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作者:Borrel-Jensen, Nikolas; Goswami, Somdatta; Engsig-Karup, Allan P.; Karniadakis, George Em; Jeong, Cheol-Ho
作者单位:Technical University of Denmark; Brown University; Technical University of Denmark; Brown University
摘要:We address the challenge of acoustic simulations in three-dimensional (3D) virtual rooms with parametric source positions, which have applications in virtual/augmented reality, game audio, and spatial computing. The wave equation can fully describe wave phenomena such as diffraction and interference. However, conventional numerical discretization methods are computationally expensive when simulating hundreds of source and receiver positions, making simulations with parametric source positions ...
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作者:Yuan, Jiaqing; Kitchener, Andrew C.; Lackey, Laurie Bingaman; Sun, Ting; Jiangzuo, Qigao; Tuohetahong, Yilamujiang; Zhao, Le; Yang, Peng; Wang, Guiqiang; Huang, Chen; Wang, Jinhong; Hou, Wenhui; Liu, Yang; Chen, Wu; Mi, Da; Murphy, William J.; Li, Gang
作者单位:Shaanxi Normal University; University of Edinburgh; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Shaanxi University of Technology; Xi'an Jiaotong University; Texas A&M University System; Texas A&M University College Station
摘要:Habitat degradation and loss of genetic diversity are common threats faced by almost all of today's wild cats. Big cats, such as tigers and lions, are of great concern and have received considerable conservation attention through policies and international actions. However, knowledge of and conservation actions for small wild cats are lagging considerably behind. The black- footed cat, Felis nigripes, one of the smallest felid species, is experiencing increasing threats with a rapid reduction ...
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作者:Gagnon, Yannic J.; Burton, Justin C.; Roth, Connie B.
作者单位:Emory University
摘要:Interfaces of glassy materials such as thin films, blends, and composites create strong unidirectional gradients to the local heterogeneous dynamics that can be used to elucidate the length scales and mechanisms associated with the dynamic heterogeneity of glasses. We focus on bilayer films of two different polymers with very different glass transition temperatures (T-g) where previous work has demonstrated a long-range (similar to 200 nm) profile in local T-g(z) is established between immisci...
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作者:Armstrong, Chelsey Geralda; Clemente-Carvalho, Rute B. G.; Turner, Nancy J.; Wickham, Sara; Trant, Andrew; Lemay, Matthew A.
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作者:Kamiyama, Yoshiaki; Katagiri, Sotaro; Li, Yangdan; Yamashita, Kota; Takase, Hinano; Umezawa, Taishi
作者单位:Tokyo University of Agriculture & Technology; Tokyo University of Agriculture & Technology
摘要:When plants are exposed to drought stress, there is a trade- off between plant growth and stress responses. Here, we identified a signaling mechanism for the initial steps of the drought- growth trade- off. Phosphoproteomic profiling revealed that Raf13, a B1 subgroup Raf-like kinase, is dephosphorylated under drought conditions. Raf13 and the related B1-Raf Raf15 are required for growth rather than the acquisition of osmotolerance. We also found that Raf13 interacts with B55- family regulator...
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作者:Tsui, Joseph L. -H.; Zhang, Mengyan; Sambaturu, Prathyush; Busch-Moreno, Simon; Suchard, Marc A.; Pybus, Oliver G.; Flaxman, Seth; Semenova, Elizaveta; Kraemer, Moritz U. G.
作者单位:University of Oxford; University of Oxford; University of Oxford; University of California System; University of California Los Angeles; University of London; University of London Royal Veterinary College; Imperial College London
摘要:Tracking the spread of emerging pathogens is critical to the design of timely and effective public health responses. Policymakers face the challenge of allocating finite resources for testing and surveillance across locations, with the goal of maximizing the information obtained about the underlying trends in prevalence and incidence. We model this decision- making process as an iterative node classification problem on an undirected and unweighted graph, in which nodes represent locations and ...
