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作者：Li, Jinghao; Tang, Pengcheng; Fan, Yang; Lu, Hongjian
作者单位：Guizhou University; Nanjing University
摘要：Given the prevalence of nitrogen-containing heterocycles in bioactive molecules, inserting a nitrogen atom into a saturated ring offers a powerful yet underdeveloped scaffold-hopping strategy for expanding drug-like chemical space. In this study, we present a skeletal editing method that directly inserts a nitrogen atom into pyrrolidine rings, converting them into tetrahydropyridazine scaffolds under mild, operationally simple conditions with readily available O-diphenylphosphinyl hydroxylamin...
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作者：Rogelj, Joeri; Rajamani, Lavanya
作者单位：Imperial College London; Imperial College London; International Institute for Applied Systems Analysis (IIASA); University of Oxford; University of Oxford
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作者：Falk, Adam
作者单位：Wildlife Conservation Society
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作者：Russo-Tait, Tatiane; Blanco, Summer; Bonilla-Silva, Eduardo
作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; Duke University
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作者：Whitaker, Weston R.; Russ, Zachary N.; Stanley Shepherd, Elizabeth; Popov, Lauren M.; Louie, Alexander; Lam, Kathy; Zong, David M.; Gill, Clare C. C.; Gehrig, Jeanette L.; Rishi, Harneet S.; Tan, Jessica A.; Buness, Areta; Godoy, Janeth; Banta, Domenique; Jaidka, Sonia; Wilson, Katheryne; Flood, Jake; Bukshpun, Polina; Yocum, Richard; Cook, David N.; Warsi, Tariq; Mclean, Lachy; Sonnenburg, Justin L.; Deloache, William C.
作者单位：Stanford University; Chan Zuckerberg Initiative (CZI); Stanford University
摘要：Precision microbiome programming for therapeutic applications is limited by challenges in achieving reproducible colonic colonization. Previously, we created an exclusive niche that we used to engraft engineered bacteria into diverse microbiota in mice by using a porphyran prebiotic. Building on this approach, we have now engineered conditional attenuation into a porphyran-utilizing strain of Phocaeicola vulgatus by replacing native essential gene regulation with a porphyran-inducible promoter...
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作者：Cambronero-Heinrichs, Juan Carlos
作者单位：University of Padua
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作者：Cho, Adrian
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作者：Mann, Adam
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作者：Pang, Kai; Xia, Yuxing; Liu, Xiaoting; Tong, Wenhao; Li, Xiaotong; Li, Chenyang; Zhao, Wenbo; Chen, Yan; Qin, Huasong; Fang, Wenzhang; Peng, Li; Liu, Yilun; Gao, Weiwei; Xu, Zhen; Liu, Yingjun; Gao, Chao
作者单位：Zhejiang University
摘要：Aerogels are known for their high porosity and very low density and can be made from a range of materials, but are limited by structural instability under extreme thermomechanical conditions. We report on 194 types of dome-celled ultralight aerogels that maintain superior elasticity spanning from 4.2 kelvin (K) to 2273 K, realized by a two-dimensional channel-confined chemistry method. Such aerogels exhibit superelasticity under 99% strain for 20,000 cycles and thermal shock resistance at 2273...
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作者：Cabric, Vanja; Franco Parisotto, Yollanda; Park, Tyler; Akagbosu, Blossom; Zhao, Zihan; Lo, Yun; Shibu, Gayathri; Fisher, Logan; Paucar Iza, Yoselin A.; Leslie, Christina; Brown, Chrysothemis C.
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University
摘要：In the intestine, peripherally induced regulatory T (pTreg) cells play an essential role in suppressing inflammatory responses to food proteins. However, the identity of the antigen-presenting cells that instruct food-specific pTreg cells is poorly understood. We found that a subset of Thetis cells, TC IV, is required for food-specific pTreg cell differentiation. TC IV were almost exclusively present within mesenteric lymph nodes, suggesting that their presence underlies the phenomenon of oral...
