2024

最新文章

• Secrets of Women: Gender, Generation, and the Origins of Human Dissection AI翻译
  作者：Nummedal, Tara
  作者单位：Brown University
• The Experiential Caribbean: Creating Knowledge and Healing in the Early Modern Atlantic AI翻译
  作者：Pawley, Emily
• Wild by Design: The Rise of Ecological Restoration AI翻译
  作者：Guerrini, Anita
• Water-hydroxide trapping in cobalt tungstate for proton exchange membrane water electrolysis AI翻译
  作者：Ram, Ranit; Xia, Lu; Benzidi, Hind; Guha, Anku; Golovanova, Viktoria; Garzon Manjon, Alba; Llorens Rauret, David; Sanz Berman, Pol; Dimitropoulos, Marinos; Mundet, Bernat; Pastor, Ernest; Celorrio, Veronica; Mesa, Camilo A.; Das, Aparna M.; Pinilla-Sanchez, Adrian; Gimenez, Sixto; Arbiol, Jordi; Lopez, Nuria; Garcia de Arquer, F. Pelayo
  作者单位：Barcelona Institute of Science & Technology; Universitat Politecnica de Catalunya; Institut de Ciencies Fotoniques (ICFO); Barcelona Institute of Science & Technology; Consejo Superior de Investigaciones Cientificas (CSIC); Autonomous University of Barcelona; Barcelona Institute of Science & Technology; Catalan Institute of Nanoscience & Nanotechnology (ICN2); Barcelona Institute of Science & Technology; Autonomous University of Barcelona; Universite de Rennes; Centre National de la Recherche Scientifique (CNRS); University of Tokyo; Diamond Light Source; Universitat Jaume I; ICREA
  摘要：The oxygen evolution reaction is the bottleneck to energy-efficient water-based electrolysis for the production of hydrogen and other solar fuels. In proton exchange membrane water electrolysis (PEMWE), precious metals have generally been necessary for the stable catalysis of this reaction. In this work, we report that delamination of cobalt tungstate enables high activity and durability through the stabilization of oxide and water-hydroxide networks of the lattice defects in acid. The resulti...
• No place like home AI翻译
  作者：Clery, Daniel
• Wheat scientists unveil historic 'gold mine' Genome sequencing of century- old collection could help breeders restore long-lost traits AI翻译
  作者：Stokstad, Erik
• Study backs diabetes drug as safe AI翻译
  作者：Brainard, Jeffrey
• Cellular senescence in normal physiology AI翻译
  作者：de Magalhes, Joo Pedro
  作者单位：University of Birmingham
• Combined JAK inhibition and PD-1 immunotherapy for non-small cell lung cancer patients AI翻译
  作者：Mathew, Divij; Marmarelis, Melina E.; Foley, Caitlin; Bauml, Joshua M.; Ye, Darwin; Ghinnagow, Reem; Ngiow, Shin Foong; Klapholz, Max; Jun, Soyeong; Zhang, Zhaojun; Zorc, Robert; Davis, Christiana W.; Diehn, Maximillian; Giles, Josephine R.; Huang, Alexander C.; Hwang, Wei-Ting; Zhang, Nancy R.; Schoenfeld, Adam J.; Carpenter, Erica L.; Langer, Corey J.; Wherry, E. John; Minn, Andy J.
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Stanford University; Stanford Cancer Institute; Stanford University; University of Pennsylvania; University of Pennsylvania; Memorial Sloan Kettering Cancer Center
  摘要：Persistent inflammation driven by cytokines such as type-one interferon (IFN-I) can cause immunosuppression. We show that administration of the Janus kinase 1 (JAK1) inhibitor itacitinib after anti-PD-1 (programmed cell death protein 1) immunotherapy improves immune function and antitumor responses in mice and results in high response rates (67%) in a phase 2 clinical trial for metastatic non-small cell lung cancer. Patients who failed to respond to initial anti-PD-1 immunotherapy but responde...
• JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma AI翻译
  作者：Zak, Jaroslav; Pratumchai, Isaraphorn; Marro, Brett S.; Marquardt, Kristi L.; Zavareh, Reza Beheshti; Lairson, Luke L.; Oldstone, Michael B. A.; Varner, Judith A.; Hegerova, Livia; Cao, Qing; Farooq, Umar; Kenkre, Vaishalee P.; Bachanova, Veronika; Teijaro, John R.
  作者单位：Scripps Research Institute; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Scripps Research Institute; University of California System; University of California San Diego; University of Washington; University of Washington Seattle; University of Minnesota System; University of Minnesota Twin Cities; University of Iowa; University of Wisconsin System; University of Wisconsin Madison; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Unleashing antitumor T cell activity by checkpoint inhibitor immunotherapy is effective in cancer patients, but clinical responses are limited. Cytokine signaling through the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway correlates with checkpoint immunotherapy resistance. We report a phase I clinical trial of the JAK inhibitor ruxolitinib with anti-PD-1 antibody nivolumab in Hodgkin lymphoma patients relapsed or refractory following checkpoint inhibitor im...