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作者:Pillay, Rajeev; Watson, James E. M.; Hansen, Andrew J.; Burns, Patrick; Virnig, Anne Lucy Stilger; Supples, Christina; Armenteras, Dolors; Gonzalez-del-Pliegoh, Pamela; Aragon-Osejo, Jose; Jantz, Patrick A.; Ervin, Jamison; Goetz, Scott J.; Venter, Oscar
作者单位:University of Northern British Columbia; University of Queensland; University of Queensland; Montana State University System; Montana State University Bozeman; Northern Arizona University; Universidad Nacional de Colombia; University of Evora
摘要:Structurally intact native forests free from major human pressures are vitally important habitats for the persistence of forest biodiversity. However, the extent of such high- integrity forest habitats remaining for biodiversity is unknown. Here, we quantify the amount of high- integrity tropical rainforests, as a fraction of total forest cover, within the geographic ranges of 16,396 species of terrestrial vertebrates worldwide. We found up to 90% of the humid tropical ranges of forest- depend...
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作者:Hsieh, Annie L.; Ganesh, Sanika; Kula, Tomasz; Irshad, Madiha; Ferenczi, Emily A.; Wang, Wengang; Chen, Yi - Ching; Hu, Song - Hua; Li, Zongyu; Joshi, Shakchhi; Haigis, Marcia C.; Sabatini, Bernardo L.
作者单位:Howard Hughes Medical Institute; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School
摘要:Gliomas are the most common malignant primary brain tumor and are often associated with severe neurological deficits and mortality. Unlike many cancers, gliomas rarely metastasize outside the brain, indicating a possible dependency on unique features of brain microenvironment. Synapses between neurons and glioma cells exist, suggesting that glioma cells rely on neuronal inputs and synaptic signaling for proliferation. Yet, the locations and properties of neurons that innervate gliomas have rem...
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作者:Morin, Chloe; Baudin-Baillieu, Agnes; Van Long, Flora Nguyen; Isaac, Caroline; Bidou, Laure; Arbes, Hugo; Francois, Pauline; Pommier, Roxane M.; Adrait, Annie; Saku, Akari; Gran, Stephanie; Machkouri, Camelia; Vanbelle, Christophe; Morichon, Romain; Boissan, Mathieu; Catez, Frederic; Ferrari, Anthony; Morel, Anne-Pierre; Coute, Yohann; Chat, Sophie; Giudice, Emmanuel; Gillet, Reynald; Puisieux, Alain; Moyret-balle, Caroline; Diaz, Jean- Jacques; Namy, Olivier; Marcel, Virginie
作者单位:Centre National de la Recherche Scientifique (CNRS); UNICANCER; Centre Leon Berard; Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Claude Bernard Lyon 1; UNICANCER; Centre Leon Berard; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CEA; UNICANCER; Centre Leon Berard; Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Hopital Universitaire Charles-Foix - APHP; UNICANCER; Centre Leon Berard; Universite de Rennes; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); UNICANCER; Universite PSL; Institut Curie; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC)
摘要:Epithelial-mesenchymal transition (EMT) involves profound changes in cell morphology, driven by transcriptional and epigenetic reprogramming. However, evidence suggests that translation and ribosome composition also play key roles in establishing pathophysiological phenotypes. Using genome-wide analyses, we reported significant rearrangement of the translational landscape and machinery during EMT. Specifically, a cell line overexpressing the EMT transcription factor ZEB1 displayed alterations ...
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作者:Peng, Kang; Jiang, Chenxiao; Zhang, Zirui; Zhang, Chao; Wang, Jing; Song, Wanjie; Ma, Yunxin; Tang, Gonggen; Zuo, Peipei; Yang, Zhengjin; Xu, Tongwen
作者单位:Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要:Aqueous organic redox flow batteries (AORFBs), which exploit the reversible redox reactions of water- soluble organic electrolytes to store electricity, have emerged as a promising electrochemical energy storage technology. Organic electrolytes possess fast electron- transfer rates that are two or three orders of magnitude faster than those of their inorganic or organometallic counterparts; therefore, their performance at the electrode is limited by mass transport. Direct adoption of conventio...