The metabolic domestication syndrome of budding yeast

• 成果类型: Article
• 署名作者: Tengoelics, Roland; Szappanos, Balazs; Muelleder, Michael; Kalapis, Dorottya; Grezal, Gabor; Sajben, Csilla; Agostini, Federica; Mokochinski, Joao Benhur; Balint, Balazs; Nagyg, Laszlo G.; Ralser, Markus; Papp, Balazs
• 署名单位: HUN-REN; HUN-REN Biological Research Center; HUN-REN; HUN-REN Biological Research Center; Institute of Biochemistry - HAS; HUN-REN; HUN-REN Biological Research Center; Szeged University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; HUN-REN; HUN-REN Biological Research Center; Institute of Biochemistry - HAS; HUN-REN; HUN-REN Biological Research Center; Thermo Fisher Scientific
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-14218
• DOI: 10.1073/pnas.2313354121
• 发表日期: 2024-03-12
• 关键词: genome sequence; flow-injection; EVOLUTION; diversity; phenotype; LESSONS; MODEL; tool

摘要

Cellular metabolism evolves through changes in the structure and quantitative of metabolic networks. Here, we explore the evolutionary dynamics of metabolic by focusing on the collection of metabolite levels, the metabolome, which captures aspects of cellular physiology. Using a phylogenetic framework, we profiled metabolites in 27 populations of nine budding yeast species, providing a graduated view of bolic variation across multiple evolutionary time scales. Metabolite levels evolve rapidly and independently of changes in the metabolic network's structure, providing complementary information to enzyme repertoire. Although metabolome variation mulates mainly gradually over time, it is profoundly affected by domestication. found pervasive signatures of convergent evolution in the metabolomes of independently domesticated clades of Saccharomyces cerevisiae. Such recurring metabolite differences between wild and domesticated populations affect a substantial part of the metabolome, including rewiring of the TCA cycle and several amino acids that influence production, likely reflecting adaptation to human niches. Overall, our work previously unrecognized diversity in central metabolism and the pervasive influence human- driven selection on metabolite levels in yeasts.