A wave of Thetis cells imparts tolerance to food antigens early in life

• 成果类型: Article
• 署名作者: Cabric, Vanja; Franco Parisotto, Yollanda; Park, Tyler; Akagbosu, Blossom; Zhao, Zihan; Lo, Yun; Shibu, Gayathri; Fisher, Logan; Paucar Iza, Yoselin A.; Leslie, Christina; Brown, Chrysothemis C.
• 署名单位: Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-11543
• DOI: 10.1126/science.adp0535
• 发表日期: 2025-07-17
• 页码: 268-274
• 关键词: regulatory t-cells; classical dendritic cells; peanut allergy; reg-cells; expression; differentiation; generation; immunity; TRIAL

摘要

In the intestine, peripherally induced regulatory T (pTreg) cells play an essential role in suppressing inflammatory responses to food proteins. However, the identity of the antigen-presenting cells that instruct food-specific pTreg cells is poorly understood. We found that a subset of Thetis cells, TC IV, is required for food-specific pTreg cell differentiation. TC IV were almost exclusively present within mesenteric lymph nodes, suggesting that their presence underlies the phenomenon of oral tolerance. A wave of TC IV differentiation in the periweaning period was associated with a window of opportunity for enhanced pTreg cell generation in response to food antigens. Our findings indicate that TC IV may represent a therapeutic target for the treatment of food-associated allergic and inflammatory diseases.