9期

最新文章

• Hapalindole Q suppresses autophagosome-lysosome fusion by promoting YAP1 degradation via chaperon- mediated autophagy (vol 121, e2400809121,2024) AI翻译
  作者：Wu, Yali; Wang, Shaonan; Guo, Zhicong; Sun, Min; Xu, Zhen; Du, Yu; Zhu, Fahui; Su, Yajuan; Xu, Zhou; Xu, Yi; Gong, Xu; Fang, Ruan; Hu, Jiaojiao; Peng, Yan; Ding, Zhaowen; Liu, Cong; Li, Ang; He, Weiwei
• Empowering genome- wide association studies via a visualizable test based on the regional association score AI翻译
  作者：Jiang, Yiran; Zhang, Heping
  作者单位：Yale University
  摘要：The genome- wide association studies identified genes associated with many diseases, but the identification and verification of disease variants are still challenging due to small effects and large number of individual variants. In this paper, we propose a powerful method that first quantifies the strength of regional associations at each single nucleotide polymorphism and converts these measures into time series data before using a change point detection algorithm to identify significant regi...
• Direct control of electron spin at an intrinsically chiral surface for highly efficient oxygen reduction reaction AI翻译
  作者：Wang, Xia; Peralta, Mayra; Li, Xiaodong; Moellers, Paul, V; Zhou, Dong; Merz, Patrick; Burkhardt, Ulrich; Borrmann, Horst; Shekhar, Chandra; Zacharias, Helmut; Feng, Xinliang; Felser, Claudia
  作者单位：Max Planck Society; Technische Universitat Dresden; Technische Universitat Dresden; University of Munster; Tsinghua Shenzhen International Graduate School; Tsinghua University; Max Planck Society
  摘要：The oxygen reduction reaction (ORR) in acidic media suffers from sluggish kinetics, primarily due to the spin- dependent electron transfer involved. The direct generation of spin- polarized electrons at catalytic surfaces remains elusive, and the underlying mechanisms are still controversial due to the lack of intrinsically chiral catalysts. To address this challenge, we investigate topological homochiral PdGa (TH PdGa) crystals with intrinsically chiral catalytic surfaces for ORR. Through spi...
• Multiomics analysis unveils the cellular ecosystem with clinical relevance in aldosterone- producing adenomas with KCNJ5 mutations AI翻译
  作者：Yokomoto-Umakoshi, Maki; Fujita, Masamichi; Umakoshi, Hironobu; Ogasawara, Tatsuki; Iwahashi, Norifusa; Nakatani, Kohta; Kaneko, Hiroki; Fukumoto, Tazuru; Nakao, Hiroshi; Haji, Shojiro; Kawamura, Namiko; Shimma, Shuichi; Seki, Masahide; Suzuki, Yutaka; Izumi, Yoshihiro; Oda, Yoshinao; Eto, Masatoshi; Ogawa, Seishi; Bamba, Takeshi; Ogawa, Yoshihiro
  作者单位：Kyushu University; Kyushu University; University of Osaka; University of Tokyo; Kyushu University; Kyushu University; Kyoto University
  摘要：Aldosterone- producing adenomas (APA), a major endocrine tumor and leading subtype of primary aldosteronism, cause secondary hypertension with high cardiometabolic risks. Despite potentially producing multiple steroid hormones, detailed cellular mechanisms in APA remain insufficiently studied. Our multiomics analysis focusing on APA with KCNJ5 mutations, which represent the most common genetic form, revealed marked cellular heterogeneity.Tumor cell reprogramming initiated from stress- responsi...
• O- GalNAc glycans are enriched in neuronal tracts and regulate nodes of Ranvier AI翻译
  作者：Noel, Maxence; Suttapitugsakul, Suttipong; Cummings, Richard D.; Mealer, Robert G.
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：Protein O-glycosylation is a critical modification in the brain, as genetic variants in the pathway are associated with common and severe neuropsychiatric phenotypes. However, little is known about the most abundant O- glycans in the mammalian brain, which are N- acetylgalactosamine (O- GalNAc) linked. Here, we determined the spatial localization, protein carriers, and cellular function of O- GalNAc glycans in the mouse brain. We observed striking spatial enrichment of O- GalNAc glycans in neu...
• Limited and biased global conservation funding means most threatened species remain unsupported AI翻译
  作者：Guenard, Benoit; Hughes, Alice C.; Laine, Claudianne; Cannicci, Stefano; Russell, Bayden D.; Williams, Gray A.
  作者单位：University of Hong Kong; University of Florence; University of Hong Kong; University of Hong Kong
  摘要：The conservation of biodiversity represents a global challenge as the world experiences its sixth mass extinction. Understanding how conservation efforts are allocated is paramount to effectively protect threatened species. We analyzed similar to 14,600 conservation projects over a 25- y period, revealing substantial taxonomic biases in funding. When matched with formal assessments of species' threat status, several highly threatened groups such as amphibians receive little and ever- decreasin...
• RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells AI翻译
  作者：Narasimhan, Hamsa; Richter, Maria L.; Shakiba, Ramin; Papaioannou, Nikos E.; Stehle, Christina; Rengarajan, Kaushikk Ravi; Ulmert, Isabel; Kendirli, Arek; de la Rosa, Clara; Kuo, Pin-Yu; Altman, Abigail; Muench, Philipp; Mahboubi, Saba; Kuentzel, Vanessa; Sayed, Amina; Stange, Eva-Lena; Pes, Jonas; Antonova, Alina Ulezko; Pereira, Carlos-Filipe; Klein, Ludger; Dudziak, Diana; Colonna, Marco; Torow, Natalia; Hornef, Mathias W.; Clausen, Bjoern E.; Kerschensteiner, Martin; Lahl, Katharina; Romagnani, Chiara; Colome-Tatche, Maria; Schraml, Barbara U.
  作者单位：University of Munich; University of Munich; University of Munich; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Technical University of Denmark; University of Munich; University of Munich; University of Munich; University of Munich; Lund University; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; RWTH Aachen University; RWTH Aachen University Hospital; Washington University (WUSTL); Friedrich Schiller University of Jena; University of Calgary; University of Calgary; Academy of Athens; Helmholtz Association; Helmholtz-Center for Infection Research
  摘要：Conventional dendritic cells (cDCs) are potent antigen- presenting cells (APCs) that integrate signals from their environment allowing them to direct situation- adapted immunity. Thereby they harbor great potential for being targeted in vaccination, autoimmunity, and cancer. Here, we use fate mapping, functional analyses, and comparative cross- species transcriptomics to show that ROR gamma t+DCs are a conserved, functionally versatile, and transcriptionally distinct type of DCs. ROR gamma t+ ...
• pTDP-43 levels correlate with cell type-specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients AI翻译
  作者：Wang, Hsiao-Lin V.; Xiang, Jian - Feng; Yuan, Chenyang; Veire, Austin M.; Gendron, Tania F.; Murray, Melissa E.; Tarse, Malu G.; Hu, Jian; Gearing, Marla; Glass, Jonathan D.; Jin, Peng; Corces, Victor G.; Mceachin, Zachary T.
  作者单位：Emory University; Emory University; Emory University; Rollins School Public Health; Mayo Clinic; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Emory University; Emory University
  摘要：Repeat expansions in the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis and familial frontotemporal dementia (ALS/FTD). To identify molecular defects that take place in the dorsolateral frontal cortex of patients with C9orf72ALS/FTD, we compared healthy controls with C9orf72ALS/FTD donor samples staged based on the levels of cortical phosphorylated TAR DNA binding protein (pTDP-43), a neuropathological hallmark of disease progression. We identified distinct mol...
• Erythroid progenitor cell-mediated spleen-tumor interaction deteriorates cancer immunity AI翻译
  作者：Wu, Zhi- Zhong; Deng, Wei- Wei; Zhu, Su- Wen; Wang, Wen - Da; Wang, Shuo; Yang, Qi- Chao; Li, Hao; Mao, Liang; Chen, Wanjun; Sun, Zhi- Jun
  作者单位：Wuhan University; Wuhan University; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR)
  摘要：Understanding both local and systemic immunity is essential to optimizing the effectiveness of immunotherapy. However, the dynamic alterations in systemic immunity during tumor development are yet to be clearly defined. Here, we identified a previously unrecognized connection that bridges the interaction between the spleen and tumor through erythroid progenitor cells (EPCs), which suppress tumor immunity and promote tumor progression. We performed the single- cell RNA-seq and RNA-seq to demons...
• S- Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB- dependent gene expression induced by neuronal activity AI翻译
  作者：Zhang, Xu; Vlkolinsky, Roman; Wu, Chongyang; Dolatabadi, Nima; Scott, Henry; Prikhodko, Olga; Zhang, Andrew; Blanco, Mayra; Lang, Nhi; Pina-Crespo, Juan; Nakamura, Tomohiro; Roberto, Marisa; Lipton, Stuart A.
  作者单位：Scripps Research Institute; Scripps Research Institute; Scripps Research Institute; University of California System; University of California San Diego
  摘要：cAMP response element- binding protein (CREB)- regulated transcription coactivator 1 (CRTC1) plays an important role in synaptic plasticity, learning, and long- term memory formation through the regulation of neuronal activity- dependent gene expression, and CRTC1 dysregulation is implicated in Alzheimer's disease (AD). Here, we show that increased S- nitrosylation of CRTC1 (forming SNO- CRTC1), as seen in cell- based, animal- based, and human- induced pluripotent stem cell (hiPSC)- derived ce...