-
作者：Shen, Siyuan; Wu, Chao; Lin, Guifeng; Yang, Xin; Zhou, Yangli; Zhao, Chang; Miao, Zhuang; Tian, Xiaowen; Wang, Kexin; Yang, Zhiqian; Liu, Zhiyu; Guo, Nihong; Li, Yueshan; Xia, Anjie; Zhou, Pei; Liu, Jingming; Yan, Wei; Ke, Bowen; Yang, Shengyong; Shao, Zhenhua
作者单位：Sichuan University; Sichuan University; Sichuan University; Tianfu Jincheng Laboratory; Sichuan University
摘要：Cannabis sativa is known for its therapeutic benefit in various diseases including pain relief by targeting cannabinoid receptors. The primary component of cannabis, A 9 - tetrahydrocannabinol (THC), and other agonists engage the orthosteric site of CB1, activating both Gi and (3- arrestin signaling pathways. The activation of diverse pathways could result in on - target side effects and cannabis addiction, which may hinder therapeutic potential. A significant challenge in pharmacology is the ...
-
作者：Dokaneheifard, Sadat; Santos, Helena Gomes Dos; Valencia, Monica Guiselle; Arigela, Harikumar; Edupuganti, Raghu Ram; Shiekhattar, Ramin
作者单位：University of Miami
摘要：Repressor element - 1 silencing transcription factor (REST) is required for the formation of mature neurons. REST dysregulation underlies a key mechanism of neurodegeneration associated with neurological disorders. However, the mechanisms leading to alterations of REST - mediated silencing of key neurogenesis genes are not known. Here, we show that BRCA1 Associated ATM Activator 1 (BRAT1), a gene linked to neurodegenerative diseases, is required for the activation of REST - responsive genes du...
-
作者：Ten Oever, Sanne; Titone, Lorenzo; te Rietmolen, Noemie; Martin, Andrea E.
作者单位：Max Planck Society; Radboud University Nijmegen; Maastricht University; Max Planck Society
摘要：Neural oscillations reflect fluctuations in excitability, which biases the percept of ambiguous sensory input. Why this bias occurs is still not fully understood. We hypothesized that neural populations representing likely events are more sensitive, and thereby become active on earlier oscillatory phases, when the ensemble itself is less excitable. Perception of ambiguous input presented during less - excitable phases should therefore be biased toward frequent or predictable stimuli that have ...
-
作者：Zhen, Jiapeng; Huang, Qiushi; Shen, Kai; Dong, Hongliang; Zhang, Shihui; Lv, Kehong; Yang, Peng; Zhang, Yong; Guo, Silin; Qiu, Jing; Liu, Guanjun
作者单位：National University of Defense Technology - China; National University of Defense Technology - China; Chinese Academy of Engineering Physics; Beijing Computational Science Research Center (CSRC); Jilin University
摘要：The key of heterostructure is the combinations created by stacking various vdW materials, which can modify interlayer coupling and electronic properties, providing exciting opportunities for designer devices. However, this simple stacking does not create chemical bonds, making it difficult to fundamentally alter the electronic structure. Here, we demonstrate that interlayer interactions in heterostructures can be fundamentally controlled using hydrostatic pressure, providing a bonding method t...
-
作者：Wu, Shanshan; Hong, Yuan; Chu, Chu; Gan, Yixia; Li, Xinrui; Tao, Mengdan; Wang, Da; Hu, Hao; Zheng, Zhilong; Zhu, Qian; Han, Xiao; Zhu, Wanying; Xu, Min; Dong, Yi; Liu, Yan; Guo, Xing
作者单位：Nanjing Medical University; Nanjing Medical University; East China Normal University; Southeast University - China; Nanjing Medical University; Nantong University
摘要：that are mainly sent from the striatum to the midbrain substantial nigra (SN), which is essential for regulating motor behaviors. Dysfunction of the Str- SN circuitry may cause a series of motor disabilities that are associated with neurodegenerative disorders, such as Huntington's disease (HD). Although the etiology of HD is known as abnormally expanded CAG repeats of the huntingtin gene, treatment of HD remains tremendously challenging. One possible reason is the lack of effective HD model t...
