6757期

最新文章

• NIH suspends alleged 'gain-of-function' studies AI翻译
  作者：Cohen, Jon; Kaiser, Jocelyn
• RORing for oral tolerance AI翻译
  作者：Johansson, Cecilia
  作者单位：Imperial College London
• Polyglycine proteins leave transfer RNAs unglued Disruption of transfer RNA processing may unite the pathogenesis of CGG repeat expansion disorders AI翻译
  作者：Kapur, Mridu; Ackerman, Susan L.
  作者单位：University of California System; University of California San Diego; Howard Hughes Medical Institute
• Bridging the pyridine-pyridazine synthesis gap by skeletal editing AI翻译
  作者：Purins, Mikus; Nakahara, Hikaru; Levin, Mark D.
  作者单位：University of Chicago
  摘要：Pairs of heterocycles differing by a single constitutive ring atom can exhibit stark differences in the retrosynthetic disconnections available for their preparation. Such a synthesis gap is exemplified by pyridine and pyridazine. Pyridine (a six-membered C5N ring) has risen to prominence in discovery chemistry, its ease of assembly spurring further synthetic development. Despite a host of favorable properties, pyridazine (an analogous C4N2 ring) has comparatively lagged behind-a discrepancy a...
• Disorder meets its match AI翻译
  作者：Moses, Alan M.; Forman-Kay, Julie D.
  作者单位：University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto
• Midline assembloids reveal regulators of human axon guidance AI翻译
  作者：Onesto, Massimo M.; Amin, Neal D.; Pan, Chenjie; Chen, Xiaoyu; Kim, Ji-il; Reis, Noah; Kanton, Sabina; Valencia, Alfredo M.; Hudacova, Zuzana; McQueen, James P.; Tessier-Lavigne, Marc; Pasca, Sergiu P.
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University
  摘要：Organizers orchestrate cell patterning and axon guidance in the developing nervous system. Although nonhuman models have led to fundamental discoveries about floor plate (FP)-mediated midline organization, an experimental model of the human FP would enable insights into human neurodevelopment and midline connectivity. Here, we developed organoids resembling human FP (hFpOs) and assembled them with human spinal cord organoids (hSpOs) to generate midline assembloids (hMAs). We demonstrate that h...
• A new age of molecular chirality Advanced optical approaches reshape the frontiers of chiral sensing AI翻译
  作者：Smirnova, Olga
  作者单位：Leibniz Association; Max Born Institute for Nonlinear Optics & Short Term Spectroscopy; Technical University of Berlin; Technion Israel Institute of Technology
• ASB7 is a negative regulator of H3K9me3 homeostasis AI翻译
  作者：Zhou, Liwen; Chen, Zhenxuan; Zou, Yezi; Zhang, Xia; Wang, Zifeng; Zhu, Hongwen; Lin, Jiahui; Huang, Ziyao; Zheng, Lisi; Chen, Jiali; Xie, Miner; Zhang, Meifang; Zhang, Ruhua; Zhu, Minglu; Wang, Ziwen; Zhou, Hu; Gao, Song; Yin, Yuxin; Wu, Yuanzhong; Kang, Tiebang
  作者单位：State Key Lab Oncology South China; Sun Yat Sen University; Sun Yat Sen University; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; South China University of Technology; Peking University
  摘要：The maintenance of histone H3 lysine 9 trimethylation (H3K9me3) involves the recognition of preexisting modifications by heterochromatin protein 1 (HP1), which recruits the methyltransferase suppressor of variegation 3-9 homolog 1 (SUV39H1) to methylate the adjacent newly incorporated histones, establishing a positive feedback loop. However, how this positive feedback is restricted to maintain H3K9me3 homeostasis remains largely unknown. We performed an unbiased genome-scale CRISPR-Cas9 screen...
• Redox-regulated Aux/IAA multimerization modulates auxin responses AI翻译
  作者：Roy, Dipan; Mehra, Poonam; Clark, Lisa; Mukkawar, Vaishnavi; Bellande, Kevin; Martin-Arevalillo, Raquel; Ghosh, Srayan; Ingole, Kishor D.; Bhagat, Prakash Kumar; Brown, Adrian; Sue-ob, Kawinnat; Jones, Andrew; Vermeer, Joop E. M.; Vernoux, Teva; Lilley, Kathryn; Mullineaux, Phil; Bechtold, Ulrike; Bennett, Malcolm J.; Sadanandom, Ari
  作者单位：Durham University; University of Nottingham; University of Neuchatel; Institut Agro; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); INRAE; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; INRAE; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite de Toulouse; Institut National Polytechnique de Toulouse; University of Cambridge; University of Liverpool; University of Essex
  摘要：Reactive oxygen species (ROS) function as key signals in plant adaptation to environmental stresses, such as drought. Roots respond to transient water unavailability by temporarily ceasing branching through the acclimative response xerobranching. In this study, we report how a xerobranching stimulus triggers rapid changes of ROS levels in root nuclei, triggering redox-dependent multimerization of the auxin repressor protein IAA3. Mutations in specific cysteine residues of IAA3 disrupt redox-me...
• Molecular fossils show how life survived Snowball Earth AI翻译
  作者：Cutts, Elise