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作者：Burns, Alon; Toker, Sharon; Berson, Yair; Gordon, Ilanit
作者单位：Bar Ilan University; Tel Aviv University; McMaster University; Bar Ilan University; Yale University
摘要：In a world where teams serve as the backbone of collaboration and innovation, women must feel safe when contributing to teamwork. Unfortunately, an increasing number of women report experiencing sexual harassment in workplaces and other collective settings. This research included an examination of how exposure to sexist insults affects collaborative efforts. We argue that in addition to its well- documented effects on individuals, sexism within teams undermines team performance. Hence, emotion...
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作者：Lenner, Nicolas; Chariker, Logan; Leibler, Stanislas
作者单位：Institute for Advanced Study - USA; Duke University; Rockefeller University
摘要：In the common cellular space, hundreds of binding reactions occur reliably and enable this remarkable compatibility have not yet been adequately elucidated. In order to delineate these principles, we consider the intracellular sensing of transition metals in bacteria-an integral part of cellular metal homeostasis. Protein cytosolic sensors typically interact with metals through three types of lateral chain residues, containing oxygen, nitrogen, or sulfur. The very existence of complete sets of...
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作者：Zhou, Yang; Sheng, Qiongyu; Jin, Shuilin
作者单位：Harbin Institute of Technology; Harbin Institute of Technology
摘要：Constructing single-cell atlases requires preserving differences attributable to biological variables, such as cell types, tissue origins, and disease states, while eliminating batch effects. However, existing methods are inadequate in explicitly modeling these biological variables. Here, we introduce SIGNAL, a general framework that leverages biological variables to disentangle biological and technical effects, thereby linking these metadata to data integration. SIGNAL employs a variant of pr...
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作者：Rose, Jeffrey P.; Li, Bing; Koehler, Margaret J. Sporck-; Stacy, Elizabeth A.; Wood, Kenneth R.; Lemmon, Emily Moriarty; Lemmon, Alan R.; Ane, Cecile; Sytsma, Kenneth J.; Givnish, Thomas J.
作者单位：University of Wisconsin System; University of Wisconsin Madison; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; State University System of Florida; Florida State University; State University System of Florida; Florida State University; University of Wisconsin System; University of Wisconsin Madison
摘要：Hawaiian lobeliads exhibit extensive adaptive radiations and are considered the largest plant clade (143 species) endemic to any oceanic archipelago. Rapid insular radiations are prone to reticulate evolution, yet detecting hybridization is often limited by inadequate sampling of taxa or independent loci. We analyzed 633 nuclear loci (including tetraploid duplications) and whole plastomes for 89% of extant species to derive phylogenies for the Hawaiian lobeliads. Nuclear data provide strong su...
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作者：Gomez, Ignacio Lopez; Wan, Zhong Yi; Zepeda-Nunez, Leonardo; Schneider, Tapio; Anderson, John; Sha, Fei
作者单位：Alphabet Inc.; Google Incorporated; California Institute of Technology
摘要：Regional high-resolution climate projections are crucial for many applications, such as agriculture, hydrology, and natural hazard risk assessment. Dynamical downscaling, the state-of-the-art method to produce localized future climate information, involves running a regional climate model (RCM) driven by an Earth System Model (ESM), but it is too computationally expensive to apply to large climate projection ensembles. We propose an approach combining dynamical downscaling with generative AI t...
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作者：Veenbaas, Seth D.; Koehn, Jordan T.; Irving, Patrick S.; Lama, Nicole N.; Weeks, Kevin M.
作者单位：University of North Carolina; University of North Carolina Chapel Hill
摘要：RNAs are critical regulators of gene expression, and their functions are often mediated by complex secondary and tertiary structures. Structured regions in RNA can selectively interact with small molecules-via well-defined ligandbinding pockets-to modulate the regulatory repertoire of an RNA. The broad potential to modulate biological function intentionally via RNA-ligand interactions remains unrealized, however, due to challenges in identifying compact RNA motifs with the ability to bind liga...
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作者：Wang, Jia-nan; Suo, Xiao-guo; Yu, Ju-tao; Luo, Qi-chao; Ji, Ming-lu; Zhang, Meng-meng; Zhu, Qi; Cheng, Xin-ran; Hou, Chao; Chen, Xin; Wang, Fang; Xu, Chuan-hui; Li, Chao; Xie, Shuai-shuai; Wei, Jie; Zhang, Dan-feng; Zhang, Xin-ru; Wang, Zhi-juan; Dong, Yu- hang; Zhu, Sai; Peng, Li-jin; Li, Xiang-yu; Chen, Hai-yong; Xu, Tao; Jin, Juan; Chen, Fei Xavier; Meng, Xiao-ming
作者单位：Anhui Medical University; Anhui Medical University; Anhui Medical University; Anhui Medical University; University of Hong Kong; University of Hong Kong; Fudan University
摘要：Inflammation plays an essential role in eliminating microbial pathogens and repairing tissues, while sustained inflammation accelerates kidney damage and disease progression. Therefore, understanding the mechanisms of the inflammatory response is vital for developing therapies for inflammatory kidney diseases like acute kidney injury (AKI), which currently lacks effective treatment. Here, we identified N-acetyltransferase 10 (NAT10) as an important regulator for acute inflammation. NAT10, the ...
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作者：Charlesworth, Deborah
作者单位：University of Edinburgh
摘要：As in many diploid organisms with genetic sex determination, haploid-dominant organisms have also evolved sex chromosomes or extensive genomic regions that lack genetic recombination. An understanding of sex chromosome evolution should explain the causes and consequences of such regions in both diploids and haploids. However, haploids have been little studied, even though differences from sex chromosomes in diploids carry implications concerning the evolution of suppressed recombination in dip...
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作者：Lugassy, Jennie; Saleh, Noor Abdala -; Jarrous, Ghada; Turky, Abeer; Saidemberg, Daniel; Bahar, Gabriela Ridner -; Berger, Nir; On, Dana Bar -; Taura, Tetsuya; Wilson, David; Karin, Nathan; Steinman, Lawrence
作者单位：Technion Israel Institute of Technology; Teva Pharmaceutical Industries; Teva Pharmaceutical Industries; Teva Pharmaceutical Industries USA
摘要：CXCR3 is a chemokine receptor for three ligands: CXCL9, CXCL10, and CXCL11. Accumulating evidence, including data presented here, suggests that the interaction between CXCL9/CXCL10 and CXCR3 not only attracts CXCR3+ T cells but also cell killing. One of the homeostatic mechanisms that may limit this cycle is the cleavage of the two N- terminal amino acids of these chemokines by Dipeptidyl Peptidase IV (DPP- 4). The modified chemokines retain their ability to bind CXCR3 but no longer activate i...
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作者：Willis, Leon F.; Brockwell, David J.; Radford, Sheena E.
作者单位：University of Leeds
