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作者：Alnouri, Mohamad Wessam; Roquid, Kenneth Anthony; Bonnavion, Remy; Cho, Haaglim; Heering, Jan; Kwon, Jeonghyeon; Jaeger, Yannick; Wang, ShengPeng; Guenther, Stefan; Wettschureck, Nina; Geisslingerb, Gerd; Gurke, Robert; Mueller, Christa E.; Proschak, Ewgenij; Offermanns, Stefan
作者单位：Max Planck Society; Xi'an Jiaotong University; Max Planck Society; Goethe University Frankfurt; German Centre for Cardiovascular Research; Goethe University Frankfurt; University of Bonn; University of Bonn; Goethe University Frankfurt
摘要：Inflammation is a protective response to pathogens and injury. To be effective it needs to be resolved by endogenous mechanisms in order to avoid prolonged and excessive inflammation, which can become chronic. Specialized pro- resolving mediators (SPMs) are a group of lipids derived from omega- 3 fatty acids, which can induce the resolution of inflammation. How SPMs exert their anti- inflammatory and pro- resolving effects is, however, not clear. Here, we show that SPMs such as protectins, mar...
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作者：Bie, Juntao; Li, Yutong; Song, Chen; Weng, Qiaoyou; Zhao, Long; Su, Li; Zhao, Zhongwei; Ye, Yingjiang; Shen, Zhanlong; Ji, Jiansong; Luo, Jianyuan
作者单位：Peking University; Peking University; Wenzhou Medical University; Peking University; Peking University; Peking University
摘要：Chemotherapy resistance remains a significant obstacle that limits the long- term efficacy of cancer therapy, necessitating further investigations into the underlying mechanisms. Here, we find that DNA fragments induced by chemotherapeutic agents trigger the Mechanically, the lysosome- localized protein LAMTOR1 is up- regulated, and the interaction between LAMTOR1 and cGAS is enhanced upon exposure to DNA fragments, boosting the accumulation and digestion of cGAS in lysosomes through the recep...
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作者：Kusuma, Subhan Hadi; Kakizuka, Taishi; Hattori, Mitsuru; Nagai, Takeharu
作者单位：University of Osaka; University of Osaka; University of Osaka; Hokkaido University
摘要：Bioluminescence imaging has become a valuable tool in biological research, offering several advantages over fluorescence-based techniques, including the absence of phototoxicity and photobleaching, along with a higher signal-to-noise ratio. Common bioluminescence imaging methods often require the addition of an external chemical substrate (luciferin), which can result in a decrease in luminescence intensity over time and limit prolonged observations. Since the bacterial bioluminescence system ...
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作者：Vaccario, Giacomo; Xu, Shuqi; Mariani, Manuel S.; Medo, Matus
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; University of Bern; University Hospital of Bern; University of Bern; University Hospital of Bern
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作者：Heatwole, Scott E.
作者单位：National Aeronautics & Space Administration (NASA)
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作者：Cho, Stella E.; Li, Wei; Beard, Andrew M.; Jackson, Jonathan A.; Kiernan, Risa; Hoshino, Kazunori; Martin, Adam C.; Sun, Jianjun
作者单位：University of Connecticut; Massachusetts Institute of Technology (MIT); Harvard University; University of Connecticut; University of Connecticut
摘要：Ovulation is critical for sexual reproduction and consists of the process of liberating fertilizable oocytes from their somatic follicle capsules, also known as follicle rupture. The mechanical force for oocyte expulsion is largely unknown in many species. Our previous work demonstrated that Drosophila ovulation, as in mammals, requires the proteolytic degradation of the posterior follicle wall and follicle rupture to release the mature oocyte from a layer of somatic follicle cells. Here, we i...
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作者：Epper, Thomas F.; Fehr, Ernst; Kreiner, Claus Thustrup; Leth-Petersen, Soren; Olufsen, Isabel Skak; Skov, Peer Ebbesen
作者单位：Universite de Lille; IESEG School of Management; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); University of Copenhagen; University of Zurich; Auckland University of Technology
摘要：Rising inequality has brought redistribution back on the political agenda. In theory, inequality aversion drives people's support for redistribution. People can dislike both advantageous inequality (comparison relative to those worse off) and disadvantageous inequality (comparison relative to those better off). Existing experimental evidence reveals substantial variation across people in these preferences. However, evidence is scarce on the broader role of these two distinct forms of inequalit...
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作者：Goldstein, Joseph L.
作者单位：University of Texas System; University of Texas Southwestern Medical Center
摘要：The Dutch painter Piet Mondrian, famous for his geometric grid paintings, was an ardent jazz fan. In the late stage of his career, he became intrigued with boogie- woogie music, which inspired him to paint his masterpiece Broadway Boogie Woogie. While boogie- woogie and science operate in different domains, both share the characteristics of experimentation, improvisation, and pushing boundaries-whether it is creating new piano rhythms and melodies or creating new ways to discover innovative so...
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作者：Yan, Zhiyuan; Handoko, Albertus Denny; Wu, Weikang; Yang, Chuchu; Wang, Hao; Yilmaz, Meltem; Zhang, Zhiyong; Cheng, Libo; Cheng, Xinbin; Ho, Ghim Wei; Feng, Bin; Shibata, Naoya; Zhao, Rong; Yang, Joel K. W.; Chong, Chong Tow; Ikuhara, Yuichi; Qiu, Cheng - Wei
作者单位：National University of Singapore; Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Materials Research & Engineering (IMRE); Shandong University; University of Tokyo; Singapore University of Technology & Design; University of London; University College London; Tongji University; Tsinghua University; National University of Singapore
摘要：Metamaterial has been captivated a popular notion, offering photonic functionalities beyond the capabilities of natural materials. Its desirable functionality primarily relies on well- controlled conditions such as structural resonance, dispersion, geometry, filling fraction, external actuation, etc. However, its fundamental building blocks-meta- atoms-still rely on naturally occurring substances. Here, we propose and validate the concept of gradient and reversible atomic- engineered metamater...
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作者：Hur, Jihyun K.; Heffner, Joseph; Feng, Gloria W.; Joormann, Jutta; Rutledge, Robb B.
作者单位：Yale University; Yale University; Yale University; University of London; University College London
摘要：The prevalence of depression is a major societal health concern, and there is an ongoing need to develop tools that predict who will become depressed. Past research suggests that depression changes the language we use, but it is unclear whether language is predictive of worsening symptoms. Here, we test whether the sentiment of brief written linguistic responses predicts changes in depression. Across two studies (N = 467), participants provided responses to neutral open-ended questions, narrat...
