9期

最新文章

• Small molecule enoxacin is a cancer- specific growth inhibitor that acts by enhancing TAR RNA- binding protein 2- mediated microRNA processing (vol 108, pg 4394, 2011) AI翻译
  作者：Melo, Sonia; Villanueva, Alberto; Moutinho, Catia; Davalos, Veronica; Spizzo, Riccardo; Ivan, Cristina; Rossi, Simona; Setien, Fernando; Casanovas, Oriol; Simo-Riudalbas, Laia; Carmona, Javier; Carrere, Jordi; Vidal, August; Aytes, Alvaro; Puertas, Sara; Ropero, Santiago; Kalluri, Raghu; Croce, Carlo M.; Calin, George A.; Esteller, Manel
• Protective role of parenthood on age- related brain function in mid- to late- life AI翻译
  作者：Orchard, Edwina R.; Chopra, Sidhant; Ooi, Leon Q. R.; Chen, Pansheng; An, Lijun; Jamadar, Sharna D.; Yeo, B. T. Thomas; Rutherford, Helena J. V.; Holmes, Avram J.
  作者单位：Yale University; Yale University; Rutgers University System; Rutgers University New Brunswick; Orygen, The National Centre of Excellence in Youth Mental Health; Orygen, The National Centre of Excellence in Youth Mental Health; University of Melbourne; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; Monash University; Monash University
  摘要：The experience of human parenthood is near ubiquitous and can profoundly alter one's body, mind, and environment. However, we know very little about the long- term neural effects of parenthood for parents themselves, or the implications of pregnancy and caregiving experience on the aging adult brain. Here, we investigate the link between the number of children parented and age on brain function in 19,964 females and 17,607 males from the UK Biobank. In both females and males, parenthood was po...
• Weakening AMOC reduces ocean carbon uptake and increases the social cost of carbon AI翻译
  作者：Schaumann, Felix; de Asenjo, Eduardo Alastrue
  作者单位：University of Hamburg; Max Planck Society; University of Hamburg
  摘要：A weakening of the Atlantic Meridional Overturning Circulation (AMOC) has been found to be globally beneficial by economic assessments. This result emerges because AMOC weakening would cool the Northern Hemisphere, thereby reducing expected climate damages and decreasing estimates of the global social cost of carbon dioxide (SCC). There are, however, many other impacts of AMOC weakening that are not yet taken into account. Here, we add a second impact channel by quantifying the effects of AMOC...
• Rethinking postdoc careers through the science of science AI翻译
  作者：Wu, Youyou; Feng, Kaiyun
  作者单位：University of London; University College London; UCL Institute of Education; University of London; King's College London; University of Cambridge
• A numerically exact description of ultrafast vibrational decoherence in vibration-coupled electron transfer AI翻译
  作者：Wang, Yuanheng; Benny, Alfy; Le De, Brieuc; Chin, Alex W.; Scholes, Gregory D.
  作者单位：Princeton University; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS)
  摘要：Broadband pump-probe spectroscopy has been widely used to measure vibrational de- coherence associated with the reaction coordinate in photoinduced ultrafast vibration- coupled electron transfer (VCET) reactions. These experiments provide insight into the interplay of intramolecular coordinates along the reaction coordinate. However, a general theoretical foundation for analyzing, and even for explaining rigorously, these data is lacking. In this work, we study vibrational decoherence in a mod...
• No evidence for Peto's paradox in terrestrial vertebrates AI翻译
  作者：Butler, George; Baker, Joanna; Amend, Sarah R.; Pienta, Kenneth J.; Venditti, Chris
  作者单位：University of London; University College London; Johns Hopkins University; Johns Hopkins Medicine; University of Reading
  摘要：Larger, longer- lived species are expected to have a higher cancer prevalence compared to smaller, shorter- lived species owing to the greater number of cell divisions that occur during their lifespan. Yet, to date, no evidence has been found to support this expectation, and no association has been found between cancer prevalence and body size across species-a phenomenon known as Peto's paradox. Specifically, while anticancer mechanisms have been identified for individual species, wider phylog...
• Ectopic mouse TMC1 and TMC2 alone form mechanosensitive channels that are potently modulated by TMIE AI翻译
  作者：Chen, Yixuan; Li, Yulin; Liu, Yonghong; Sun, Jiawen; Feng, Wanying; Chen, Yanfei; Tian, Ye; Lei, Tianlun; Huang, Pingbo
  作者单位：Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology
  摘要：The mechanotransduction (MT) channel expressed in cochlear and vestibular hair cells converts the mechanical stimulation of sound and head movements into electrochemical signals. Recently, TMC1 and TMC2 (TMC1/2) have been recognized as the pore- forming subunit of the MT channel, but TMC1/2 functional expression in heterologous cells-which is critical for unequivocally identifying them as the bona fide pore- forming subunit of the MT channel-has not been achieved because ectopic TMC1/2 become ...
• The RNA- binding protein RBPMS inhibits smooth muscle cell- driven vascular remodeling in atherosclerosis and vascular injury AI翻译
  作者：Du, Jianlin; Yuan, Xin; Wang, Jiajia; Zhang, Lujun; Tan, Fangyan; Hu, Tianyang; Li, Xingsheng; Liu, Fan; Ran, Haitao; Wang, Zhigang; Li, Yongyong; Feng, Yuxing; Melgiri, N. D.; Cao, Yu; Jiang, Lihong; Huang, Rongzhong; Sun, Yang
  作者单位：Chongqing Medical University; Chongqing Medical University; Chongqing Medical University; Chongqing Medical University; Kunming University of Science & Technology; Kunming University of Science & Technology; Kunming University of Science & Technology
  摘要：Atherosclerosis and vessel wall trauma induce vascular smooth muscle cell (VSMC) phenotypic modulation, leading to plaque cap growth and postintervention restenosis. Our systems biology approach identified RNA binding protein, mRNA processing factor (RBPMS) as a conserved, VSMC- specific gene associated with VSMC modulation in atherosclerosis. RBPMS gene expression positively correlates with VSMC contractile markers in human and murine atherosclerotic arteries as well as in two vascular injury...
• Leaky ribosomal scanning enables tunable translation of bicistronic ORFs in green algae AI翻译
  作者：Duenas, Marco A.; Crai, Rory J.; Gallaher, Sean; Mosele, Jeffre L.; Merchant, Sabeeha S.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：Advances in sequencing technology have unveiled examples of nucleus- encoded polycistrons, once considered rare. Exclusively polycistronic transcripts are prevalent in green algae, although the mechanism by which multiple polypeptides are translated from a single transcript is unknown. Here, we used bioinformatic and in vivo mutational analyses to evaluate competing mechanistic models for translation of bicistronic mRNAs in green algae. High- confidence manually curated datasets of bicistronic...
• Chiral structural color from microdomes AI翻译
  作者：Lai, Xintao; Li, Tongyu; Hou, Xiaoyu; Vogelbacher, Florian; Wang, Jiajun; Song, Yanlin; Shi, Lei; Li, Mingzhu
  作者单位：Chinese Academy of Sciences; Technical Institute of Physics & Chemistry, CAS; Chinese Academy of Sciences; Institute of Chemistry, CAS; Fudan University; Fudan University; Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Boston University
  摘要：Artificial chiralstructural- color materials can carry high- dimensional information on multiple optical degrees of freedom, providing possibilities for advanced optical rity and information storage. However, current artificial chiralstructural- color materials are hindered by their specific compositions, fine nanostructures, and single polarization modulation. Here, we found that microdomes made from common polymers have structural colors with broadband tunability and multiple polarization- m...