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作者：Mann, Adam
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作者：Graves Jr, Joseph L.; Goodman, Alan; Farina, Stacy; Moses, Yolanda
作者单位：University of North Carolina; North Carolina A&T State University; Howard University; University of California System; University of California Riverside
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作者：Qin, Biao; Jiang, Jianfeng; Wang, Lu; Guo, Quanlin; Zhang, Chenxi; Xu, Lin; Ni, Xing; Yin, Peng; Peng, Lian-Mao; Wang, Enge; Ding, Feng; Qiu, Chenguang; Liu, Can; Liu, Kaihui
作者单位：Peking University; Renmin University of China; Peking University; Peking University; Soochow University - China; Soochow University - China; Peking University; Peking University; Tsinghua University; Peking University; Collaborative Innovation Center of Quantum Matter; Suzhou Laboratory; Songshan Lake Materials Laboratory
摘要：Two-dimensional (2D) indium selenide, with its low effective mass, high thermal velocity, and exceptional electronic mobility, is a promising semiconductor for surpassing silicon electronics, but grown films have not achieved performance comparable with that of exfoliated micrometer-scale flakes. We report a solid-liquid-solid strategy that converts amorphous indium selenide films into pure-phase, high-crystallinity indium selenide wafers by creating an indium-rich liquid interface and maintai...
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作者：Rice, Benjamin L.; Raobson, Estelle; Miharisoa, Sylviane; Rebaliha, Mahery; Lewinski, Joseph; Raharinirina, Hanitriniaina; Golden, Christopher D.; Vecchi, Gabriel A.; Wesolowski, Amy; Grenfell, Bryan; Metcalf, C. Jessica E.
作者单位：Princeton University; University Antananarivo; Pasteur Network; Institut Pasteur Madagascar; Harvard University; Harvard T.H. Chan School of Public Health; Princeton University; Princeton University; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Princeton University
摘要：Extreme weather is common in high malaria burden areas and is likely to increase in severity owing to climate change-related severe weather events. Yet, data on infection rates after these events and the consequences for planning disease control programs remain rare. Data on malaria infection in the wake of major tropical cyclones in Madagascar show that infection is likely to rebound rapidly during the gaps in interventions that occur after extreme events. Relative to other control options, r...
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作者：Yang, Jason; Xu, Yunhan; Ziehr, David R.; Taylor, Martin S.; Valenstein, Max L.; Frenkel, Evgeni M.; Bush, Jack R.; Rutter, Kate; Stevanovski, Igor; Shi, Charlie Y.; Kesavan, Maheswaran; Pinto, Ricardo Mouro; Deveson, Ira; Bartel, David P.; Sabatini, David M.; Chivukula, Raghu R.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brown University; Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences; Garvan Institute of Medical Research; Murdoch Children's Research Institute; Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Laval University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of New South Wales Sydney; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Aggregation-prone polyglycine-containing proteins produced from expanded GGC repeats are implicated in an emerging family of neurodegenerative disorders. In this study, we showed that polyglycine itself forms aggregates that incorporate endogenous glycine-rich proteins, including FAM98B, a component of the transfer RNA (tRNA) ligase complex (tRNA-LC) that harbors the most glycine-rich sequence in the human proteome. Through this glycine-rich intrinsically disordered region (IDR), polyglycine s...
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作者：Onesto, Massimo M.; Amin, Neal D.; Pan, Chenjie; Chen, Xiaoyu; Kim, Ji-il; Reis, Noah; Kanton, Sabina; Valencia, Alfredo M.; Hudacova, Zuzana; McQueen, James P.; Tessier-Lavigne, Marc; Pasca, Sergiu P.
作者单位：Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford University
摘要：Organizers orchestrate cell patterning and axon guidance in the developing nervous system. Although nonhuman models have led to fundamental discoveries about floor plate (FP)-mediated midline organization, an experimental model of the human FP would enable insights into human neurodevelopment and midline connectivity. Here, we developed organoids resembling human FP (hFpOs) and assembled them with human spinal cord organoids (hSpOs) to generate midline assembloids (hMAs). We demonstrate that h...
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作者：Smirnova, Olga
作者单位：Leibniz Association; Max Born Institute for Nonlinear Optics & Short Term Spectroscopy; Technical University of Berlin; Technion Israel Institute of Technology
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作者：Zhou, Liwen; Chen, Zhenxuan; Zou, Yezi; Zhang, Xia; Wang, Zifeng; Zhu, Hongwen; Lin, Jiahui; Huang, Ziyao; Zheng, Lisi; Chen, Jiali; Xie, Miner; Zhang, Meifang; Zhang, Ruhua; Zhu, Minglu; Wang, Ziwen; Zhou, Hu; Gao, Song; Yin, Yuxin; Wu, Yuanzhong; Kang, Tiebang
作者单位：Sun Yat Sen University; State Key Lab Oncology South China; Sun Yat Sen University; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; South China University of Technology; Peking University
摘要：The maintenance of histone H3 lysine 9 trimethylation (H3K9me3) involves the recognition of preexisting modifications by heterochromatin protein 1 (HP1), which recruits the methyltransferase suppressor of variegation 3-9 homolog 1 (SUV39H1) to methylate the adjacent newly incorporated histones, establishing a positive feedback loop. However, how this positive feedback is restricted to maintain H3K9me3 homeostasis remains largely unknown. We performed an unbiased genome-scale CRISPR-Cas9 screen...
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作者：Nair, Aditya
作者单位：California Institute of Technology
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作者：O'Grady, Cathleen
