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作者：Chang, Sun Hyun; George, Wesley J.; Nelson, David C.
作者单位：University of California System; University of California Riverside
摘要：SMAX1-LIKE (SMXL) proteins in plants are cellular signaling hubs, many of which are posttranslationally regulated by karrikins from smoke, the plant hormones strigolactones (SLs), and/or cues such as light and nutrients. SMXL proteins control diverse aspects of growth, development, and environmental adaptation in plants through transcriptional corepression and interactions with transcriptional regulator proteins. In flowering plants, the SMXL family comprises four phylogenetic clades with diff...
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作者：Woodward, Claire H.; Chaudhuri, Apala; Chen, Xiaojing Tina; White, William L.; Garcia, K. Christopher; Baker, David; Sgourakis, Nikolaos G.
作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Howard Hughes Medical Institute; Stanford Medicine; Stanford University; University of Washington; University of Washington Seattle; University of Washington; Howard Hughes Medical Institute; University of Washington Seattle
摘要：Recognition of epitopic peptide antigens presented on class I major histocompatibility complex (MHC- I) proteins by T cell receptors (TCRs) forms the cornerstone of immune surveillance, leading to a plethora of adaptive immune responses. Characterization of TCR:peptide/MHC- I interactions is critical for understanding immune recognition, and developing immunotherapies, but the large variation in docking orientations of TCRs on their peptide/MHC- I targets challenges structural modeling. NMR sp...
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作者：Godfrey, Laurie R.; Samonds, Karen E.
作者单位：University of Massachusetts System; University of Massachusetts Amherst; Northern Illinois University
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作者：Gozzi, Nicolo; Perra, Nicola; Vespignani, Alessandro
作者单位：Northeastern University; University of London; Queen Mary University London; Alan Turing Institute
摘要：Characterizing the feedback linking human behavior and the transmission of infectious diseases (i.e., behavioral changes) remains a significant challenge in computational and mathematical epidemiology. Existing behavioral epidemic models often lack real-world data calibration and cross-model performance evaluation in both retrospective analysis and forecasting. In this study, we systematically compare the performance of three mechanistic behavioral epidemic models across nine geographies and t...
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作者：Huang, Xin; Li, Fangxia; Liu, Lin; Li, Yanxia; Zhang, Mengmeng; Ma, Guoming; Gao, Ying; Shan, Bing; Liang, Xiaozhen; Yuan, Junying; Pan, Heling
作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS
摘要：Necroptosis and apoptosis are two alternatively regulated cell death pathways. Activation of RIPK1 upon engagement of TNFR1 by TNF alpha may promote necroptosis by interacting with RIPK3 or apoptosis by activating caspases. RIPK1 is extensively regulated by a variety of dynamic posttranslational modifications which control its kinase activity and formation of downstream complexes to mediate necroptosis and apoptosis. Here, we investigate the functional significance and mechanism by which PARP1...
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作者：Sun, Xiang; Li, Huan; Chen, Zhan- Bo; Liu, Bing- Qi; Li, Chu- Qiao; Zhao, Zheng- Yang; Li, Xing-Ye; Luan, Jun-Bo
作者单位：Shenyang Agricultural University; Shenyang Agricultural University
摘要：Although it is widely recognized that nutritional symbionts can manipulate host reproduction, the underlying molecular and cellular mechanisms are largely unclear. The facultative symbiont Hamiltonella in bacteriocyte induces female-biased sex ratio of whiteflies. Here, we demonstrate that a maternal gene tudor (tud) and its encoded protein have lower expression levels in ovaries of Hamiltonella-cured whiteflies. Tud family proteins can interlink the various stages of biosynthesis of PIWI-inte...
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作者：He, Xiaoqing; Wu, Yi; Shu, Peng; Yin, Yanpeng; Deng, Heng; Ying, Shiyu; Wu, Mengbo; Zhao, Panpan; Huang, Tengbo; Pirrello, Julien; Zhang, Yang; Grierson, Don; Zhong, Zhenhui; Hong, Yiguo; Bouzayen, Mondher; Liu, Mingchun
作者单位：Sichuan University; Communaute d'universites et etablissements de Toulouse (Comue); Universite de Toulouse (EPE); Shenzhen University; University of Nottingham; University of Warwick; Hebei Agricultural University
摘要：Improving fruit growth and quality without compromising yield is a highly sought-after goal in crop breeding. Here, we report that an EAR motif-containing transcription factor SlPLT6 controls the onset of fruit ripening and quality traits in tomato. SlPLT6 knockout caused precocious ripening initiation and enhanced fruit qualities without penalizing yield in two tomato cultivars. SlPLT6 represses genes involved in ripening initiation and major quality traits by directly binding to their promot...
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作者：Suter, Thomas; Friedman, Meyer J.; Tazearslan, Cagdas; Merkurjev, Daria; Ohgi, Kenny; Meluzzi, Dario; Rosenfeld, Michael G.; Suh, Yousin
作者单位：University of California System; University of California San Diego; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital
摘要：Cellular senescence, a major contributor to aging and age-related pathologies, is characterized by irreversible proliferative arrest and a disease-linked, proinflammatory profile known as the Senescence Associated Secretory Phenotype (SASP). A critical unanswered question is whether these properties are regulated by specific enhancer subsets, potentially licensing strategies that selectively block deleterious SASP components. Here, we identify two functionally distinct and independently regula...
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作者：Takata, Mamoru; Takahashi, Michihiko; Ishibashi, Tomoki; Tasaki, Eisuke; Rueppell, Olav; Vargo, Edward L.; Matsuura, Kenji
作者单位：Kyoto University; University of Alberta; Texas A&M University System; Texas A&M University College Station; National Institute of Advanced Industrial Science & Technology (AIST); RIKEN; Niigata University
摘要：The discovery of transgenerational epigenetic inheritance and the unraveling of its molecular mechanisms are currently solving previously puzzling challenges that Mendelian genetics based solely on DNA could not explain, leading to significant paradigm shifts across various fields of biology. There has been a long-standing controversy over the factors determining the caste fate of individuals in social insects. Increasing evidence supports heritable influences on division of labor. Here, we pr...
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作者：Mostofa, Mohammad Golam; Sahu, Abira; Xu, Yuan; Basrai, Insiya; Doron, Lior; Lefrancois, Violet; Sharkey, Thomas D.
作者单位：United States Department of Energy (DOE); Michigan State University; Michigan State University; Michigan State University; State University of New York (SUNY) System; University at Albany, SUNY; State University of New York (SUNY) College of Environmental Science & Forestry; SUNY Maritime College; University of Alabama System; University of Alabama Birmingham
摘要：Isoprene is the most abundant nonmethane biogenic hydrocarbon emitted by some plants, mostly trees. It plays critical roles in atmospheric chemistry by contributing to ozone and aerosol formation. Isoprene also benefits plants, particularly under stress, through its signaling roles. Legume crops like soybean were thought to have evolutionarily lost isoprene synthase (ISPS) and are typically considered nonemitters. Here, we report that damage to soybean leaves by wounding or burning triggered a...
