24期

最新文章

• Electrical spinal cord stimulation promotes focal sensorimotor activation that accelerates brain-computer interface skill learning AI翻译
  作者：Alawieh, Hussein; Liu, Deland; Madera, Jonathan; Kumar, Satyam; Racz, Frigyes Samuel; Fey, Ann Majewicz; Millan, Jose del R.
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
  摘要：Injuries affecting the central nervous system may disrupt neural pathways to muscles causing motor deficits. Yet the brain exhibits sensorimotor rhythms (SMRs) during movement intents, and brain-computer interfaces (BCIs) can decode SMRs to control from the instability of SMRs, requiring longitudinal training for users to learn proper transcutaneous electrical spinal stimulation (TESS) to inhibit the motor cortex prior provide promising possibilities for advancing BCI-based motor rehabilitation.
• Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis AI翻译
  作者：Berenbaum, May R.
• Macroevolutionary analysis of polysynthesis shows that language complexity is more likely to evolve in small, isolated populations AI翻译
  作者：Bromham, Lindell; Yaxley, Keaghan; Wilson, Oscar; Hua, Xia
  作者单位：Australian National University; Australian National University
  摘要：Evolution of complexity in human languages has been vigorously debated, including the proposal that complexity can build in small, isolated populations but is often lost in situations of language contact. If it is generally true that small, isolated languages can build morphological complexity over time, but complexity tends to be lost in situations of language contact, then we should find that forms of language complexity that have evolved multiple times will tend to be associated with popula...
• Predicting high-fitness viral protein variants with Bayesian active learning and biophysics AI翻译
  作者：Huot, Marian; Wang, Dianzhuo; Liu, Jiacheng; Shakhnovich, Eugene I.
  作者单位：Harvard University; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Universite Paris Cite; Sorbonne Universite; Ecole Normale Superieure (ENS); Harvard University; University of Washington; University of Washington Seattle
  摘要：The early detection of high-fitness viral variants is critical for pandemic response, yet limited experimental resources at the onset of variant emergence hinder effective identification. To address this, we introduce an active learning framework, VIRAL (Viral Identification via Rapid Active Learning), that integrates protein language model, Gaussian process with uncertainty estimation, and a biophysical model to predict the fitness of novel variants in a few-shot learning setting. By benchmar...
• A plant Lysin Motif Receptor-Like Kinase plays an ancestral function in mycorrhiza AI翻译
  作者：Teyssier, Eve; Grat, Sabine; Landry, David; Ouradou, Mathilde; Rich, Melanie K.; Fort, Sebastien; Keller, Jean; Lefebvre, Benoit; Delaux, Pierre - Marc; Mbengue, Malick
  作者单位：Universite de Toulouse (EPE); Communaute d'universites et etablissements de Toulouse (Comue); Centre National de la Recherche Scientifique (CNRS); Institut National Polytechnique de Toulouse; INRAE; Communaute d'universites et etablissements de Toulouse (Comue); Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Centre National de la Recherche Scientifique (CNRS); Universite Grenoble Alpes (UGA)
  摘要：Arbuscular mycorrhiza (AM) with soilborne Glomeromycota fungi was pivotal in the conquest of land by plants almost half a billion years ago. In flowering plants, it is hypothesized that AM is initiated by the perception of AM fungi-derived chito-and lipochito-oligosaccharides (COs/LCOs) in the host via Lysin Motif Receptor-Like Kinases (LysM-RLKs). However, it remains uncertain whether plant perception of these molecules is a prerequisite for AM establishment and for its origin. Here, we made ...
• Synergistic hydrogen embrittlement in high- strength steels AI翻译
  作者：Li, Zhi; Lu, Yiran; Gao, Huajian; Kumar, Sharvan
  作者单位：Nanyang Technological University; Brown University; Tsinghua University
  摘要：Hydrogen embrittlement (HE) remains a critical scientific challenge in building reliable infrastructure for a carbon-free hydrogen economy. Predictive models for hydrogen-induced material failure are still lacking, largely due to an incomplete understanding of hydrogen's effects on deformation behavior, especially in multiphase alloys with complex compositions and microstructures. Here, we demonstrate a synergistic hydrogen embrittlement (SHE) phenomenon in high-strength martensitic steels, wh...
