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作者：Boulton, Kelsie A.; Guastella, Adam J.
作者单位：University of Sydney; NSW Health; Sydney Childrens Hospitals Network; University of Sydney
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作者：Calixto, Camilo; Soldatelli, Matheus Dorigatti; Jaimes, Camilo; Pierotich, Lana; Warfield, Simon K.; Gholipour, Ali; Karimi, Davood
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of California System; University of California Irvine
摘要：This study presents the construction of a comprehensive spatiotemporal atlas of white matter tracts in the fetal brain for every gestational week between 23 and 36 wk using diffusion MRI (dMRI). Our research leverages data collected from fetal MRI scans, capturing the dynamic changes in the brain's architecture and microstructure during this critical period. The atlas includes 60 distinct white matter tracts, including commissural, projection, and association fibers. We employed advanced fetal...
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作者：Jimenez-Rondan, Felix R.; Ruggiero, Courtney H.; Riva, Alberto; Yu, Fahong; Stafford, Lauren S.; Cross, Tyler R.; Larkin III, Joseph; Cousins, Robert J.
作者单位：State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida
摘要：by J. accepted by Documented worldwide, impaired immunity is a cardinal signature resulting from loss of dietary zinc, an essential micronutrient. A steady supply of zinc to meet cellular requirements is regulated by an array of zinc transporters. Deletion of the transporter Zip14 (Slc39a14) in mice produced intestinal inflammation. Elevated fecal lipocalin-2, calprotectin, IgG levels, and dysbiosis support the inflammatory phenotype. Here, we show through RNA-sequencing, using purified intest...
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作者：Lemaitre, Jean-Francois; Voituron, Yann; Herpe, Lea; Veyrunes, Frederic
作者单位：Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); VetAgro Sup; Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; CNRS - Institute of Ecology & Environment (INEE); University of Moncton; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier
摘要：A wave of studies has recently emphasized the influence of sex chromosomes on both lifespan and actuarial senescence patterns across vertebrates and invertebrates. Basically, the heterogametic sex (XY males in XX/XY systems or ZW females in ZW/ZZ systems) typically displays a lower lifespan and a steeper rate of actuarial senescence than the homogametic sex. However, whether these effects extend to the senescence patterns of other phenotypic traits or physiological functions is yet to be deter...
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作者：Millholland, Sarah C.; Winn, Joshua N.
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Princeton University
摘要：Although nearly 6,000 exoplanets are currently known, in most cases, our knowledge is limited to a handful of the planet's orbital characteristics and bulk properties such as radius and mass. The James Webb Space Telescope (JWST) can expand our knowledge not only by probing exoplanet atmospheres but also by measuring additional orbital and physical properties of exoplanets, thanks to its superior light-gathering power and measurement precision. Here, we describe the potential of JWST to unveil...
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作者：Ren, Xiaokang; Song, Xiaowei; Lyu, Lecheng; Chen, Michael W.; Zare, Richard N.; Dai, Yifan
作者单位：Washington University (WUSTL); Stanford University; Washington University (WUSTL)
摘要：Compartmentalization and chemical reactivity serve as the key elements driving prebiotic chemistry for evolution and selection. However, the potential coupling of compartmentalization chemistry with the intrinsic chemical activity of prebiotic compartments remains largely unexplored. Here, we demonstrate that anion-1t interactions, which are largely overlooked in the chemistry of phase transition, can drive the formation of micron-sized assemblies. These structures further recruit cations to f...
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作者：Wang, Chuanxi; Cheng, Bingxu; Xiao, Zhenggao; Ji, Yahui; Zhang, Jiangshan; Zhou, Rongxin; Yuan, Xian - Zheng; Kah, Melanie; Wang, Zhenyu; Xing, Baoshan
作者单位：Jiangnan University; Jiangnan University; Shandong University; University of Auckland; University of Massachusetts System; University of Massachusetts Amherst
摘要：Enhancing nitrogen use efficiency (NUE) in agricultural production can reduce fertilizer input, mitigate greenhouse gas emissions and decrease water pollution incidence. However, improving NUE in farming systems without compromising food security remains challenging. Herein, we have successfully developed and applied selenium-based nanotechnology, which capitalizes on above-and belowground synergies to enhance field-scale NUE. Specifically, when N fertilizer application was reduced by 30%, fol...
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作者：Young-Brun, Marie; Dennig, Francis; Errickson, Frank; Feindt, Simon; Mejean, Aurelie; Zuber, Stephane
作者单位：Centre National de la Recherche Scientifique (CNRS); Paris School of Economics; Leibniz Association; Leibniz Institut fur Wirtschaftsforschung Halle (IWH); Leipzig University; The World Bank; Princeton University; Potsdam Institut fur Klimafolgenforschung; Technical University of Berlin; Centre National de la Recherche Scientifique (CNRS); AgroParisTech
摘要：Climate policy design must balance emissions mitigation with concerns for fairness, particularly as climate change disproportionately affects the poorest households within and across countries. Integrated Assessment Models used for global climate policy evaluation have so far typically not considered inequality effects within countries. To fill this gap, we develop a global Integrated Assessment Model representing national economies and subnational income, mitigation cost, and climate damage d...
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作者：Kamp, Leon M.; Zanaty, Mohamed; Zareei, Ahmad; Gorissen, Benjamin; Wood, Robert J.; Bertoldi, Katia
作者单位：Harvard University; KU Leuven
摘要：Programming physical intelligence into mechanisms holds great promise for machines that can accomplish tasks such as navigation of unstructured environments while utilizing a minimal amount of computational resources and electronic components. In this study, we introduce a design approach for physically intelligent underactuated mechanisms capable of autonomously adjusting their motion in response to environmental interactions. Specifically, multistability is harnessed to sequence the motion o...
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作者：Li, Jinxi; Xiang, Ting; Zhang, Fengping; Feng, Li; Wu, Yiting; Guo, Fan; Li, Lingzhi; Fu, Ping; Ma, Liang
作者单位：Sichuan University
摘要：Kidney fibrosis is driven by multiple factors, among which impaired fatty acid oxidation has emerged as a critical determinant. Acyl-Coenzyme A (CoA) synthetase medium-chain family member 3 (ACSM3), a key enzyme of medium-chain fatty acid (MCFA) metabolism, has been implicated in metabolic syndrome, but its function in fibrotic kidney remains unexplored. Here, we found that tubular epithelial ACSM3 expression was downregulated in kidney fibrotic mice and patients and inversely correlated with ...
