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作者：Graves Jr, Joseph L.; Goodman, Alan; Farina, Stacy; Moses, Yolanda
作者单位：University of North Carolina; North Carolina A&T State University; Howard University; University of California System; University of California Riverside
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作者：Qin, Biao; Jiang, Jianfeng; Wang, Lu; Guo, Quanlin; Zhang, Chenxi; Xu, Lin; Ni, Xing; Yin, Peng; Peng, Lian-Mao; Wang, Enge; Ding, Feng; Qiu, Chenguang; Liu, Can; Liu, Kaihui
作者单位：Peking University; Renmin University of China; Peking University; Peking University; Soochow University - China; Soochow University - China; Peking University; Peking University; Peking University; Tsinghua University; Collaborative Innovation Center of Quantum Matter; Suzhou Laboratory; Songshan Lake Materials Laboratory
摘要：Two-dimensional (2D) indium selenide, with its low effective mass, high thermal velocity, and exceptional electronic mobility, is a promising semiconductor for surpassing silicon electronics, but grown films have not achieved performance comparable with that of exfoliated micrometer-scale flakes. We report a solid-liquid-solid strategy that converts amorphous indium selenide films into pure-phase, high-crystallinity indium selenide wafers by creating an indium-rich liquid interface and maintai...
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作者：Rice, Benjamin L.; Raobson, Estelle; Miharisoa, Sylviane; Rebaliha, Mahery; Lewinski, Joseph; Raharinirina, Hanitriniaina; Golden, Christopher D.; Vecchi, Gabriel A.; Wesolowski, Amy; Grenfell, Bryan; Metcalf, C. Jessica E.
作者单位：Princeton University; University Antananarivo; Pasteur Network; Institut Pasteur Madagascar; Harvard University; Harvard T.H. Chan School of Public Health; Princeton University; Princeton University; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Princeton University
摘要：Extreme weather is common in high malaria burden areas and is likely to increase in severity owing to climate change-related severe weather events. Yet, data on infection rates after these events and the consequences for planning disease control programs remain rare. Data on malaria infection in the wake of major tropical cyclones in Madagascar show that infection is likely to rebound rapidly during the gaps in interventions that occur after extreme events. Relative to other control options, r...
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作者：Yang, Jason; Xu, Yunhan; Ziehr, David R.; Taylor, Martin S.; Valenstein, Max L.; Frenkel, Evgeni M.; Bush, Jack R.; Rutter, Kate; Stevanovski, Igor; Shi, Charlie Y.; Kesavan, Maheswaran; Pinto, Ricardo Mouro; Deveson, Ira; Bartel, David P.; Sabatini, David M.; Chivukula, Raghu R.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brown University; Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences; Garvan Institute of Medical Research; Murdoch Children's Research Institute; Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Laval University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of New South Wales Sydney; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Aggregation-prone polyglycine-containing proteins produced from expanded GGC repeats are implicated in an emerging family of neurodegenerative disorders. In this study, we showed that polyglycine itself forms aggregates that incorporate endogenous glycine-rich proteins, including FAM98B, a component of the transfer RNA (tRNA) ligase complex (tRNA-LC) that harbors the most glycine-rich sequence in the human proteome. Through this glycine-rich intrinsically disordered region (IDR), polyglycine s...
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作者：Kaur, Upneet; Wu, Hao; Cheng, Yifan; Narlikar, Geeta J.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Howard Hughes Medical Institute
摘要：Increasing the flanking DNA from 40 to 80 base pairs (bp) causes similar to 100-fold faster nucleosome sliding by INO80. A prevalent hypothesis posits that the Arp8 module within INO80 enables a ruler-like activity. Using cryogenic electron microscopy, we show that on nucleosomes with 40 bp of flanking DNA, the Arp8 module rotates 180 degrees away from the DNA. Deleting the Arp8 module enables rapid sliding irrespective of flanking DNA length. Thus, rather than enabling a ruler-like activity, ...
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作者：Robles-Gil, Alexa
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作者：Qiao, Zhuoran
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作者：Restar, Arjee J.; Gamarel, Kristi E.; Operario, Don
作者单位：Yale University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Emory University; Rollins School Public Health
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作者：Wu, Kejia; Jiang, Hanlun; Hicks, Derrick R.; Liu, Caixuan; Muratspahic, Edin; Ramelot, Theresa A.; Liu, Yuexuan; McNally, Kerrie; Kenny, Sebastian; Mihut, Andrei; Gaur, Amit; Coventry, Brian; Chen, Wei; Bera, Asim K.; Kang, Alex; Gerben, Stacey; Lamb, Mila Ya-Lan; Murray, Analisa; Li, Xinting; Kennedy, Madison A.; Yang, Wei; Song, Zihao; Schober, Gudrun; Brierley, Stuart M.; O'Neill, John; Gelb, Michael H.; Montelione, Gaetano T.; Derivery, Emmanuel; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of California System; University of California Berkeley; Rensselaer Polytechnic Institute; University of Washington; University of Washington Seattle; MRC Laboratory Molecular Biology; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; South Australian Health & Medical Research Institute (SAHMRI); University of Adelaide
摘要：Intrinsically disordered proteins and peptides play key roles in biology, but a lack of defined structures and high variability in sequence and conformational preferences have made targeting such systems challenging. We describe a general approach for designing proteins that bind intrinsically disordered protein regions in diverse extended conformations with side chains fitting into complementary binding pockets. We used the approach to design binders for 39 highly diverse unstructured targets...
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作者：Barilla, Rocky M.; Berard, Clara; Sun, Linyu; Sandhu, Sumiti; Zaghouani, Sarah; Iyer, Krishna S.; Altun, Gizem; Su, Chien-Wen; Deguine, Jacques; Singh, Vasundhara; Hou, Yu; Kusumakar, Kanupriya; Rutlin, Michael L.; Rao, Meenakshi; Zaghouani, Habib; Shi, Hai Ning; Xavier, Ramnik J.; Kuchroo, Vijay K.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; University of Minnesota System; University of Minnesota Twin Cities; Technical University of Munich; Helmholtz Association; German Cancer Research Center (DKFZ); Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Liangzhu Laboratory; Zhejiang University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; University of Missouri System; University of Missouri Columbia; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：Enteric nervous system (ENS)-derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is considerably lacking. Here, we characterized a primary enteric sensory neuron (PSN) subset producing the neuropeptides neuromedin U (NMU) and calcitonin gene-related peptide beta (CGRP beta) and coexpressing receptors for the type 2 cytokines interleukin-4 (IL-4) and IL-13. Type 2 cytokines amplified NMU...
