6760期

最新文章

• Predicting expression-altering promoter mutations with deep learning AI翻译
  作者：Jaganathan, Kishore; Ersaro, Nicole; Novakovsky, Gherman; Wang, Yuchuan; James, Terena; Schwartzentruber, Jeremy; Fiziev, Petko; Kassam, Irfahan; Cao, Fan; Hawe, Johann; Cavanagh, Henry; Lim, Ashley; Png, Grace; Mcrae, Jeremy; Banerjee, Abhimanyu; Kumar, Arvind; Ulirsch, Jacob; Zhang, Yan; Aguet, Francois; Wainschtein, Pierrick; Sundaram, Laksshman; Salcedo, Adriana; Panagiotopoulou, Sofia Kyriazopoulou; Aghamirzaie, Delasa; Padhi, Evin; Weng, Ziming; Dong, Shan; Smedley, Damian; Caulfield, Mark; O'Donnell-Luria, Anne; Rehm, Heidi L.; Sanders, Stephan J.; Kundaje, Anshul; Montgomery, Stephen B.; Ross, Mark T.; Farh, Kyle Kai-How
  作者单位：Illumina; Stanford University; University of California System; University of California San Francisco; University of Oxford; University of London; Queen Mary University London; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Stanford University; Stanford University; Stanford University
  摘要：Only a minority of patients with rare genetic diseases are presently diagnosed by exome sequencing, suggesting that additional unrecognized pathogenic variants may reside in noncoding sequence. In this work, we describe PromoterAI, a deep neural network that accurately identifies noncoding promoter variants that dysregulate gene expression. We show that promoter variants with predicted expression-altering consequences produce outlier expression at both the RNA and protein levels in thousands o...
• An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli AI翻译
  作者：Diercks, Christian S.; Sondermann, Philipp; Rong, Cynthia; Gillis, Thomas G.; Ban, Yahui; Wang, Celine; Dik, David A.; Schultz, Peter G.
  作者单位：Scripps Research Institute
  摘要：Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or enhanced protein functions. We describe an orthogonal DNA replication system in Escherichia coli based on the controlled expression of the replisome of bacteriophage T7 (T7-ORACLE). The system replicates circular plasmids that enable high transformation efficiencies and seamless integration into standard molecular biology w...
• Study reveals industrial-scale publishing fraud AI翻译
  作者：O'Grady, Cathleen
• The Feather Detective: Mystery, Mayhem, and the Magnificent Life of Roxie Laybourne AI翻译
  作者：Venkatraman, Vijaysree
• Immune system influence on physiology AI翻译
  作者：Nahrendorf, Matthias; Ginhoux, Florent; Swirski, Filip K.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Wurzburg; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Universite Paris Saclay; UNICANCER; Gustave Roussy; Institut National de la Sante et de la Recherche Medicale (Inserm); Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Chinese Academy of Sciences; Shanghai Jiao Tong University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
  摘要：The immune system's central function is to maintain homeostasis by guarding the organism against dangerous external and internal stressors. Immunity's operational toolbox contains diverse processes, such as phagocytosis, antigen recognition, cell killing, and secretion of cytokines and antibodies. Although immune cells interact with each other, they also communicate with cells typically associated with other organ systems, including the nervous, circulatory, metabolic, musculoskeletal, endocri...
• Strain-coupled, crystalline polymer-inorganic interfaces for efficient magnetoelectric sensing AI翻译
  作者：He, Binbin; He, Yuanyuan; Wang, Wenhui; Sun, Yingzhi; Kong, Shengwen; Huang, Jin; Ru, Yunfei; Qin, Bingchao; Ren, Huili; He, Jing; Zhao, Tianyi; Li, Jing; Lu, Jiong; Zhao, Li-Dong; Liu, Mingjie
  作者单位：Beihang University; Beihang University; National University of Singapore; Beihang University
  摘要：Magnetoelectric sensing holds promise for flexible sensors, offering precise detection of both electric and magnetic fields with minimal power consumption. However, its practical use has been constrained by weak magnetoelectric effects and limited overall performance, particularly under mechanical strain. Herein, we fabricated robust magnetoelectric polymer-inorganic nanocomposites through an interfacial cocrystallization strategy. By leveraging diazonium chemistry on vanadium diselenide (VSe2...
• Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice AI翻译
  作者：Hoyt, Laura R.; Liu, Elise; Olson, Eli C.; Jacobsen, Danielle R.; Siniscalco, Emily R.; Krier-Burris, Rebecca A.; Greenfield, Kara G.; Mcbride, Caleb D.; Alfajaro, Mia M.; Amat, Julien A. R.; Zhao, Zhe; Xu, Lan; Philip, Vivek; Verma, Aditi; Fourati, Slim; Senger, Donna L.; Zhang, Lingdi; Bunyavanich, Supinda; Glass, Sarah E.; Coffey, Robert J.; Wilen, Craig B.; Williams, Adam; Eisenbarth, Stephanie C.
  作者单位：Yale University; Yale University; Yale University; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Jackson Laboratory; Jewish General Hospital - Montreal; Lady Davis Institute; McGill University; Icahn School of Medicine at Mount Sinai; Vanderbilt University; Vanderbilt University; Vanderbilt University
  摘要：Food-specific immunoglobulin E (IgE) triggers life-threatening anaphylaxis; however, for unclear reasons, some people with food-specific IgE are asymptomatic upon allergen consumption. We studied strains of mice with different sensitivities to anaphylaxis when orally challenged with allergen to identify possible causes. In resistant C57BL/6 mice, intestinal goblet cells transported less food allergen than did anaphylaxis-susceptible strains, even before allergic sensitization. In a forward gen...
• Study used DNA from thousands-without consent AI翻译
  作者：Inampudi, Annika
• Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to ingested antigens AI翻译
  作者：Bachtel, Nathaniel D.; Cullen, Jaime L.; Liu, Min; Erickson, Steven A.; Kutyavin, Vassily I.; El-Naccache, Darine W.; Florsheim, Esther B.; Lim, Jaechul; Sullivan, Zuri A.; Imaeda, Raiden; Hudak, Andrew; Zhang, Cuiling; Medzhitov, Ruslan
  作者单位：Yale University; Arizona State University; Arizona State University-Tempe; Seoul National University (SNU); Seoul National University (SNU); Harvard University; Howard Hughes Medical Institute; Yale University; AstraZeneca
  摘要：Anaphylaxis is a life-threatening complication of food allergen exposure. Although mechanisms governing anaphylaxis after intravenous injection are defined in mice, these models neglect mucosal exposure that accompanies ingestion. We investigated the role of mast cells within the intestine of mice and found that oral anaphylaxis required immunoglobulin E-Fc epsilon receptor 1 (IgE-Fc epsilon R1) signaling. Intestinal mast cells were a heterogeneous population, shaped by epithelial cues. Compar...
• Community support for inclusive US education AI翻译
  作者：Driessen, Emily P.; Lane, A. Kelly
  作者单位：University of Minnesota System; University of Minnesota Twin Cities