Roushar, Francis J.; Tedman, Austin; Wang, Wei; Herwig, Madeline; Kim, Minsoo; McDonald, Eli F.; Noguera, Karen; Wong-Roushar, Jennifer; Poirier, Jon-Luc; Zelt, Nathan B.; Pockrass, Ben T.; McKee, Andrew G.; Kuntz, Charles P.; Raju, S. Vamsee; Plate, Lars; Penn, Wesley D.; Schlebach, Jonathan P.
  作者单位：Indiana University System; Indiana University Bloomington; Purdue University System; Purdue University; University of Alabama System; University of Alabama Birmingham; Vanderbilt University; Vanderbilt University; Vanderbilt University
  摘要：The cotranslational misfolding of the cystic fibrosis transmembrane conductance regulator chloride channel (CFTR) plays a central role in the molecular basis of CF. The misfolding of the most common CF variant (OF508) remodels both the translational regulation and quality control of CFTR. Nevertheless, it is unclear how the misassembly of the nascent polypeptide may directly influence the activity of the translation machinery. In this work, we identify a structural motif within the CFTR transc...