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作者:Mastrocinque, Francesco; Bullard, George; Alatis, James A.; Albro, Joseph A.; Nayak, Animesh; Williams, Nicholas X.; Kumbhar, Amar; Meikle, Hope; Widel, Zachary X. W.; Bai, Yusong; Harvey, Alexis K.; Atkin, Joanna M.; Waldeck, David H.; Franklin, Aaron D.; Therien, Michael J.; Rossky, Peter J.
作者单位:Duke University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Duke University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
摘要:Covalent bonding interactions determine the energy-momentum (E-k) dispersion (band structure) of solid - state materials. Here, we show that noncovalent interactions can modulate the E-k dispersion near the Fermi level of a low- dimensional nanoscale conductor. We demonstrate that low energy band gaps may be opened in metallic carbon nanotubes through polymer wrapping of the nanotube surface at fixed helical periodicity. Electronic spectral, chiro- optic, potentiometric, electronic device, and...
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作者:Duffy, Grant A.; Montiel, Fabien; Purich, Ariaan; Fraser, Ceridwen I.
作者单位:University of Otago; University of Otago; Monash University; Monash University
摘要:Polynyas, areas of open water embedded within sea ice, are a key component of ocean- atmosphere interactions that act as hotspots of sea - ice production, bottom - water formation, and primary productivity. The specific drivers of polynya dynamics remain, however, elusive and coupled climate models struggle to replicate Antarctic polynya activity. Here, we leverage a 44- y time series of Antarctic sea ice to elucidate long - term trends. We identify Antarctic - wide linear increases and a hith...
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作者:Porat, Amir; Tekinalp, Arman; Bhosale, Yashraj; Gazzola, Mattia; Meroz, Yasmine
作者单位:Tel Aviv University; Tel Aviv University; University of Illinois System; University of Illinois Urbana-Champaign; Tel Aviv University
摘要:By masterfully balancing directed growth and passive mechanics, plant roots are remarkably capable of navigating complex heterogeneous environments to find resources. Here, we present a theoretical and numerical framework which allows us to interrogate and simulate the mechanical impact of solid interfaces on the growth pattern of plant organs. We focus on the well-known waving, coiling, and skewing patterns exhibited by roots of Arabidopsis thaliana when grown on inclined surfaces, serving as...
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作者:Li, Bo; Wang, Xiao-Qian; Li, Qin-Yao; Xu, Da; Li, Jing; Hou, Wen-Tao; Chen, Yuxing; Jiang, Yong-Liang; Zhou, Cong-Zhao
作者单位:Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要:Coordinated carbon and nitrogen metabolism is crucial for bacteria living in the fluctuating environments. Intracellular carbon and nitrogen homeostasis is maintained by a sophisticated network, in which the widespread signaling protein PII acts as a major regulatory hub. In cyanobacteria, PII was proposed to regulate the nitrate uptake by an ABC (ATP- binding cassette)type nitrate transporter NrtABCD, in which the nucleotide- binding domain of NrtC is fused with a C- terminal regulatory domai...
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作者:Kim, Ji-Young; McGlothin, Connor; Cha, Minjeong; Pfaffenberger, Zechariah J.; Emre, Emine Sumeyra Turali; Choi, Wonjin; Kim, Sanghoon; Biteen, Julie S.; Kotov, Nicholas A.
作者单位:University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Rensselaer Polytechnic Institute; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要:Chiral plasmonic surfaces with 3D forests from nanohelicoids should provide strong optical rotation due to alignment of helical axis with propagation vector of photons. However, such three- dimensional nanostructures also demand multi - step nanofabrication, which is incompatible with many substrates. Large - scale photonic patterns on polymeric and flexible substrates remain unattainable. Here, we demonstrate the substrate- tolerant direct - write printing and patterning of silver nanohelicoi...
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作者:Heckmeier, Philipp J.; Ruf, Jeannette; Rochereau, Charlotte; Hamm, Peter
作者单位:University of Zurich; Columbia University
摘要:Protein dynamics form a critical bridge between protein structure and function, yet the impact of evolution on ultrafast processes inside proteins remains enigmatic. This study delves deep into nanosecond -scale protein dynamics of a structurally and functionally conserved protein across species separated by almost a billion years, investigating ten homologs in complex with their ligand. By inducing a photo -triggered destabilization of the ligand inside the binding pocket, we resolved distinc...
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作者:Moromizato, Rena; Fukuda, Kodai; Suzuki, Shigekatsu; Motomura, Taizo; Nagasato, Chikako; Hirakawa, Yoshihisa
作者单位:University of Tsukuba; University of Tsukuba; National Institute for Environmental Studies - Japan; Hokkaido University; University of Tsukuba
摘要:Pyrenoids are microcompartments that are universally found in the photosynthetic plastids of various eukaryotic algae. They contain ribulose-1,5- bisphosphate carboxylase/oxygenase (Rubisco) and play a pivotal role in facilitating CO2 assimilation via CO2- concentrating mechanisms (CCMs). Recent investigations involving model algae have revealed that pyrenoid- associated proteins participate in pyrenoid biogenesis and CCMs. However, these organisms represent only a small part of algal lineages...
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作者:Saito, Yuhki; Yang, Yanhong; Saito, Misa; Park, Christopher Y.; Funato, Kosuke; Tabar, Viviane; Darnell, Robert B.
作者单位:Howard Hughes Medical Institute; Rockefeller University; Rockefeller University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Simons Foundation; Flatiron Institute; University System of Georgia; University of Georgia
摘要:NOVA1 is a neuronal RNA- binding protein identified as the target antigen of a rare autoimmune disorder associated with cancer and neurological symptoms, termed paraneoplastic opsoclonus- myoclonus ataxia. Despite the strong association between NOVA1 and cancer, it has been unclear how NOVA1 function might contribute to cancer biology. In this study, we find that NOVA1 acts as an oncogenic factor in a GBM (glioblastoma multiforme) cell line established from a patient. Interestingly, NOVA1 and ...
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作者:Liang, Zhiyan; Yan, Qingyun; Ou, Huase; Li, Dawei; Zhang, Yayun; Zhang, Jinlong; Zeng, Lixi; Xing, Mingyang
作者单位:East China University of Science & Technology; East China University of Science & Technology; Jinan University; Nanjing University of Information Science & Technology; East China University of Science & Technology
摘要:Effectively managing sewage sludge from Fenton reactions in an eco-friendly way is vital for Fenton technology's viability in pollution treatment. This study focuses on sewage sludge across various treatment stages, including generation, concentration, dehydration, and landfill, and employs chemical composite MoS2 to facilitate green resource utilization of all types of sludge. MoS2, with exposed Mo4+ and low-coordination sulfur, enhances iron cycling and creates an acidic microenvironment on ...
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作者:Sun, Wenxiang; Hughes, Erik P.; Kim, Heejoo; Perovanovic, Jelena; Charley, Krystal R.; Perkins, Bryant; Du, Junhong; Ibarra, Andrea; Syage, Amber R.; Hale, J. Scott; Williams, Matthew A.; Tantin, Dean
作者单位:Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Huntsman Cancer Institute
摘要:The molecular mechanisms leading to the establishment of immunological memory are inadequately understood, limiting the development of effective vaccines and durable antitumor immune therapies. Here, we show that ectopic OCA- B expression is sufficient to improve antiviral memory recall responses, while having minimal effects on primary effector responses. At peak viral response, short- lived effector T cell populations are expanded but show increased Gadd45b and Socs2 expression, while memory...