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作者：Hallers-Haalboom, Elizabeth T.; De Jaegher, Kris J. M.; Sterck, Elisabeth H. M.; Brosnan, Sarah F.; Vermande, Marjolijn M.
作者单位：Tilburg University; Utrecht University; Utrecht University; University System of Georgia; Georgia State University; University System of Georgia; Georgia State University; Utrecht University
摘要：Cooperation often requires individuals to balance personal risk with mutual gain. The Stag Hunt game provides a well- established paradigm for studying such decision- making. Prior research suggested that verbal communication about the game correlated with participants finding the optimal coordinated solution, but these studies either did not manipulate communication directly or informed participants of the payoff structure in advance. This study examined whether communication improves coopera...
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作者：Ma, Zhibo; Zhou, Xi; Jia, Wenlong; Tan, Xiaosheng; Huang, Xia; Wang, Jingzeng; Sun, Lingjuan; Li, Qingwen; Zhao, Xiangli; Yuan, Naonao; Liu, Ping; Liu, Jing; Chen, Zhishui; Lan, Peixiang
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作者：Tabatabaeian, Shadab; O'bi, Artemisia; Landy, David; Marghetis, Tyler
作者单位：University of California System; University of California Merced; Indiana University System; Indiana University Bloomington; Netflix, Inc.
摘要：The eureka insights that drive progress in science and mathematics remain shrouded in mystery. Sudden, unexpected, appearing like flashes of lightning, these insights have the hallmarks of critical transitions in complex systems. Here, zooming in on mathematicians working on proofs in their own departments, we show that sudden insights are anticipated by a system-agnostic, information-theoretic early warning signal. Using dense behavioral recordings of mathematicians' moment-to-moment activity...
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作者：Urda-Garciaa, Beatriz; Sanchez-Valle, Jon; Lepore, Rosalba; Valencia, Alfonso
作者单位：Universitat Politecnica de Catalunya; Barcelona Supercomputer Center (BSC-CNS); Pompeu Fabra University; University of Basel; University of Basel; ICREA
摘要：Epidemiological evidence shows that some diseases tend to co-occur; more exactly, certain groups of patients with a given disease are at a higher risk of developing a specific secondary condition. Here, we develop an approach to generate a disease network that uses the accumulating RNA-seq data on human diseases to significantly match an unprecedented proportion of known comorbidities, providing plausible biological models for such co-occurrences and effectively mirroring the underlying struct...
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作者：Regev, Johanna; Szanton, Nahshon; Vukosavovic, Filip; Berko, Itamar; Shalev, Yiftah; Uziel, Joe; Mintz, Eugenia; Regev, Lior; Boaretto, Elisabetta
作者单位：Weizmann Institute of Science
摘要：Using well-established microarchaeological sampling methods, we reached a precise radiocarbon date of 800 BC for the Siloam Pool's monumental water dam in Jerusalem. This date is a critical link connecting several imposing waterworks constructed at that time. Climate data pointing to droughts and flash floods during the last decades of the 9th century BC provide a logical framework for the reasons behind such endeavors. These included the fortification of the city's primary water source, the G...
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作者：Rigou, Sofia; Schmitt, Alain; Moreno, Anaisa B.; Lartigue, Audrey; Danner, Lucile; Mayer, Lotte; Giry, Claire; Trabelsi, Feres; Belmudes, Lucid; Olivero-Deibe, Natalia; Le Guenno, Hugo; Coute, Yohann; Berois, Mabel; Legendre, Matthieu; Jeudy, Sandra; Abergel, Chantal; Bisio, Hugo
作者单位：Aix-Marseille Universite; University of Vienna; Communaute Universite Grenoble Alpes; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); CEA; Universite Grenoble Alpes (UGA); Pasteur Network; Institut Pasteur de Montevideo; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Universidad de la Republica, Uruguay
摘要：Despite sharing fewer than 10 core genes, the hyperdiverse Nucleocytoviricota phylum (ranging from poxviruses to giant viruses) universally assembles viral factories (VFs) resembling biomolecular condensates. Regardless, it is unclear how these viruses achieve such a level of functional conservation without clear conserved genetic information. We demonstrate that the VFs produced by amoeba- infecting viruses have liquid- like properties and identify a conserved molecular grammar governing vira...
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作者：Walker, Sharon L.; Dagan, Gedeon; Adin, Avner; Alvarez, Pedro J. J.; Elimelech, Menachem; Radian, Adi
作者单位：Drexel University; Tel Aviv University; Hebrew University of Jerusalem; Rice University; Rice University; Technion Israel Institute of Technology
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作者：Yang, Guang; Du, Ximing; Norris, Dougall; Zadoorian, Armella; Zheng, Yuyuan; Gao, Mingming; Brown, Andrew J.; Grey, Shane T.; Zhou, Chun; Yang, Hongyuan
作者单位：University of New South Wales Sydney; Zhejiang University; Zhejiang University; University of Texas System; University of Texas Health Science Center Houston; George Institute for Global Health; University of New South Wales Sydney
摘要：The glycerol-3-phosphate (G-3-P) pathway is central to the synthesis of triacylglycerols (TAGs) and glycerophospholipids, essential for membrane biogenesis and lipid storage. The first and rate-limiting step in this pathway is catalyzed by glycerol-3-phosphate acyltransferases (GPATs), with microsomal GPAT3 and GPAT4 being evolutionarily conserved and predominant in most tissues. While previous studies have implicated Calcineurin B homologous protein 1 (CHP1) as a cofactor for GPAT4, the broad...
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作者：Jenne, Craig; Kubes, Paul
作者单位：University of Calgary; University of Calgary; Queens University - Canada
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作者：Luo, Jing; Chia, Natalie; Qin, Yuxi; Tan, Pan; Zhang, Lingwen; Yang, Sihan; Yuan, Zihan; Hong, Liang; Lee, Sang Yup; Tong, Yaojun
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Artificial Intelligence Laboratory; Shanghai Jiao Tong University; Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST)
摘要：Streptomyces are naturally endowed with the capacity to produce a wide array of natural products with biomedical and biotechnological value. They have garnered great interest in synthetic biology applications given the abundance of uncharacterized biosynthetic gene clusters (BGCs). However, progress has been hindered by the limited availability of genetic tools for manipulating these bacteria. Several representative CRISPR-Cas systems have been established in Streptomyces to streamline experim...
