9期

最新文章

• Critical fragility in sociotechnical systems AI翻译
  作者：Moran, Jose; Pijpers, Frank P.; Weitzel, Utz; Bouchaud, Jean-Philippe; Panja, Debabrata
  作者单位：University of Oxford; University of Amsterdam; Vrije Universiteit Amsterdam; Radboud University Nijmegen; Utrecht University; Utrecht University
  摘要：Sociotechnical systems, where technological and human elements interact in a goal-oriented manner, provide important functional support to our societies. Here, we draw attention to the underappreciated concept of timeliness-i.e., system elements being available at the right place at the right time-that has been ubiquitously and integrally adopted as a quality standard in the modus operandi of sociotechnical systems. We point out that a variety of incentives, often reinforced by competitive pre...
• Bipartite binding of the intrinsically disordered scaffold protein JIP1 to the kinase JNK1 AI翻译
  作者：Orand, Thibault; Delaforge, Elise; Lee, Alexandra; Kragelj, Jaka; Maud, Tengo; Tengo, Laura; Blackledge, Martin; Erba, Elisabetta Boeri; Davis, Roger JD.; Palencia, Andres; Jensen, Malene Ringkjobing
  作者单位：National Institute of Chemistry - Slovenia; European Molecular Biology Laboratory (EMBL); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CEA; Centre National de la Recherche Scientifique (CNRS); University of Massachusetts System; University of Massachusetts Worcester; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
  摘要：Scaffold proteins are key players in many signaling pathways where they ensure spatial and temporal control of molecular interactions by simultaneous tethering of multiple signaling components. The protein JIP1 acts as a scaffold within the c- Jun N- terminal kinase (JNK) signaling pathway by assembling three kinases, MLK3, MKK7, and JNK, into a macromolecular complex that enables their specific activation. The recruitment of these kinases depends on the 450- amino acid intrinsically disordere...
• Physics- informed deep learning for stochastic particle dynamics estimation AI翻译
  作者：Zhang, Yongyu; Zhu, Junlun; Xie, Hao; He, Yan
  作者单位：Tsinghua University; Chinese Academy of Sciences; Institute of Physics, CAS
  摘要：Single- particle tracking has enabled quantitative studies of complex systems, providing nanometer localization precision and millisecond temporal resolution in heterogeneous environments. However, at micro- or nanometer scales, probe dynamics become inherently stochastic due to Brownian motion and complex interactions, leading to varied diffusion behaviors. Typically, analysis of such trajectory data involves certain moving- window operation and assumes the existence of some pseudo-steady sta...
• A bipartite interaction with the processivity clamp potentiates Pol IV- mediated TLS AI翻译
  作者：Chang, Seungwoo; Laureti, Luisa; Thrall, Elizabeth S.; Kay, Marguerite S.; Philippin, Gaelle; Jergic, Slobodan; Pages, Vincent; Loparo, Joseph J.
  作者单位：Fordham University; Brandeis University; Harvard University; Harvard Medical School; UNICANCER; Institut Paoli-Calmette (IPC); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; University of Wollongong
  摘要：Processivity clamps mediate polymerase switching for translesion synthesis (TLS). All three Escherichia coli TLS polymerases interact with the (32 processivity clamp through a conserved clamp- binding motif (CBM), which is indispensable for TLS. Notably, Pol IV also interacts weakly with the rim of the clamp through non-CBM residues. Ablating this rim contact in cells results in selective sensitivity to DNA- damaging agents, raising the question how the rim contact contributes to TLS. Here, we...
• The synergistic effect of c-Myb hyperactivation and Pu.1 deficiency induces Pelger-Huët anomaly and promotes sAML AI翻译
  作者：Xu, Song'en; Hong, Jiaxin; Dongye, Meimei; Lin, Jiehao; Xue, Rongtao; Huang, Zhibin; Xu, Jin; Zhang, Yiyue; Leung, Anskar Yu- Hung; Shen, Juan; Zhang, Wenqing; Liu, Wei
  作者单位：South China University of Technology; Sun Yat Sen University; Southern Medical University - China; University of Hong Kong; Guangdong Pharmaceutical University; Guangdong Pharmaceutical University
  摘要：Approximately 30% of patients with myelodysplastic syndrome (MDS) progress to secondary acute myeloid leukemia (sAML) via accumulating gene mutations. Genomic analyses reveal a complex interplay among mutant genes, with co- occurring and mutually exclusive patterns. Hyperactivation of c-MYB and deficiency of PU.1 have been linked to myeloid disorders. We report a case of AML with concurrent PU.1 and c-MYB mutations, exhibiting early onset, high blast count, chemo- resistance, indicating high- ...
