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作者：Yoshida, Aiko; Uekusa, Yoshitsugu; Suzuki, Takeshi; Bauer, Michael; Sakai, Nobuaki; Yamauchi, Yohei
作者单位：Novo Nordisk; Hokkaido University; Olympus Corporation; Nagoya University; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; University of West England; University of Bristol
摘要：Influenza A virus (IAV) entry into host cells begins with interactions between the viral envelope proteins hemagglutinin (HA)/neuraminidase (NA) and sialic acid moieties on the cell plasma membrane. These interactions drive IAV's lateral diffusion along the cell membrane and trigger membrane morphological changes required for endocytosis. However, directly visualizing these dynamic processes, which are crucial for IAV entry, has been challenging using conventional microscopy techniques. In thi...
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作者：Pizzamiglio, Lara; Morice, Elise; Cardoso, Cecile; Bossi, Simon; Mailhes-Hamon, Caroline; von Heimendahl, Moritz; Girardeau, Gabrielle; Paoletti, Pierre
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite
摘要：Excitatory glycine receptors (eGlyRs), composed of the glycine-binding NMDA receptor subunits GluN1 and GluN3A, have recently emerged as a novel neuronal signaling modality that challenges the traditional view of glycine as an inhibitory neurotransmitter. Unlike conventional GluN1/GluN2 NMDARs, the distribution and role of eGlyRs remain poorly understood. Here, we show that eGlyRs are highly enriched in the ventral hippocampus (VH) and confer distinct properties on this brain region. eGlyRs di...
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作者：Vosshall, Leslie B.
作者单位：Howard Hughes Medical Institute; Rockefeller University; Rockefeller University
摘要：Scientists can contribute to society in numerous ways. Some scientists discover new biological principles and found entirely new fields. Some scientists are inspiring mentors and create the next generation of inclusive lab leaders. Some scientists are entrepreneurs who develop clinically effective therapeutics. Some scientists are trusted advisors to government and pharmaceutical companies. Some scientists are visionary institutional leaders who build new departments. From this menu of activit...
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作者：Adelmann, Charles H.; Venkatachalam, Avanthika; Huang, Lingjuan; Liu, Michelle; Germana, Sharon; Harry, Stefan A.; Rosen, Paul C.; Herron, Joshua; Tien, Pei- Chieh; Bar-Peled, Liron; Sabatini, David M.; Fisher, David E.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences
摘要：While it has been appreciated for decades that lysosomes can import cysteine, its significance for whole- organism physiology has remained uncertain. Recent work identified MFSD12 as a transmembrane protein required for cysteine import into lysosomes (and melanosomes), enabling genetic interrogation of this pathway. Here, we show that Mfsd12 knockout mice die between embryonic days 10.5 and 12.5, indicating that MFSD12 is essential for organogenesis. Mfsd12 loss results in the expression of ge...
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作者：Rowntree, Louise C.; Allen, Lilith F.; Hagen, Ruth R.; McQuilten, Hayley A.; Quadeer, Ahmed A.; Chaurasia, Priyanka; Kaewpreedee, Prathanporn; Lee, Kelly W. K.; Cohen, Carolyn A.; Petersen, Jan; Littler, Dene R.; Habel, Jennifer R.; Zhang, Wuji; Cheng, Samuel M. S.; Chan, Ken Ka Pang; Kwok, Janette S. Y.; Leung, Kathy S. M.; Wu, Joseph T.; Lee, Cheuk-Kwong; Davies, Jane; Pannaraj, Pia S.; Allen, E. Kaity; Thomas, Paul G.; Tosif, Shidan; Crawford, Nigel W.; Lappas, Martha; Thevarajan, Irani; Lewin, Sharon R.; Kent, Stephen J.; Juno, Jennifer A.; Bond, Katherine A.; Williamson, Deborah A.; Holmes, Natasha E.; Smibert, Olivia C.; Gordon, Claire L.; Trubiano, Jason A.; Kotsimbos, Tom C.; Cheng, Allen C.; Efstathiou, Claudia; Turtle, Lance; Thwaites, Ryan S.; Brightling, Christopher E.; Rossjohn, Jamie; McKay, Matthew R.; Tian, Jinmin; Liu, William Jun; Gao, George Fu; Xu, Jianqing; Sonehara, Kyuto; Ishii, Ken J.; Namkoong, Ho; Okada, Yukinori; Peiris, Malik; Hui, David S. C.; Poon, Leo L. M.; Doherty, Peter C.; Nguyen, Thi H. O.; Valkenburg, Sophie A.; Kedzierska, Katherine
作者单位：University of Melbourne; Peter Doherty Institute; Hong Kong University of Science & Technology; University of Melbourne; Monash University; Monash University; University of Hong Kong; University of Hong Kong; Chinese University of Hong Kong; Prince of Wales Hospital; Chinese University of Hong Kong; University of Hong Kong; University of Hong Kong; University of Hong Kong; Charles Darwin University; Menzies School of Health Research; Children's Hospital Los Angeles; University of California System; University of California Los Angeles; St Jude Children's Research Hospital; Murdoch Children's Research Institute; University of Melbourne; Royal Children's Hospital Melbourne; Royal Children's Hospital Melbourne; University of Melbourne; University of Melbourne; Peter Doherty Institute; University of Melbourne; Peter Doherty Institute; Melbourne Health; Royal Melbourne Hospital; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Monash University; University of Melbourne; Alfred Health; Melbourne Sexual Health Centre; Monash University; Victorian Infectious Diseases Reference Laboratory; University of Melbourne; Peter Doherty Institute; Melbourne Health; Royal Melbourne Hospital; University of St Andrews; Austin Research Institute; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Austin Research Institute; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; University of Melbourne; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Austin Research Institute; Peter Maccallum Cancer Center; Peter Maccallum Cancer Center; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Monash University; Monash University; Monash Health; Monash University; Monash University; Imperial College London; University of Liverpool; University of Leicester; Cardiff University; Chinese Center for Disease Control & Prevention; National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control & Prevention; Fudan University; Fudan University; University of Osaka; University of Tokyo; University of Tokyo; University of Osaka; Keio University; RIKEN; University of Osaka; Hokkaido University
摘要：Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in nonhospitalized individuals of European ancestry, with protective immunity attributed to preexisting cross-reactive CD8(+) T-cells directed against HLA-B*15:01-restricted Spike-derived S919-927 peptide (B15/S(919)(+)CD8(+) T-cells). However, fundamental questi...
