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作者:Ahmad, Muhammad Arslan
作者单位:Shenzhen University
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作者:Wearing, Emily R.; Yeh, Yu-Cheng; Terrones, Gianmarco G.; Parikh, Seren G.; Kevlishvili, Ilia; Kulik, Heather J.; Schindler, Corinna S.
作者单位:University of Michigan System; University of Michigan; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of British Columbia; University of British Columbia; British Columbia Cancer Agency
摘要:The aza Paterno-Buchi reaction is a [2+2]-cycloaddition reaction between imines and alkenes that produces azetidines, four-membered nitrogen-containing heterocycles. Currently, successful examples rely primarily on either intramolecular variants or cyclic imine equivalents. To unlock the full synthetic potential of aza Paterno-Buchi reactions, it is essential to extend the reaction to acyclic imine equivalents. Here, we report that matching of the frontier molecular orbital energies of alkenes...
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作者:Brainard, Jeffrey
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作者:Zhao, Jiawei; Chen, Andy Q.; Ryu, Jaewook; del Marmol, Josefina
作者单位:Harvard University; Harvard Medical School; Howard Hughes Medical Institute
摘要:Most insects, including human-targeting mosquitoes, detect odors through odorant-activated ion channel complexes consisting of a divergent odorant-binding subunit (OR) and a conserved co-receptor subunit (Orco). As a basis for understanding how odorants activate these heteromeric receptors, we report here cryo-electron microscopy structures of two different heteromeric odorant receptor complexes containing ORs from disease-vector mosquitos Aedes aegypti or Anopheles gambiae. These structures r...
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作者:Brainard, Jeffrey
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作者:Laxminarayan, Ramanan; Gleason, Alec; Sheen, Justin; Saad-Roy, Chadi M.; Metcalf, C. Jessica; Palmer, Guy H.; Fevre, Eric M.
作者单位:Princeton University; Princeton University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Washington State University; University of Nairobi; CGIAR; International Livestock Research Institute (ILRI); University of Liverpool
摘要:Broader coverage can have economic, climate-related, animal welfare, and human health benefits
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作者:Ortega, Rodrigo Perez; Basilio, Humberto
摘要:Researchers see creation of new high-level science secretariat as a good sign Researchers see creation of new high-level science secretariat as a good sign
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作者:Stokstad, Erik
摘要:Insecticides made of RNA could offer a safer and more targeted weapon against crop pests
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作者:Thorp, H. Holden
摘要:Jonathan Haidt's new book, The Anxious Generation: How the Great Rewiring of Childhood Is Causing an Epidemic of Mental Illness, is a hot seller that makes the case that smartphones and social media are largely responsible for the current mental health crisis among young people and that restricting their use below certain ages (14 for smartphones and 16 for social media) can have a positive effect on reversing or slowing the problem. A social psychologist at New York University Stern School of...
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作者:Stimpson, Ashley
摘要:The former biodiversity hot spot had become a classic example of extinction