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作者：Ahituv, Hadar; Henry, Amanda G.; Melamed, Yoel; Goren-Inbar, Naama; Bakels, Corrie; Shumilovskikh, Lyudmila; Cabanes, Dan; Stone, Jeffery R.; Rowe, Walter F.; Alperson-Afil, Nira
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作者：Schnyder, Simon K.; Molina, John J.; Yamamoto, Ryoichi; Turner, Matthew S.
作者单位：University of Tokyo; Kyoto University; University of Warwick; University of Warwick
摘要：Faced with a dangerous epidemic humans will spontaneously social distance to reduce their risk of infection at a socioeconomic cost. Compartmentalized epidemic models have been extended to include this endogenous decision making: Individuals choose their behavior to optimize a utility function, self-consistently giving rise to population behavior. Here, we study the properties of the resulting Nash equilibria, in which no member of the population can gain an advantage by unilaterally adopting ...
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作者：Huang, Rongbing; Ting, Alice Y.
作者单位：Stanford University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
摘要：Efficient methods for conjugating proteins to RNA are needed for RNA delivery, imaging, editing, interactome mapping, and barcoding applications. Noncovalent coupling strategies using viral RNA binding proteins such as MS2/MCP have been widely applied but are limited by tag size, sensitivity, and dissociation over time. We took inspiration from a sequence- specific, covalent protein-DNA conjugation method based on the Rep nickase of a porcine circovirus called HUH tag. Though wild- type HUH pr...
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作者：Crossley, Michael; Simon, Anna; Marathe, Shashidhara; Rau, Christoph; Roth, Arnd; Marra, Vincenzo; Staras, Kevin
作者单位：University of Sussex; University of London; University College London; Diamond Light Source
摘要：Molluscan brains are composed of morphologically consistent and functionally interrogable neurons, offering rich opportunities for understanding how neural circuits drive behavior. Nonetheless, detailed component- level CNS maps are often lacking, total neuron numbers are unknown, and organizational principles remain poorly defined, limiting a full and systematic characterization of circuit operation. Here, we establish an accessible, generalizable approach, harnessing synchrotron X- ray tomog...
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作者：Guo, Xiao; Dong, Xinyu; Zou, Guijin; Zhang, Haoqi; Zeng, Kaiyang; Gao, Huajian; Zhai, Wei
作者单位：National University of Singapore; Nanyang Technological University; Tsinghua University
摘要：Mimicking hierarchical structures found in nature, such as nacre and tendon, has led to remarkable successes in the creation of biomimetic materials with exceptional properties. The depth of knowledge derived from nature extends far beyond mere trial- and- error fabrication by providing deep insights into the toughening mechanisms that are integral to natural materials. A key challenge is understanding how these toughening mechanisms can be effectively translated into biomimetic materials. Her...
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作者：Rusconea, Guido Alberto Gnecchi-; Racz, Zsofia; Liccardo, Salvatore; Lee, Juhyeon; Huang, Yilei; Traverso, Luca; Radzeviciute, Rita; Hajnal, Zsuzsanna; Szecsenyi-Nagy, Anna; Gyuris, Balazs; Mateovics-Laszlo, Orsolya; Bernert, Zsolt; Szeniczey, Tamas; Hajdu, Tamas; Meszaros, Boglarka; Balint, Marianna; Mende, Balazs Gusztav; Miller, Bryan; Samashev, Zainolla; Childebayeva, Ainash; Djansugurova, Leyla; Geary, Patrick; Ringbauer, Harald; Vida, Tivadar; Jeong, Choongwon; Pohl, Walter; Krause, Johannes; Hofmanova, Zuzana
作者单位：Max Planck Society; Masaryk University; Eotvos Lorand University; University of Vienna; Austrian Academy of Sciences; Seoul National University (SNU); Seoul National University (SNU); Eotvos Lorand University; Eotvos Lorand University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Texas System; University of Texas Austin; Institute of Zoology in Kazakhstan; Institute for Advanced Study - USA
摘要：The Huns appeared in Europe in the 370s, establishing an Empire that reshaped West Eurasian history. Yet until today their origins remain a matter of extensive debate. Traditional theories link them to the Xiongnu, the founders of the first nomadic empire of the Mongolian steppe. The Xiongnu empire dissolved, however, similar to 300 y before the Huns appeared in Europe, and there is little archaeological and historical evidence of Huns in the steppe during this time gap. Furthermore, despite t...
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作者：Starostecka, Maja; Jeong, Hyobin; Hasenfeld, Patrick; Garagorri, Eva Benito -; Christiansen, Tania; Brasseur, Catherine Stober; Queiroz, Maise Gomes; Montero, Marta Garcia; Jechlinger, Martin; Korbel, Jan O.
作者单位：Bristol-Myers Squibb; European Molecular Biology Laboratory (EMBL); Yonsei University; Helmholtz Association; German Cancer Research Center (DKFZ); European Molecular Biology Laboratory (EMBL)
摘要：The most common chemotherapeutics induce DNA damage to eradicate cancer cells, yet defective DNA repair can propagate mutations, instigating therapy resistance and secondary malignancies. Structural variants (SVs), arising from copy- number- imbalanced and - balanced DNA rearrangements, are a major driver of tumor evolution, yet understudied posttherapy. Here, we adapted single- cell with nucleosome occupancy (NO) measurements obtained from the same single cell to enable simultaneous SV detect...
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作者：Jenewein, Christian; Maiz-Sicilia, Aurora; Rull, Fernando; Gonzalez-Souto, Lorena; Garcia-Ruiz, Juan Manuel
作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto Andaluz de Ciencias de la Tierra (IACT); Universidad de Valladolid; Universidad de Cadiz
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作者：Cheng, Yang; Wang, Xuesong; Ding, Yike; Zhang, Houhong; Jia, Zhenyu; Raikhel, Alexander S.
作者单位：University of California System; University of California Riverside; University of California System; University of California Riverside; Yangzhou University; University of California System; University of California Riverside; University of California System; University of California Riverside
摘要：Female mosquitoes are vectors of many devastating human diseases because they require blood feeding to initiate reproduction. Thus, elucidation of molecular mechanisms managing female mosquito reproduction is essential. Although the regulation of gene expression during the mosquito gonadotrophic cycle has been studied in detail, how this process is controlled at the chromatin level remains unclear. Chromatin must be accessible for transcription factors (TFs) governing gene expression. A specia...
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作者：Ho, Kate; Pakes, Ariel
作者单位：Princeton University; National Bureau of Economic Research; Harvard University; National Bureau of Economic Research
摘要：Current proposals aimed at reducing U.S. pharmaceutical prices would have immediate benefits (particularly for low-income and elderly populations), but could dramatically reduce firms' investment in potentially highly welfare-improving Research and Development (R&D). The United States subsidizes the worldwide pharmaceutical market: U.S. drug prices are more than 250% of those in other Organization for Economic Co-operation and Development (OECD) countries. If each drug had a single internation...
