2025

最新文章

• Biophysical modeling of membrane curvature generation and curvature sensing by the glycocalyx AI翻译
  作者：Xiao, Ke; Park, Sujeong; Stachowiak, Jeanne C.; Rangamani, Padmini
  作者单位：University of California System; University of California San Diego; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of California System; University of California San Diego
  摘要：Generation of membrane curvature is fundamental to cellular function. Recent studies have established that the glycocalyx, a sugar-rich polymer layer at the cell surface, can generate membrane curvature. While there have been some theoretical efforts to understand the interplay between the glycocalyx and membrane bending, there remain open questions about how the properties of the glycocalyx affect membrane bending. For example, the relationship between membrane curvature and the density of gl...
• Superfluid weight cross-over and critical temperature enhancement in singular flat bands AI翻译
  作者：Jiang, Guodong; Torma, Paivi; Barlas, Yafis
  作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; Aalto University
  摘要：Nonanalytic Bloch eigenstates at isolated band degeneracy points exhibit singular behavior in the quantum metric. Here, a description of superfluid weight for zero- energy flat bands in proximity to other high-energy bands is presented, where they together form a singular band gap system. When the singular band gap closes, the geometric and conventional contributions to the superfluid weight as a function of the superconducting gap exhibit different cross-over behaviors. The scaling behavior o...
• Downscaling mutualistic networks from species to individuals reveals consistent interaction niches and roles within plant populations AI翻译
  作者：Quintero, Elena; Arroyo-Correa, Blanca; Isla, Jorge; Rodriguez-Sanchez, Francisco; Jordano, Pedro
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); University of Sevilla
  摘要：Species- level networks emerge as the combination of interactions spanning multiple individuals, and their study has received considerable attention over the past 30 y. However, less is known about the structure of interaction configurations within species, even though individuals are the actual interacting units in nature. We compiled 46 empirical, individual- based, interaction networks on plant- animal seed dispersal mutualisms, comprising 1,037 plant individuals across 29 species from vari...
• Liver- specific transgenic expression of human NTCP in rhesus macaques confers HBV susceptibility on primary hepatocytes AI翻译
  作者：Rust, Lauren N.; Wettengel, Jochen M.; Ryu, Junghyun; Piekarski, Nadine; Yusova, Sofiya; Lutz, Savannah S.; Naldiga, Spandana; Hinrichs, Brayden J.; Sullivan, Michelle N.; Lo, Jamie O.; Protzer, Ulrike; V. Smedley, Jeremy; Sacha, Jonah B.; Hanna, Carol B.; Bimber, Benjamin N.; Hennebold, Jon D.; Burwitz, Benjamin J.
  作者单位：Oregon Health & Science University; Oregon National Primate Research Center; German Center for Infection Research; Oregon Health & Science University; Oregon National Primate Research Center; Oregon Health & Science University; Oregon National Primate Research Center; Oregon Health & Science University; Oregon National Primate Research Center; Oregon Health & Science University; Oregon National Primate Research Center
  摘要：Hepatitis B virus (HBV) poses a significant global health challenge, necessitating the urgent development of curative therapeutics. However, this progress is impeded by the lack of robust, immunocompetent preclinical animal models due to HBV's strict species specificity. We previously showed that vector- mediated expression of the HBV entry receptor, fully susceptible to HBV infection. In this study, we have generated transgenic macaques expressing hNTCP, marking the creation of the first tran...
• Reply to Chen et al.: Coarse simulations overestimate the distance to recover NO-NO2-O3 photochemical steady state in fresh NOx plumes AI翻译
  作者：Varon, Daniel J.; Jervis, Dylan; Pandey, Sudhanshu; Gallardo, Sebastian L.; Balasus, Nicholas; Yang, Laura Hyesung; Jacob, Daniel J.
  作者单位：Harvard University; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); Comision Nacional de Energia Atomica (CNEA); Centro Atomico Bariloche
• Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu AI翻译
  作者：Boulouis, Caroline; Mouchtaridi, Elli; Muller, Thomas R.; Mak, Jeffrey Y. W.; Fairlie, David P.; Bergman, Peter; Michaelsson, Jakob; Halfvarson, Jonas; Mjosberg, Jenny; Buggert, Marcus; Sandberg, Johan K.
  作者单位：Karolinska Institutet; University of Queensland; Karolinska Institutet; Karolinska Institutet; Karolinska University Hospital; Orebro University; Karolinska Institutet; Karolinska University Hospital
  摘要：Mucosal- associated invariant T (MAIT) cells are unconventional T cells that mediate rapid antimicrobial immune responses to antigens derived from microbial riboflavin pathway metabolites presented by the evolutionarily conserved MR1 molecules. MAIT cells represent a large pre- expanded T cell subset in humans and are involved in both protective immunity and inflammatory immunopathology. However, what controls the functional heterogeneity of human MAIT cell responses is still largely unclear. ...
• Correction for Knight and Zhang, Residential mobility and persistently depressed voting among disadvantaged adults in a large housing experiment (vol 121, e2306287121, 2024) AI翻译
  作者：Knight, David Jonathan; Zhang, Baobao
• Evidence for domain-general arousal from semantic and neuroimaging meta-analyses reconciles opposing views on arousal AI翻译
  作者：Sabat, Magdalena; de Dampierre, Charles; Tallon-Baudry, Catherine
  作者单位：Universite PSL; Ecole Normale Superieure (ENS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Normale Superieure (ENS); Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS)
  摘要：Arousal refers to changes in brain- body state underpinning motivated behavior but lacks a proper definition and taxonomy. Neuroscience and psychology textbooks offer surprisingly different views on what arousal is, from a global brain-wide modulation of neuronal activity to a multidimensional construct, with specific brain-body patterns tuned to a given situation. The huge number of scientific articles mentioning arousal (similar to 50,000) highlights the importance of the concept but also ex...
• Functional SARS- CoV- 2 cross- reactive CD4+ T cells established in early childhood decline with age (vol 120, e2220320120, 2023) AI翻译
  作者：Humbert, Marion; Olofsson, Anna; Wullimann, David; Niessl, Julia; Hodcroft, Emma B.; Cai, Curtis; Gao, Yu; Sohlberg, Ebba; Dyrdak, Robert; Mikaeloff, Flora; Neogi, Ujjwal; Albert, Jan; Malmberg, Karl-Johan; Lund-Johansen, Fridtjof; Aleman, Soo; Bjoerkhem-Bergman, Linda; Jenmalm, Maria C.; Ljunggren, Hans-Gustaf; Buggert, Marcus; Karlsson, Annika C.
• Fatty acid metabolism and the oxidative stress response support bacterial predation AI翻译
  作者：Jain, Rikesh; Le, Nguyen - Hung; Bertaux, Lionel; Baudry, Jean; Bibette, Jerome; Denis, Yann; Habermann, Bianca H.; Mignot, Tam
  作者单位：Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Aix-Marseille Universite
  摘要：Despite growing awareness of their importance in soil ecology, the genetic and physiological traits of bacterial predators are still relatively poorly understood. In the course of a Myxococcus xanthus predator evolution experiment, we identified a class of genotypes leading to enhanced predation against diverse species. RNA- seq analysis demonstrated that this phenotype is linked to the constitutive activation of a predation- specific program. Functional analysis of the mutations accumulated a...