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作者：Yao, Ze-Fan; Lim, Sujeung; Kuang, Yuyao; Lundqvist, Emil M.; Celt, Natalie; Chung, Caleb O.; Lee, Kathryn K.; Nguyen, Krystal; Le, Lanie; Tang, Sheng Wei; Milligan, Griffin M.; Kohl, Phillip; Sudarshan, Tarunya Rao; Li, Youli; Eguchi, Asuka; Paravastu, Anant K.; Zaragoza, Michael V.; Fishman, Dmitry A.; Ardona, Herdeline Ann M.
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Santa Barbara; University System of Georgia; Georgia Institute of Technology; University of California System; University of California Irvine; University of California System; University of California Irvine; University System of Georgia; Georgia Institute of Technology
摘要：Charge and energy transport within living systems are fundamental processes that enable the autonomous function of excitable cells and tissues. To date, localized control of these transport processes has been enabled by genetic modification approaches to render light sensitivity to cells. Here, we present peptidic nanoassemblies as constituents of a cardiac biomaterial platform that leverages complementary sequence interactions to direct photoinduced energy transport at the cellular interface....
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作者：Aprili, Cecile; Coupier, Gwennou; Lorenceau, Elise; Dollet, Benjamin
作者单位：Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
摘要：Aqueous foams are solid materials composed of gases and liquids, exhibiting a large gas/liquid surface area and enabling dynamic exchanges between their fluid components. The structure of binary-gas foams, whose bubbles consist of a mixture of two gases having different affinities with the liquid, thus offers real potential for the dynamic separation of these gases at low cost. In single-gas foams, the structure evolves under the effect of gas flow induced by Laplace pressure differences, aris...
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作者：Faught, Erin; Schaaf, Marcel J. M.
作者单位：Leiden University - Excl LUMC; Leiden University; Radboud University Nijmegen
摘要：It is well established that stress generally suppresses immunity. However, under certain conditions, acute stress has been shown to stimulate the immune system, particularly those at barrier surfaces like the skin. The cellular and molecular mechanisms underlying this effect remain poorly understood. In the present study, we have identified an immune-enhancing effect of stress using zebrafish larvae. The use of this animal model allowed us to visualize the redistribution of macrophages to the ...
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作者：Gou, Jiaojiao; Miao, Chiyuan; Ni, Jinren; Sorooshian, Soroosh; Duan, Qingyun; Yan, Denghua; Slater, Louise; Xu, Zongxue; Borthwick, Alistair G. L.; Su, Lu; Zhang, Qi; Wada, Yoshihide
作者单位：Beijing Normal University; Beijing Normal University; Peking University; University of California System; University of California Irvine; Hohai University; China Institute of Water Resources & Hydropower Research; University of Oxford; Beijing Normal University; University of Edinburgh; University of Plymouth; University of California System; University of California Los Angeles; King Abdullah University of Science & Technology
摘要：River flow connectivity, the continuity of fluvial discharge in space and time, provides a crucial lifeline for most biotic communities on Earth. Yet there is still limited understanding of the impacts of climate change and human water withdrawal on river connectivity. Here, we assess the river flow connectivity of 217,001 river reaches in mainland China from 1961 to 2020 and the impact of different climate warming trends and water withdrawals for different sectors. We estimate that naturally ...
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作者：Hart, William S.; Hurrell, James W.; Kaye, Alexander R.; Chand, Meera; Keeling, Matt J.; Thompson, Robin N.
作者单位：University of Oxford; Colorado State University System; Colorado State University Fort Collins; University of Warwick; University of Warwick; UK Health Security Agency (UKHSA)
摘要：In locations that do not currently experience vector-borne disease (VBD) outbreaks but may be at risk under climate change, modeling future climate suitability for transmission is important for outbreak preparedness. Uncertainty in the future climate arises from three sources-differences in emissions scenarios, structural uncertainty across climate models, and internal climate variability (ICV)-but ICV is rarely considered in climate-VBD studies. Here, we demonstrate that ICV is a key source o...
