2024

最新文章

• Homeocurvature adaptation of phospholipids to pressure in deep-sea invertebrates AI翻译
  作者：Winnikoff, Jacob R.; Milshteyn, Daniel; Vargas-Urbano, Sasiri J.; Pedraza-Joya, Miguel A.; Armando, Aaron M.; Quehenberger, Oswald; Sodt, Alexander; Gillilan, Richard E.; Dennis, Edward A.; Lyman, Edward; Haddock, Steven H. D.; Budin, Itay
  作者单位：University of California System; University of California San Diego; Harvard University; Monterey Bay Aquarium Research Institute; University of California System; University of California Santa Cruz; University of Delaware; University of California System; University of California San Diego; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
  摘要：Hydrostatic pressure increases with depth in the ocean, but little is known about the molecular bases of biological pressure tolerance. We describe a mode of pressure adaptation in comb jellies (ctenophores) that also constrains these animals' depth range. Structural analysis of deep-sea ctenophore lipids shows that they form a nonbilayer phase at pressures under which the phase is not typically stable. Lipidomics and all-atom simulations identified phospholipids with strong negative spontaneo...
• Protect wetlands from legacy plastics AI翻译
  作者：Zhao, Xiaoli; Wu, Xiaowei; Yu, Dandan; Lundquist, Carolyn; Li, Chengjun; Zhong, Huan
  作者单位：Chinese Research Academy of Environmental Sciences; Nanjing University of Information Science & Technology; Nanjing Institute of Environmental Sciences, Ministry of Ecology & Environment; University of Auckland; National Institute of Water & Atmospheric Research (NIWA) - New Zealand; Guangzhou University; Nanjing University; Trent University
• Molecular recognition with resolution below 0.2 angstroms through thermoregulatory oscillations in covalent organic frameworks AI翻译
  作者：Hu, Yiming; Sengupta, Bratin; Long, Hai; Wayment, Lacey J.; Ciora, Richard; Jin, Yinghua; Wu, Jingyi; Lei, Zepeng; Friedman, Kaleb; Chen, Hongxuan; Yu, Miao; Zhang, Wei
  作者单位：University of Colorado System; University of Colorado Boulder; State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY; United States Department of Energy (DOE); National Renewable Energy Laboratory - USA
  摘要：Crystalline materials with uniform molecular-sized pores are desirable for a broad range of applications, such as sensors, catalysis, and separations. However, it is challenging to tune the pore size of a single material continuously and to reversibly distinguish small molecules (below 4 angstroms). We synthesized a series of ionic covalent organic frameworks using a tetraphenoxyborate linkage that maintains meticulous synergy between structural rigidity and local flexibility to achieve contin...
• Simulations predict intermediate-mass black hole formation in globular clusters AI翻译
  作者：Fujii, Michiko S.; Wang, Long; Tanikawa, Ataru; Hirai, Yutaka; Saitoh, Takayuki R.
  作者单位：University of Tokyo; Sun Yat Sen University; Fukui Prefectural University; University of Notre Dame; Tohoku University; Kobe University
  摘要：The formation process of intermediate-mass black holes (IMBHs), defined as those between 100 and 10(5) solar masses (M (circle dot)), is debated. One potential origin is the growth of less-massive black holes merging with stars and compact objects within globular clusters (GCs). However, previous simulations have indicated that this process only produces IMBHs under 500 M (circle dot) before gravitational wave recoil ejects them from the GC. We performed star-by-star simulations of GC formatio...
• Improve trans policies in Brazil's universities AI翻译
  作者：Goebel, Luan Gabriel Araujo; Pfeil, Cello Latini; Gois, Isis; Rodrigues, Felipe Behrends; Pagan, Alice Alexandre; de Souza, Lucy Gomes
  作者单位：Universidade do Estado de Mato Grosso; Universidade Federal do Rio de Janeiro; Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Mato Grosso; Universidade Federal de Amazonas
• Structure of methylaluminoxane (MAO): Extractable [Al(CH3)2]+ for precatalyst activation AI翻译
  作者：Luo, Lubin; Younker, Jarod M.; Zabula, Alexander V.
  摘要：Methylaluminoxane (MAO) is used as a precatalyst activator for million ton-scale production of commercial polyolefins, but its precise structure and associated activation mechanisms have been a fundamental research puzzle for more than 40 years. We report here the crystallographic characterization of an active MAO component, which reveals a discrete two-dimensional sheet cluster [Al33O26(CH3)(47)][Al(CH3)(3)](2) featuring two trimethylaluminum units, Al(CH3)(3), coordinated to two unsaturated ...
• Structural basis for odorant recognition of the insect odorant receptor OR-Orco heterocomplex AI翻译
  作者：Wang, Yidong; Qiu, Liang; Wang, Bing; Guan, Zeyuan; Dong, Zhi; Zhang, Jie; Cao, Song; Yang, Lulu; Wang, Bo; Gong, Zhou; Zhang, Liwei; Ma, Weihua; Liu, Zhu; Zhang, Delin; Wang, Guirong; Yin, Ping
  作者单位：Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; Hubei Hongshan Laboratory; Huazhong Agricultural University; Chinese Academy of Agricultural Sciences; Institute of Plant Protection, CAAS; Chinese Academy of Sciences; Innovation Academy for Precision Measurement Science & Technology, CAS; China Agricultural University
  摘要：Insects detect and discriminate a diverse array of chemicals using odorant receptors (ORs), which are ligand-gated ion channels comprising a divergent odorant-sensing OR and a conserved odorant receptor co-receptor (Orco). In this work, we report structures of the ApOR5-Orco heterocomplex from the pea aphid Acyrthosiphon pisum alone and bound to its known activating ligand, geranyl acetate. In these structures, three ApOrco subunits serve as scaffold components that cannot bind the ligand and ...
• Gene therapy gets broader OK AI翻译
  作者：Brainard, Jeffrey
• Mef2d potentiates type-2 immune responses and allergic lung inflammation AI翻译
  作者：Szeto, Aydan C. H.; Clark, Paula A.; Ferreira, Ana C. F.; Heycock, Morgan; Griffiths, Emma L.; Jou, Eric; Mannion, Jonathan; Luan, Shi-Lu; Storrar, Sophie; Knolle, Martin D.; Kozik, Patrycja; Jolin, Helen E.; Fallon, Padraic G.; Mckenzie, Andrew N. J.
  作者单位：MRC Laboratory Molecular Biology; University of Cambridge; Trinity College Dublin; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; University of Cambridge
  摘要：Innate lymphoid cells (ILCs) and adaptive T lymphocytes promote tissue homeostasis and protective immune responses. Their production depends on the transcription factor GATA3, which is further elevated specifically in ILC2s and T helper 2 cells to drive type-2 immunity during tissue repair, allergic disorders, and anti-helminth immunity. The control of this crucial up-regulation is poorly understood. Using CRISPR screens in ILCs we identified previously unappreciated myocyte-specific enhancer ...
• Bidirectional fluid flow inspired by nature AI翻译
  作者：Funk, Michael; Lavine, Marc S.; Vignieri, Sach; Lopez, Bianca; Funk, Michael A.; Yeston, Jake S.; Stern, Peter; Osborne, Ian S.; Berry, Brandon; Kelly, Priscilla N.; Smith, Jesse; Suleymanov, Yury; Isles, Hannah; VanHook, Annalisa M.