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作者：Xie, Zhenfei; Lin, Ying-Cing; Steichen, Jon M.; Ozorowski, Gabriel; Kratochvil, Sven; Ray, Rashmi; Torres, Jonathan L.; Liguori, Alessia; Kalyuzhniy, Oleksandr; Wang, Xuesong; Warner, John E.; Weldon, Stephanie R.; Dale, Gordon A.; Kirsch, Kathrin H.; Nair, Usha; Baboo, Sabyasachi; Georgeson, Erik; Adachi, Yumiko; Kubitz, Michael; Jackson, Abigail M.; Richey, Sara T.; Volk, Reid M.; Lee, Jeong Hyun; Diedrich, Jolene K.; Prum, Thavaleak; Falcone, Samantha; Himansu, Sunny; Carfi, Andrea; Yates III, John R.; Paulson, James C.; Sok, Devin; Ward, Andrew B.; Schief, William R.; Batista, Facundo D.
作者单位：Scripps Research Institute; International AIDS Vaccine Initiative; Scripps Research Institute; Scripps Research Institute; Scripps Research Institute; Scripps Research Institute; Massachusetts Institute of Technology (MIT)
摘要：INTRODUCTION Broadly neutralizing antibodies (bnAbs) isolated from HIV-1-infected patients demonstrate that the humoral immune system can develop effective antibody responses to HIV, even if those antibodies are rare and the result of a somewhat winding journey. Germline-targeting (GT) vaccination seeks to induce bnAbs through sequential immunization. To overcome the relatively low affinity of many germline precursors to bnAbs to the HIV-1 envelope protein (Env), precursors to bnAbs are identi...
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作者：Contaxis, Nicole; Badger, Kelsey; Bohman, Lena; Gonzales, Sara; Kim, Seonyoung; Koshoffer, Amy; Milliken, Genevieve; Newman, Jess; Otsuji, Reid; Renirie, Rebecca; Smith, Katy; Urmi, Ummea; Yarnell, Amy; Ye, Hao; Yee, Michelle
作者单位：New York University; University System of Ohio; Ohio State University; Hofstra University; Northwell Health; Northwell Health; Northwestern University; Feinberg School of Medicine; Washington University (WUSTL); Saint Louis University; University System of Ohio; University of Cincinnati; University of Tennessee System; University of Tennessee Health Science Center; University of California System; University of California San Diego; Central Michigan University; Saint Louis University; University System of Maryland; University of Maryland Baltimore; University of Pennsylvania
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作者：Couzin-Frankel, Jennifer
摘要：Studying cardiac effects of extreme exercise could yield clues to atrial fibrillation
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作者：Nemudraia, Anna; Nemudryi, Artem; Wiedenheft, Blake
作者单位：Montana State University System; Montana State University Bozeman
摘要：Genome editing with CRISPR RNA-guided endonucleases generates DNA breaks that are resolved by cellular DNA repair machinery. However, analogous methods to manipulate RNA remain unavailable. We show that site-specific RNA breaks generated with type-III CRISPR complexes are repaired in human cells and that this repair can be used for programmable deletions in human transcripts to restore gene function. Collectively, this work establishes a technology for precise RNA manipulation with potential t...
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作者：Schwab, Stephen D.; Singh, Manasvini
作者单位：University of Texas System; University of Texas at San Antonio; Carnegie Mellon University
摘要：Power-the asymmetric control of valued resources-affects most human interactions. Although power is challenging to study with real-world data, a distinctive dataset allowed us to do so within the critical context of doctor-patient relationships. Using 1.5 million quasi-random assignments in US military emergency departments, we examined how power differentials between doctor and patient (measured by using differences in military ranks) affect physician behavior. Our findings indicate that powe...
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作者：Wadman, Meredith
摘要：Universities could no longer store Medicare and Medicaid data, and costs would rise
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作者：Cho, Adrian
摘要：Aging infrastructure there cannot support suite of new telescopes, agency says
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作者：Warren, Matthew
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作者：Haswell, Elizabeth
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作者：Ruba, Ashley
