2025

最新文章

• Automating the practice of science: Opportunities, challenges, and implications AI翻译
  作者：Musslick, Sebastian; Bartlett, Laura K.; Chandramouli, Suyog H.; Dubova, Marina; Gobet, Fernand; Griffiths, Thomas L.; Hullman, Jessica; King, Ross D.; Kutz, J. Nathan; Lucas, Christopher G.; Mahesh, Suhas; Pestilli, Franco; Sloman, Sabina J.; Holmes, William R.
  作者单位：University Osnabruck; Brown University; University of London; London School Economics & Political Science; Aalto University; University of Alberta; Princeton University; Indiana University System; Indiana University Bloomington; Roehampton University; Princeton University; Northwestern University; University of Cambridge; Chalmers University of Technology; University of Washington; University of Washington Seattle; University of Edinburgh; University of Toronto; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Manchester
  摘要：Automation transformed various aspects of our human civilization, revolutionizing industries and streamlining processes. In the domain of scientific inquiry, automated approaches emerged as powerful tools, holding promise for accelerating discovery, enhancing reproducibility, and overcoming the traditional impediments to scientific progress. This article evaluates the scope of automation within scientific practice and assesses recent approaches. Furthermore, it discusses different perspectives...
• NR2B subunit of the NMDA glutamate receptor regulates appetite in the parabrachial nucleus (vol 110, pg 14765, 2013) AI翻译
  作者：Wu, Qi; Zheng, Ruimao; Srisai, Dollada; McKnight, G. Stanley; Palmiter, Richard D.
• Tree rings and Earth System Models unveil mid- Holocene alpine climate AI翻译
  作者：Bunn, Andrew G.
  作者单位：Western Washington University
• Co- option of mitochondrial nucleic acid-sensing pathways by HSV-1 UL12.5 for reactivation from latent infection AI翻译
  作者：Krakowiak, Patryk A.; Flores, Matthew E.; Cuddy, Sean R.; Whitford, Abigail L.; Dochnal, Sara A.; Babnis, Aleksandra; Miyake, Tsuyoshi; Tigano, Marco; Engel, Daniel A.; Cliffe, Anna R.
  作者单位：University of Virginia; University of Virginia; Thomas Jefferson University; University of California System; University of California San Diego
  摘要：Although viruses subvert innate immune pathways for their replication, there is evidence they can also co- opt antiviral responses for their benefit. The ubiquitous human pathogen, Herpes simplex virus- 1 (HSV- 1), encodes a protein (UL12.5) that induces the release of mitochondrial nucleic acid into the cytosol, which activates immune- sensing pathways and reduces productive replication in nonneuronal cells. HSV- 1 establishes latency in neurons and can reactivate to cause disease. We found t...
• Advancing forecasting capabilities: A contrastive learning model for forecasting tropical cyclone rapid intensification AI翻译
  作者：Wang, Chong; Yang, Nan; Li, Xiaofeng
  作者单位：Chinese Academy of Sciences; Institute of Oceanology, CAS; Chinese Academy of Sciences; Institute of Oceanology, CAS
  摘要：Tropical cyclones (TCs), particularly those that rapidly intensify (RI), pose a significant threat due to the uncertainty in forecasting them. RI TC periods, which intensify by at least 13 m/s within 24 h, remain challenging to forecast accurately. Existing models achieve a probability of detection (POD) of 82.6% and a false alarm rate (FARate) of 27.2%. To address this, we developed a contrastive- based RI TC forecasting (RITCF- contrastive) model, utilizing satellite infrared imagery alongsi...
• Epstein-Barr virus BALF0/1 subverts the Caveolin and ERAD pathways to target B cell receptor complexes for degradation AI翻译
  作者：Yiu, Stephanie Pei Tung; Liao, Yifei; Yan, Jinjie; Weekes, Michael P.; Gewurz, Benjamin E.
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; University of Cambridge
  摘要：Epstein-Barr virus (EBV) establishes persistent infection, causes infectious mononucleosis, is a major trigger for multiple sclerosis and contributes to multiple cancers. Yet, knowledge remains incomplete about how the virus remodels host B cells to support lytic replication. We previously identified that EBV lytic replication results in selective depletion of plasma membrane (PM) B cell receptor (BCR) complexes, composed of immunoglobulin and the CD79A and CD79B signaling chains. Here, we use...
• Floodplain forests drive fruit- eating fish diversity at the Amazon Basin-scale AI翻译
  作者：[Anonymous]
  摘要：Unlike most rivers globally, nearly all lowland Amazonian rivers have unregulated flow, supporting seasonally flooded floodplain forests. Floodplain forests harbor a unique tree species assemblage adapted to flooding and specialized fauna, including fruit-eating fish that migrate seasonally into floodplains, favoring expansive floodplain areas. Frugivorous fish are forest-dependent fauna critical to forest regeneration via seed dispersal and support commercial and artisanal fisheries. We imple...
• Splenic filtration of red blood cells: Physics, chemistry, and biology need to go hand in hand AI翻译
  作者：Kaestner, Lars; Egee, Stephane; Connes, Philippe; Bogdanova, Anna Yu.; Simmonds, Michael J.
  作者单位：Universitatsklinikum des Saarlandes; Saarland University; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Sorbonne Universite; Universite Claude Bernard Lyon 1; University of Zurich; Griffith University; Griffith University - Gold Coast Campus
• A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia AI翻译
  作者：Dong, Zhen; Sepulveda, Hugo; Arteaga-Vazquez, Leo J.; Blouin, Chad; Fernandez, Jenna; Binder, Moritz; Chou, Wen-Chien; Tien, Hwei-Fang; Patnaik, Mrinal M.; Faulkner, Geoffrey J.; Myers, Samuel A.; Rao, Anjana
  作者单位：La Jolla Institute for Immunology; University of California System; University of California San Diego; Universidad Andres Bello; Universidad Andres Bello; Mayo Clinic; National Taiwan University; National Taiwan University Hospital; University of Queensland; Mater Research; University of Queensland
  摘要：ASXL transcriptional regulator 1 (ASXL1) is one of the three most frequently mutated genes in age- related clonal hematopoiesis (CH), alongside DNA methyltransferase 3 alpha (DNMT3A) and Tet methylcytosine dioxygenase 2 ( TET2) . CH can progress to myeloid malignancies including chronic monomyelocytic leukemia (CMML) and is also strongly associated with inflammatory cardiovascular disease and all- cause mortality in humans. DNMT3A and TET2 regulate DNA methylation and demethylation pathways, r...
• Unveiling hidden reaction kinetics of carbon dioxide in supercritical aqueous solutions AI翻译
  作者：Li, Chu; Yao, Yuan; Pan, Ding
  作者单位：Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology
  摘要：Dissolution of CO2 in water followed by the subsequent hydrolysis reactions is of great importance to the global carbon cycle, and carbon capture and storage. Despite numerous previous studies, the reactions are still not fully understood at the atomistic scale. Here, we combined ab initio molecular dynamics (AIMD) simulations with Markov state models to elucidate the reaction mechanisms and kinetics of CO2 in supercritical water both in the bulk and nanoconfined states. The integration of uns...