• Reproductive state controls transcription in the murine liver, with implications for breast cancer liver metastasis AI翻译
  作者：Ozaki, Michelle K.; Zhang, Yi; Bartlett, Alexandra Q.; de Wilde, Elise; Guan, Xiangnan; Yang, Alex; Xia, Zheng; Schedin, Pepper
  作者单位：Oregon Health & Science University; Oregon Health & Science University
  摘要：Liver biology is functionally linked to lactation, as liver size and metabolic output increase during lactation to support synthesis of breast milk. Upon weaning, the rodent liver returns to baseline homeostasis via hepatocyte cell death, in a process considered liver involution. To explore liver biology changes across a lactation-wean cycle, we employed transcriptomic profiling. We identified elevated hepatocyte proliferation and anabolic metabolism gene signatures during lactation, consisten...
• Measuring historical pollution: Natural history collections as tools for public health and environmental justice research AI翻译
  作者：DuBay, Shane; Weeks, Brian C.; Davis-Kean, Pamela E.; Fuldner, Carl; Harris, Nyeema C.; Hughes, Sara; O'Brien, Bruce; Perkins, Marie; Weyant, Cheryl
  作者单位：University of Texas System; University of Texas Arlington; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Chicago; Yale University; University of Wisconsin System; University of Wisconsin Stevens Point; University of Chicago
  摘要：Through the industrial era, pollutants have been unevenly distributed intheenvironment, disproportionatelyimpacting disenfranchised communities. Redressing the unequal distribution of environmental pollution is thus a question of environmental justice and public health that requires policy solutions. However, data on pollutants for many locations and time periods are limited because environmental monitoring is largely reactive-i.e., pollutants are monitored only after they are recognized as ha...
• Prospects for cereal self- sufficiency in sub- Saharan Africa AI翻译
  作者：van Ittersuma, Martin K.; Alimagham, Seyyedmajid; Silva, Joao Vasco; Adjei-Nsiah, Samuel; Baijukya, Frederick P.; Bala, Abdullahi; Chikowo, Regis; Grassini, Patricio; de Groot, Hugo L. E.; Nshizirungu, Aphrodis; Soule, Abdelkader Mahamane; Sulser, Timothy B.; Taulya, Godfrey; Tenorio, Fatima Amor; Tesfaye, Kindie; Yuan, Shen; van Loon, Marloes P.
  作者单位：Wageningen University & Research; Swedish University of Agricultural Sciences; University of Ghana; University of Zimbabwe; University of Nebraska System; University of Nebraska Lincoln; Wageningen University & Research; CGIAR; International Food Policy Research Institute (IFPRI); Makerere University; Huazhong Agricultural University
  摘要：Sub-Saharan Africa (SSA) has the world's largest projected increase in demand for food. Increased dependence on imports makes SSA vulnerable to geopolitical and economic risks, while further expansion of agricultural land is environmentally harmful. Cereals, in particular, maize, millet, rice, sorghum, and wheat, take nearly 50% of the cropland and 43% of the calories and proteins consumed in the region. Demand is projected to double until 2050. Here, we assess recent developments in cereal se...
• Global health and climate benefits from walking and cycling infrastructure AI翻译
  作者：Ball, Adam Millard -; Reginald, Monisha; Yusuf, Yasmina; Bian, Christopher
  作者单位：University of California System; University of California Los Angeles; Alphabet Inc.; Google Incorporated
  摘要：We use a globally consistent dataset-Google Environmental Insights Explorer-to quantify how urban form and transport infrastructure affect walking and cycling rates in 11,587 cities from 121 countries across six continents. At the city level, population density has the largest effect on walk mode share and has a positive impact on cycling too, as higher densities bring destinations within feasible walk and cycle distances. Density has the strongest effects in wealthier countries where traveler...