Delocalized, asynchronous, closed-loop discovery of organic laser emitters

• 成果类型: Article
• 署名作者: Strieth-Kalthoff, Felix; Hao, Han; Rathore, Vandana; Derasp, Joshua; Gaudin, Theophile; Angello, Nicholas H.; Seifrid, Martin; Trushina, Ekaterina; Guy, Mason; Liu, Junliang; Tang, Xun; Mamada, Masashi; Wang, Wesley; Tsagaantsooj, Tuul; Lavigne, Cyrille; Pollice, Robert; Wu, Tony C.; Hotta, Kazuhiro; Bodo, Leticia; Li, Shangyu; Haddadnia, Mohammad; Wolos, Agnieszka; Roszak, Rafal; Ser, Cher Tian; Bozal-Ginesta, Carlota; Hickman, Riley J.; Vestfrid, Jenya; Aguilar-Granda, Andres; Klimareva, Elena L.; Sigerson, Ralph C.; Hou, Wenduan; Gahler, Daniel; Lach, Slawomir; Warzybok, Adrian; Borodin, Oleg; Rohrbach, Simon; Sanchez-Lengeling, Benjamin; Adachi, Chihaya; Grzybowski, Bartosz A.; Cronin, Leroy; Hein, Jason E.; Burke, Martin D.; Aspuru-Guzik, Alan
• 署名单位: University of Toronto; University of Toronto; University of Toronto; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of British Columbia; University of Illinois System; University of Illinois Urbana-Champaign; North Carolina State University; University of Glasgow; Kyushu University; Mitsubishi International Corporation (MIC); Mitsubishi Chemical Holdings Corporation; Mitsubishi Chemical; Vector Institute for Artificial Intelligence; Polish Academy of Sciences; Institute of Organic Chemistry of the Polish Academy of Sciences; Institut de Recerca en Energia de Catalunya (IREC); Jagiellonian University; Alphabet Inc.; Google Incorporated; Institute for Basic Science - Korea (IBS); Ulsan National Institute of Science & Technology (UNIST); University of Bergen; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Toronto; University of Toronto; Canadian Institute for Advanced Research (CIFAR)
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8157
• DOI: 10.1126/science.adk9227
• 发表日期: 2024-05-17
• 关键词: amplified spontaneous emission; optimization; chemistry; strategy; DESIGN; robust; IMPACT

摘要

Contemporary materials discovery requires intricate sequences of synthesis, formulation, and characterization that often span multiple locations with specialized expertise or instrumentation. To accelerate these workflows, we present a cloud-based strategy that enabled delocalized and asynchronous design-make-test-analyze cycles. We showcased this approach through the exploration of molecular gain materials for organic solid-state lasers as a frontier application in molecular optoelectronics. Distributed robotic synthesis and in-line property characterization, orchestrated by a cloud-based artificial intelligence experiment planner, resulted in the discovery of 21 new state-of-the-art materials. Gram-scale synthesis ultimately allowed for the verification of best-in-class stimulated emission in a thin-film device. Demonstrating the asynchronous integration of five laboratories across the globe, this workflow provides a blueprint for delocalizing-and democratizing-scientific discovery.