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作者：Russo-Tait, Tatiane; Blanco, Summer; Bonilla-Silva, Eduardo
作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; Duke University
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作者：Whitaker, Weston R.; Russ, Zachary N.; Stanley Shepherd, Elizabeth; Popov, Lauren M.; Louie, Alexander; Lam, Kathy; Zong, David M.; Gill, Clare C. C.; Gehrig, Jeanette L.; Rishi, Harneet S.; Tan, Jessica A.; Buness, Areta; Godoy, Janeth; Banta, Domenique; Jaidka, Sonia; Wilson, Katheryne; Flood, Jake; Bukshpun, Polina; Yocum, Richard; Cook, David N.; Warsi, Tariq; Mclean, Lachy; Sonnenburg, Justin L.; Deloache, William C.
作者单位：Stanford University; Stanford Medicine; Chan Zuckerberg Initiative (CZI); Stanford Medicine; Stanford University
摘要：Precision microbiome programming for therapeutic applications is limited by challenges in achieving reproducible colonic colonization. Previously, we created an exclusive niche that we used to engraft engineered bacteria into diverse microbiota in mice by using a porphyran prebiotic. Building on this approach, we have now engineered conditional attenuation into a porphyran-utilizing strain of Phocaeicola vulgatus by replacing native essential gene regulation with a porphyran-inducible promoter...
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作者：Rogelj, Joeri; Rajamani, Lavanya
作者单位：Imperial College London; Imperial College London; International Institute for Applied Systems Analysis (IIASA); University of Oxford; University of Oxford
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作者：Allen, Richard M.; Barski, Alexei; Berman, Micah; Bosch, Robert; Cho, Youngmin; Jiang, Xia Summer; Lee, Yun-Ling; Malkos, Steve; Mousavi, S. Mostafa; Robertson, Patrick; Spooner, Boone; Stogaitis, Marc; Thiruverahan, Nivetha; Wimpey, Greg
作者单位：Alphabet Inc.; Google Incorporated; University of California System; University of California Berkeley; Harvard University; Alphabet Inc.; Google Incorporated
摘要：Earthquake early-warning systems are increasingly being deployed as a strategy to reduce losses in earthquakes, but the regional seismic networks they require do not exist in many earthquake-prone countries. We use the global Android smartphone network to develop an earthquake detection capability, an alert delivery system, and a user feedback framework. Over 3 years of operation, the system detected an average of 312 earthquakes per month with magnitudes from M 1.9 to M 7.8 in Turkiye. Alerts...
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作者：Qiao, Zhuoran
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作者：Restar, Arjee J.; Gamarel, Kristi E.; Operario, Don
作者单位：Yale University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Emory University; Rollins School Public Health
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作者：Wu, Kejia; Jiang, Hanlun; Hicks, Derrick R.; Liu, Caixuan; Muratspahic, Edin; Ramelot, Theresa A.; Liu, Yuexuan; McNally, Kerrie; Kenny, Sebastian; Mihut, Andrei; Gaur, Amit; Coventry, Brian; Chen, Wei; Bera, Asim K.; Kang, Alex; Gerben, Stacey; Lamb, Mila Ya-Lan; Murray, Analisa; Li, Xinting; Kennedy, Madison A.; Yang, Wei; Song, Zihao; Schober, Gudrun; Brierley, Stuart M.; O'Neill, John; Gelb, Michael H.; Montelione, Gaetano T.; Derivery, Emmanuel; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of California System; University of California Berkeley; Rensselaer Polytechnic Institute; University of Washington; University of Washington Seattle; MRC Laboratory Molecular Biology; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; South Australian Health & Medical Research Institute (SAHMRI); Adelaide University; University of Adelaide
摘要：Intrinsically disordered proteins and peptides play key roles in biology, but a lack of defined structures and high variability in sequence and conformational preferences have made targeting such systems challenging. We describe a general approach for designing proteins that bind intrinsically disordered protein regions in diverse extended conformations with side chains fitting into complementary binding pockets. We used the approach to design binders for 39 highly diverse unstructured targets...
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作者：Roy, Dipan; Mehra, Poonam; Clark, Lisa; Mukkawar, Vaishnavi; Bellande, Kevin; Martin-Arevalillo, Raquel; Ghosh, Srayan; Ingole, Kishor D.; Bhagat, Prakash Kumar; Brown, Adrian; Sue-ob, Kawinnat; Jones, Andrew; Vermeer, Joop E. M.; Vernoux, Teva; Lilley, Kathryn; Mullineaux, Phil; Bechtold, Ulrike; Bennett, Malcolm J.; Sadanandom, Ari
作者单位：Durham University; University of Nottingham; University of Neuchatel; INRAE; Universite de Montpellier; Institut Agro; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Lyon 1; INRAE; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse (EPE); Communaute d'universites et etablissements de Toulouse (Comue); Centre National de la Recherche Scientifique (CNRS); Institut National Polytechnique de Toulouse; CNRS - Institute of Physics (INP); University of Cambridge; University of Liverpool; University of Essex
摘要：Reactive oxygen species (ROS) function as key signals in plant adaptation to environmental stresses, such as drought. Roots respond to transient water unavailability by temporarily ceasing branching through the acclimative response xerobranching. In this study, we report how a xerobranching stimulus triggers rapid changes of ROS levels in root nuclei, triggering redox-dependent multimerization of the auxin repressor protein IAA3. Mutations in specific cysteine residues of IAA3 disrupt redox-me...
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作者：Cabric, Vanja; Franco Parisotto, Yollanda; Park, Tyler; Akagbosu, Blossom; Zhao, Zihan; Lo, Yun; Shibu, Gayathri; Fisher, Logan; Paucar Iza, Yoselin A.; Leslie, Christina; Brown, Chrysothemis C.
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University
摘要：In the intestine, peripherally induced regulatory T (pTreg) cells play an essential role in suppressing inflammatory responses to food proteins. However, the identity of the antigen-presenting cells that instruct food-specific pTreg cells is poorly understood. We found that a subset of Thetis cells, TC IV, is required for food-specific pTreg cell differentiation. TC IV were almost exclusively present within mesenteric lymph nodes, suggesting that their presence underlies the phenomenon of oral...
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作者：Cohen, Jon; Kaiser, Jocelyn
