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作者：Gittleman, John L.
作者单位：University System of Georgia; University of Georgia; Duke University
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作者：Matsushita, Yumi; Yoshida, Kaede; Yoshiya, Miyuki; Shimizu, Takahiro; Tsukamoto, Satoshi; Kudo, Nobuki; Takeuchi, Yuichi; Higuchi, Makoto; Shimojo, Masafumi
作者单位：National Institutes for Quantum Science & Technology; Hokkaido University; National Institutes for Quantum Science & Technology; Hokkaido University; Kindai University (Kinki University)
摘要：Ultrasound neuromodulation has become an innovative technology that enables noninvasive intervention in mammalian brain circuits with high spatiotemporal precision. Despite the expanding utility of ultrasound neuromodulation in the neuroscience research field and clinical applications, the molecular and cellular mechanisms by which ultrasound impacts neural activity in the brain are still largely unknown. Here, we report that transient receptor potential canonical 6 (TRPC6), a mechanosensitive...
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作者：Morotti, Ilaria; Caremani, Marco; Marcello, Matteo; Pertici, Irene; Squarci, Caterina; Bianco, Pasquale; Narayanan, Theyencheri; Piazzesi, Gabriella; Reconditi, Massimo; Lombardi, Vincenzo; Linari, Marco
作者单位：University of Florence; University of Florence; European Synchrotron Radiation Facility (ESRF); University of Florence
摘要：The regulation of heart function is attributed to a dual filament mechanism: i) the Ca2+-dependent structural changes in the regulatory proteins of the thin, actin-containing filament making actin available for myosin motor attachment, and ii) the release of motors from their folded (OFF) state on the surface of the thick filament allowing them to attach and pull the actin filament. Thick filament mechanosensing is thought to control the number of motors switching ON in relation to the systoli...
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作者：Nielsen, Ashley N.; Triplett, Regina L.; Bernardez, Lourdes M.; Tooley, Ursula A.; Herzberg, Max P.; Lean, Rachel E.; Kaplan, Sydney; Meyer, Dominique; Kenley, Jeanette K.; Alexopoulos, Dimitrios; Losielle, David; Latham, Aidan; Smyser, Tara A.; Agrawal, Arpana; Shimony, Josh S.; Jackson, Joshua J.; Miller, J. Philip; Raichle, Marcus E.; Warner, Barbara B.; Rogers, Cynthia E.; Sylvester, Chad M.; Barch, Deanna M.; Luby, Joan L.; Smyser, Christopher D.
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
摘要：Childhood exposure to social disadvantage is a major risk factor for psychiatric disorders and poor developmental, educational, and occupational outcomes, presumably because adverse exposures alter the neurodevelopmental processes that contribute to risk trajectories. Yet, given the limited social mobility in the United States and other countries, childhood social disadvantage is frequently preceded by maternal social disadvantage during pregnancy, potentially altering fetal brain development ...
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作者：Prada, Fiorella; Haramaty, Liti; Livnah, Oded; Shaul, Racheli; Abramovich, Sigal; Mass, Tali; Rosenthal, Yair; Falkowski, Paul G.
作者单位：Rutgers University System; Rutgers University New Brunswick; Hebrew University of Jerusalem; Ben-Gurion University of the Negev; University of Haifa; Rutgers University System; Rutgers University New Brunswick
摘要：Foraminifera are unicellular protists capable of precipitating calcite tests, which fossilize and preserve geochemical signatures of past environmental conditions dating back to the Cambrian period. The biomineralization mechanisms responsible for the mineral structures, which are key to interpreting palaeoceanographic signals, are poorly understood. Here, we present an extensive analysis of the test- bound proteins. Using liquid chromatography-tandem mass spectrometry, we identify 373 test- b...
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作者：Thirumalai, D.; Das, Rajsekhar; Li, Xin
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
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作者：Zhao, Liang; Gulati, Paarth; Caballero, Fernando; Kolvin, Itamar; Adkins, Raymond; Marchetti, M. Cristina; Dogic, Zvonimir
作者单位：University of California System; University of California Santa Barbara; Brandeis University; University System of Georgia; Georgia Institute of Technology; Yale University; University of California System; University of California Santa Barbara
摘要：We study the structure and dynamics of the interface separating a passive fluid from a microtubule-based active fluid. Turbulent-like active flows power giant interfacial fluctuations, which exhibit pronounced asymmetry between regions of positive and negative curvature. Experiments, numerical simulations, and theoretical arguments reveal how the interface breaks up the spatial symmetry of the fundamental bend instability to generate local vortical flows that lead to asymmetric interface fluct...
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作者：Lopez-Goldar, Xose; Zhang, Xuening; Hastings, Amy P.; Duplais, Christophe; Agrawal, Anurag A.
作者单位：Cornell University; Cornell University; Cornell University
摘要：Multiple hypotheses have been put forth to understand why defense chemistry in individual plants is so diverse. A major challenge has been teasing apart the importance of concentration vs. composition of defense compounds and resolving the mechanisms of diversity effects that determine plant resistance against herbivores. Accordingly, we first outline nonexclusive mechanisms by which phytochemical diversity may increase toxicity of a mixture compared to the average effect of each compound alon...
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作者：Chiang, Michael; Hopkins, Austin; Loewe, Benjamin; Marchetti, M. Cristina; Marenduzzo, Davide
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作者：Chiou, Katherine L.; Lira-Noriega, Andres; Gallaga, Emiliano; Hastorf, Christine A.; Aguilar-Melendez, Araceli
作者单位：University of Alabama System; University of Alabama Tuscaloosa; Instituto de Ecologia - Mexico; University of California System; University of California Berkeley; Universidad Veracruzana
摘要：This study investigates the temporal and spatial factors driving the domestication of Capsicum annuum var. annuum L. in Mexico. This species exhibits the greatest morphological diversity in fruit among Capsicum species-a characteristic that is even more pronounced in contemporary landraces cultivated by indigenous communities. Despite the chili pepper's integral role in regional culinary traditions, its domestication history in this region remains poorly understood, often subject to scholarly ...