-
作者：Park, Jugeon; Lee, Eunee; Kim, Hoon; Ohk, Jiyeon; Jung, Hosung
作者单位：Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System
摘要：Protocadherin19 (PCDH19)-related epilepsy syndrome is a rare disorder characterized by early-onset epilepsy, intellectual disability, and autistic behaviors. PCDH19 is located on the X chromosome and encodes a calcium-dependent single-pass transmembrane protein, which regulates cell-to-cell adhesion through homophilic binding. In human, 90% of heterozygous females, containing PCDH19 wild-type and mutant cells due to random X inactivation, are affected, whereas mutant males, containing only mut...
-
作者：Thibodeau, Patricia S.; Puggioni, Gavino; Strock, Jacob; Borkman, David G.; Rynearson, Tatiana A.
作者单位：University of Rhode Island; University of Rhode Island; University of New England - Maine
摘要：Long - term ecological time series provide a unique perspective on the emergent properties of ecosystems. In aquatic systems, phytoplankton form the base of the food web and their biomass, measured as the concentration of the photosynthetic pigment chlorophyll a (chl a ), is an indicator of ecosystem quality. We analyzed temporal trends in chl a from the Long - Term Plankton Time Series in Narragansett Bay, Rhode Island, USA, a temperate estuary experiencing long - term warming and changing an...
-
作者：Wendt, Kathleen A.; Nehrbass-Ahles, Christoph; Niezgoda, Kyle; Noone, David; Kalk, Michael; Menviel, Laurie; Gottschalk, Julia; Rae, James W. B.; Schmitt, Jochen; Fischer, Hubertus; Stocker, Thomas F.; Muglia, Juan; Ferreira, David; Marcott, Shaun A.; Brook, Edward; Buizert, Christo
作者单位：Oregon State University; University of Bern; University of Bern; National Physical Laboratory - UK; University of New South Wales Sydney; University of Kiel; University of St Andrews; Centro Nacional Patagonico (CENPAT); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Reading; University of Wisconsin System; University of Wisconsin Madison
摘要：The last glacial period was punctuated by cold intervals in the North Atlantic region that culminated in extensive iceberg discharge events. These cold intervals, known as Heinrich Stadials, are associated with abrupt climate shifts worldwide. Here, we present CO 2 measurements from the West Antarctic Ice Sheet Divide ice core across Heinrich Stadials 2 to 5 at decadal - scale resolution. Our results reveal multi - decadal - scale jumps in atmospheric CO 2 concentrations within each Heinrich S...
-
作者：Vogt, Randi L.; Heck, Patrick R.; Watts, Duncan J.; Chabris, Christopher F.; Meyer, Michelle N.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
-
作者：Brychta, Robert J.; Mcgehee, Suzanne; Huang, Shan; Leitner, Brooks P.; Duckworth, Courtney J.; Fletcher, Laura A.; Kim, Katherine; Cassimatis, Thomas M.; Israni, Nikita S.; Lea, Hannah J.; Lentz, Taylor N.; Pierce, Anne E.; Jiang, Alex; Lamunion, Samuel R.; Thomas, Reed J.; Ishihara, Asuka; Courville, Amber B.; Yang, Shanna B.; Reitman, Marc L.; Cypess, Aaron M.; Chen, Kong Y.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of Health (NIH) - USA
摘要：Conventionally, women are perceived to feel colder than men, but controlled comparisons are sparse. We measured the response of healthy, lean, young women and men to a range of ambient temperatures typical of the daily environment (17 to 31 degrees C). The Scholander model of thermoregulation defines the lower critical temperature as threshold of the thermoneutral zone, below which additional heat production is required to defend core body temperature. This parameter can be used to characteriz...
