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作者：El Albani, Abderrazak; Mazurier, Arnaud; Edgecombe, Gregory D.; Azizi, Abdelfattah; El Bakhouch, Asmaa; Berks, Harry O.; Bouougri, El Hafid; Chraiki, Ibtissam; Donoghue, Philip C. J.; Fontaine, Claude; Gaines, Robert R.; Ghnahalla, Mohamed; Meunier, Alain; Trentesaux, Alain; Paterson, John R.
作者单位：Universite de Poitiers; Natural History Museum London; Cadi Ayyad University of Marrakech; University of Bristol; Cadi Ayyad University of Marrakech; Claremont Colleges; Pomona College; Universite du Littoral-Cote-d'Opale; Universite de Lille; University of New England
摘要：Knowledge of Cambrian animal anatomy is limited by preservational processes that result in compaction, size bias, and incompleteness. We documented pristine three-dimensional (3D) anatomy of trilobites fossilized through rapid ash burial from a pyroclastic flow entering a shallow marine environment. Cambrian ellipsocephaloid trilobites from Morocco are articulated and undistorted, revealing exquisite details of the appendages and digestive system. Previously unknown anatomy includes a soft-tis...
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作者：Rees, Jonathan
作者单位：Colorado State University System; Colorado State University Pueblo
摘要：A journalist invites readers on an expansive romp through the artificial cryosphere
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作者：Mayra, Frans
作者单位：Tampere University
摘要：Games are powerful tools that must be played with care
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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
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作者：Mayra, Frans
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作者：Brainard, Jeffrey
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作者：Harvey, Judson W.; Kampf, Stephanie K.
作者单位：United States Department of the Interior; United States Geological Survey; Colorado State University System; Colorado State University Fort Collins
摘要：A river's journey typically starts in temporary streams that flow sporadically when wet conditions prevail. During dry periods, streamflow slows and then stops as the waters recede below ground. When streamflow resumes over recently dry streambeds, it mobilizes and transports energy-rich materials and nutrients that stimulate aquatic ecosystem productivity downstream ( 1 ). Temporary streams are present in all climate zones ( 1 - 3 ), and most of the world's streams and rivers do not flow cont...
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作者：Neumann, Edwin N.; Bertozzi, Tessa M.; Wu, Elaine; Serack, Fiona; Harvey, John W.; Brauer, Pamela P.; Pirtle, Catherine P.; Coffey, Alissa; Howard, Michael; Kamath, Nikita; Lenz, Kenney; Guzman, Kenia; Raymond, Michael H.; Khalil, Ahmad S.; Deverman, Benjamin E.; Minikel, Eric Vallabh; Vallabh, Sonia M.; Weissman, Jonathan S.
作者单位：Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Boston University; Boston University; Harvard University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP halts prion disease progression. In this study, we describe Coupled Histone tail for Autoinhibition Release of Methyltransferase (CHARM), a compact, enzyme-free epigenetic editor capable of silencing transcription through programmable DNA methylation. Using a histone H3 tail-Dnmt3l fusion, CHARM recrui...