• Radiation- induced cellular plasticity primes glioblastoma for forskolin- mediated differentiation AI翻译
  作者：He, Ling; Azizad, Daria; Bhat, Kruttika; Ioannidis, Angeliki; Hoffmann, Carter J.; Arambula, Evelyn; Eghbali, Mansoureh; Bhaduri, Aparna; Kornblum, Harley I.; Pajonk, Frank
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; UCLA Jonsson Comprehensive Cancer Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：Glioblastoma (GBM) is the deadliest brain cancer in adults, and all patients succumb to the tumor. While surgery followed by chemoradiotherapy delays disease progression, these treatments do not lead to tumor control, and targeted therapies or biologics have failed to further improve survival. Utilizing a transient radiation- induced state of multipotency, we used the adenylcyclase activator forskolin to alter the fate of irradiated glioma cells. The effects of the combined treatment on neuron...
• 3A or not 3A: Cytidine deaminases in the etiology of the CAG- repeat expansion diseases AI翻译
  作者：Usdin, Karen
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
• Van der Waals quantum dots on layered hexagonal boron nitride AI翻译
  作者：Wu, Yuanpeng; Xiao, Yixin; Zhao, Ying; Shen, Yifan; Sun, Kai; Wang, Boyu; Wang, Ping; Wang, Ding; Zhou, Peng; Wang, Danhao; Liu, Jiangnan; Hu, Mingtao; Norris, Theodore B.; Song, Jun; Mi, Zetian
  作者单位：University of Michigan System; University of Michigan; McGill University; University of Michigan System; University of Michigan
  摘要：Semiconductor quantum dots (QD) promise unique electronic, optical, and chemical properties, which can be exquisitely tuned by controlling the composition, size, and morphology. Semiconductor QDs have been synthesized primarily via two approaches, namely, epitaxial growth and wet- chemical synthesis. However, the properties of epitaxial QDs (eQDs) are susceptible to wetting layer formation and substrate dislocations, while colloidal QDs (cQDs) face fluorescence intermittency issues. Here, we r...
• Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration AI翻译
  作者：Sahoo, Pabitra K.; Agrawal, Manasi; Hanovice, Nicholas; Ward, Patricia J.; Desai, Meghal; Smith, Terika P.; Sima, HaoMin; Dulin, Jennifer N.; Vaughn, Lauren S.; Tuszynski, Mark H.; Welshhans, Kristy; Benowitz, Larry I.; English, Arthur W.; Houle, John D.; Twiss, Jeffery L.
  作者单位：University of South Carolina System; University of South Carolina Columbia; Rutgers University System; Rutgers University Newark; University System of Ohio; Kent State University; Kent State University Salem; Kent State University Kent; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Emory University; University of California System; University of California San Diego; Texas A&M University System; Texas A&M University College Station; University of South Carolina System; University of South Carolina Columbia; Drexel University
  摘要：Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2 in Caenorhabditis elegans, increases the growth of spontaneously regenerating axons. Inhibition of G3BP1 by expression of its acidic or B-domain accelerates axon regeneration after nerve injury, bringing a potential therapeutic strategy for peripheral nerve repair. Here, we asked whether G3BP1 inhibition is a viable strategy to promote regeneration in injured mammalian central nervous system (CNS) where axons ...
• Measuring criticism of the police in the local news media using large language models AI翻译
  作者：Crowl, Logan; Dutta, Sujan; Khudabukhsh, Ashiqur R.; Severnini, Edson; Nagin, Daniel S.
  作者单位：Carnegie Mellon University; Carnegie Mellon University; Rochester Institute of Technology; Boston College
  摘要：High-profile incidents of police violence against Black citizens over the past decade have spawned contentious debates in the United States on the role of police. This debate has played out prominently in the news media, leading to a perception that media outlets have become more critical of the police. There is currently, however, little empirical evidence supporting this perceived shift. We construct a large dataset of local news reporting on the police from 2013 to 2023 in 10 politically di...