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作者：Lyu, Jiankun; Kapolka, Nicholas; Gumpper, Ryan; Alon, Assaf; Wang, Liang; Jain, Manish K.; Barros-Alvarez, Ximena; Sakamoto, Kensuke; Kim, Yoojoong; DiBerto, Jeffrey; Kim, Kuglae; Glenn, Isabella S.; Tummino, Tia A.; Huang, Sijie; Irwin, John J.; Tarkhanova, Olga O.; Moroz, Yurii; Skiniotis, Georgios; Kruse, Andrew C.; Shoichet, Brian K.; Roth, Bryan L.
作者单位：University of California System; University of California San Francisco; Rockefeller University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Harvard University; Harvard Medical School; Stanford University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); Ministry of Education & Science of Ukraine; Taras Shevchenko National University of Kyiv; Enamine Ltd; Stanford University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
摘要：AlphaFold2 (AF2) models have had wide impact but mixed success in retrospective ligand recognition. We prospectively docked large libraries against unrefined AF2 models of the sigma(2) and serotonin 2A (5-HT2A) receptors, testing hundreds of new molecules and comparing results with those obtained from docking against the experimental structures. Hit rates were high and similar for the experimental and AF2 structures, as were affinities. Success in docking against the AF2 models was achieved de...
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作者：Hussein, Rana; Graca, Andre; Forsman, Jack; Aydin, A. Orkun; Hall, Michael; Gaetcke, Julia; Chernev, Petko; Wendler, Petra; Dobbek, Holger; Messinger, Johannes; Zouni, Athina; Schroder, Wolfgang P.
作者单位：Humboldt University of Berlin; Umea University; Uppsala University; University of Potsdam; Umea University
摘要：Photosystem II starts the photosynthetic electron transport chain that converts solar energy into chemical energy and thus sustains life on Earth. It catalyzes two chemical reactions: water oxidation to molecular oxygen and plastoquinone reduction. Coupling of electron and proton transfer is crucial for efficiency; however, the molecular basis of these processes remains speculative owing to uncertain water binding sites and the lack of experimentally determined hydrogen positions. We thus coll...
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作者：Kovarik, Stepan; Schlitz, Richard; Vishwakarma, Aishwarya; Ruckert, Dominic; Gambardella, Pietro; Stepanow, Sebastian
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Laboratories for Materials Science & Technology (EMPA)
摘要：Control over quantum systems is typically achieved by time-dependent electric or magnetic fields. Alternatively, electronic spins can be controlled by spin-polarized currents. Here, we demonstrate coherent driving of a single spin by a radiofrequency spin-polarized current injected from the tip of a scanning tunneling microscope into an organic molecule. With the excitation of electron paramagnetic resonance, we established dynamic control of single spins by spin torque using a local electric ...
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作者：Whiteley, Andrew E.; Ma, Danhui; Wang, Lihua; Yu, Seok-Yeong; Yin, Claire; Price, Trevor T.; Simon, Brennan G.; Xu, Katie R.; Marsh, Kathleen A.; Brockman, Maegan L.; Prioleau, Tatiana M.; Zhou, Katherine I.; Cui, Xiuyu; Fecci, Peter E.; Jeck, William R.; McCall, Chad M.; Neff, Jadee L.; Sipkins, Dorothy A.
作者单位：Duke University; Duke University; Duke University; Stanford University; University System of Ohio; Case Western Reserve University; Wake Forest University; Emory University
摘要：The molecular mechanisms that regulate breast cancer cell (BCC) metastasis and proliferation within the leptomeninges (LM) are poorly understood, which limits the development of effective therapies. In this work, we show that BCCs in mice can invade the LM by abluminal migration along blood vessels that connect vertebral or calvarial bone marrow and meninges, bypassing the blood-brain barrier. This process is dependent on BCC engagement with vascular basement membrane laminin through expressio...
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作者：de Vrieze, Jop
摘要：Biophysics prize from Tel Aviv University bears the family's name despite its role in opioid epidemic
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作者：Tsuda, Katsutoshi; Maeno, Akiteru; Otake, Ayako; Kato, Kae; Tanaka, Wakana; Hibara, Ken-Ichiro; Nonomura, Ken-Ichi
作者单位：Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Graduate University for Advanced Studies - Japan; Hiroshima University
摘要：Plant stems comprise nodes and internodes that specialize in solute exchange and elongation. However, their boundaries are not well defined, and how these basic units arise remains elusive. In rice with clear nodes and internodes, we found that one subclade of class I knotted1-like homeobox (KNOX1) genes for shoot meristem indeterminacy restricts node differentiation and allows internode formation by repressing YABBY genes for leaf development and genes from another node-specific KNOX1 subclad...
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作者：Warren, Matthew
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作者：Wu, Da; Zhao, Zhengpu; Lin, Bo; Song, Yizhi; Qi, Jiajie; Jiang, Jian; Yuan, Zifeng; Cheng, Bowei; Zhao, Mengze; Tian, Ye; Wang, Zhichang; Wu, Muhong; Bian, Ke; Liu, Kai-Hui; Xu, Li-Mei; Zeng, Xiao Cheng; Wang, En-Ge; Jiang, Ying
作者单位：Peking University; City University of Hong Kong; Peking University; Peking University; Peking University; Chinese Academy of Sciences; Liaoning University; Liaoning University; Peking University; Tsinghua University; Collaborative Innovation Center of Quantum Matter; City University of Hong Kong; Peking University
摘要：Low-dimensional water transport can be drastically enhanced under atomic-scale confinement. However, its microscopic origin is still under debate. In this work, we directly imaged the atomic structure and transport of two-dimensional water islands on graphene and hexagonal boron nitride surfaces using qPlus-based atomic force microscopy. The lattice of the water island was incommensurate with the graphene surface but commensurate with the boron nitride surface owing to different surface electr...
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作者：Liu, Dongxin; Fu, Jiarui; Elishav, Oren; Sakakibara, Masaya; Yamanouchi, Kaoru; Hirshberg, Barak; Nakamuro, Takayuki; Nakamura, Eiichi
作者单位：University of Tokyo; Tel Aviv University; Tel Aviv University; Yale University
摘要：Upon melting, the molecules in a crystal explore numerous configurations, reflecting an increase in disorder. The molar entropy of disorder can be defined by Boltzmann's formula Delta S-d = Rln(W-d), where W-d is the increase in the number of microscopic states, so far inaccessible experimentally. We found that the Arrhenius frequency factor A of the electron diffraction signal decay provides W-d through an experimental equation A = A(INT)W(d), where A(INT) is an inelastic scattering cross sec...
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作者：Warren, Matthew
