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作者：Ross, Sarah; Ash, Caroline
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作者：Nowakowski, Krystian; Agarwal, Hitesh; Slizovskiy, Sergey; Smeyers, Robin; Wang, Xueqiao; Zheng, Zhiren; Barrier, Julien; Barcons Ruiz, David; Li, Geng; Bertini, Riccardo; Ceccanti, Matteo; Torre, Iacopo; Jorissen, Bert; Reserbat-Plantey, Antoine; Watanabe, Kenji; Taniguchi, Takashi; Covaci, Lucian; Milosevic, Milorad V.; Falko, Vladimir; Jarillo-Herrero, Pablo; Krishna Kumar, Roshan; Koppens, Frank H. L.
作者单位：Barcelona Institute of Science & Technology; Universitat Politecnica de Catalunya; Institut de Ciencies Fotoniques (ICFO); University of Manchester; University of Antwerp; University of Antwerp; Massachusetts Institute of Technology (MIT); Universitat Politecnica de Catalunya; Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); National Institute for Materials Science; National Institute for Materials Science; Barcelona Institute of Science & Technology; Catalan Institute of Nanoscience & Nanotechnology (ICN2); Consejo Superior de Investigaciones Cientificas (CSIC); Barcelona Institute of Science & Technology; ICREA
摘要：Detecting individual light quanta is essential for quantum information, space exploration, advanced machine vision, and fundamental science. In this work, we introduce a single-photon detection mechanism using highly photosensitive nonequilibrium electron phases in moir & eacute; materials. Using tunable bands in bilayer graphene/hexagonal boron nitride superlattices, we engineer negative differential conductance and a sensitive bistable state capable of detecting single photons. Operating in ...
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作者：Weidlich, Emanuela W. A.
作者单位：Leuphana University Luneburg
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作者：Metcalf, C. Jessica E.; Graham, Andrea L.; Yates, Andrew J.; Cummings, Derek A. T.
作者单位：Princeton University; Princeton University; The Santa Fe Institute; Columbia University; NewYork-Presbyterian Hospital; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Johns Hopkins University
摘要：Three ingredients create the strikingly variable immune trajectories observed across human populations: (i) genetic variation, (ii) individual-scale generation of additional genetic diversity solely in lymphocytes, and (iii) collision of these processes with a changing environment through life, triggering plastic responses that can have lasting effects. We explore what generates or reduces immune variation, integrating recent empirical advances with potential overarching evolutionary principle...
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作者：Sharma, Sonia; Gibbons, Alicia; Saphire, Erica Ollmann
作者单位：La Jolla Institute for Immunology; RIKEN; University of California System; University of California San Diego
摘要：Biological sex exerts a substantial influence on the immune system and immune-related diseases. Males are more susceptible to the acute effects of viral disease and certain cancers, whereas females exhibit a more robust immune response that can make them prone to developing autoimmune complications. We reflect on the emerging appreciation of sex differences-governed by genetics, sex hormones, and environmental factors-in tissue immunity and immunology. Understanding these tissue context-depend...
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作者：Haque, Tamara T.; Kaplan, Mark H.
作者单位：Indiana University System; Indiana University Indianapolis; Indiana University System; Indiana University Indianapolis
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作者：Pizzo, Michelle E.; Plowey, Edward D.; Khoury, Nathalie; Kwan, Wanda; Abettan, Jordan; DeVos, Sarah L.; Discenza, Claire B.; Earr, Timothy; Joy, David; Lye-Barthel, Ming; Roche, Elysia; Chan, Darren; Dugas, Jason C.; Gadkar, Kapil; Hamann, Stefan; Meisner, Rene; Sebalusky, Jennifer; Silva Amaral, Ana Claudia; Becerra, Isabel; Chau, Roni; Chow, Johann; Clemens, Allisa J.; Dennis, Mark S.; Duque, Joseph; Fusaro, Laura; Getz, Jennifer A.; Kariolis, Mihalis S.; Kim, Do Jin; Lechtenberg, Kendra J.; Leung, Amy Wing-Sze; Moshkforoush, Arash; Nguyen, Hoang N.; Ojo, Emmanuel S.; Thomsen, Elliot R.; Torres, Vanessa O.; Sanchez, Pascal E.; Shan, Lu; Silverman, Adam P.; Sweeney, Zachary K.; Solanoy, Hilda; Tong, Raymond; Calvert, Meredith E.; Watts, Ryan J.; Thorne, Robert G.; Weinreb, Paul H.; Walsh, Dominic M.; Lewcock, Joseph W.; Bussiere, Thierry; Zuchero, Y. Joy Yu
作者单位：Biogen; University of Minnesota System; University of Minnesota Twin Cities
摘要：Amyloid-related imaging abnormalities (ARIA), side effects of anti-amyloid drugs seen in magnetic resonance imaging of the brain, are a major safety concern in patients with Alzheimer's disease. We developed an antibody transport vehicle (ATV) targeting transferrin receptor (TfR) for brain delivery of anti-amyloid-beta protein (anti-A beta) using asymmetrical Fc mutations (ATVcisLALA) that mitigates TfR-related liabilities and retains effector function when bound to A beta. Administration of A...
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作者：Richard, Benoit; Boll, Rebecca; Banerjee, Sourav; Schaefer, Julia M.; Jurek, Zoltan; Kastirke, Gregor; Fehre, Kilian; Schoeffler, Markus S.; Anders, Nils; Baumann, Thomas M.; Eckart, Sebastian; Erk, Benjamin; De Fanis, Alberto; Doerner, Reinhard; Grundmann, Sven; Grychtol, Patrik; Hofmann, Max; Ilchen, Markus; Kircher, Max; Kubicek, Katharina; Kunitski, Maksim; Li, Xiang; Mazza, Tommaso; Meister, Severin; Melzer, Niklas; Montano, Jacobo; Music, Valerija; Ovcharenko, Yevheniy; Passow, Christopher; Pier, Andreas; Rennhack, Nils; Rist, Jonas; Rivas, Daniel E.; Rolles, Daniel; Schlichting, Ilme; Schmidt, Lothar Ph. H.; Schmidt, Philipp; Trabert, Daniel; Trinter, Florian; Wagner, Rene; Walter, Peter; Ziolkowski, Pawel; Rudenko, Artem; Meyer, Michael; Santra, Robin; Inhester, Ludger; Jahnke, Till
作者单位：Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); University of Hamburg; University of Hamburg; European XFEL; University of Hamburg; Goethe University Frankfurt; Helmholtz Association; GSI Helmholtz-Center for Heavy Ion Research; Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); Kansas State University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Max Planck Society; Universitat Kassel; Universitat Kassel; Max Planck Society; Max Planck Society; Fritz Haber Institute of the Max Planck Society
摘要：Because of the Heisenberg uncertainty principle, the structure of a molecule fluctuates about its mean geometry, even in the ground state. Observing this fundamental quantum effect experimentally-particularly, revealing the collective nature of the structural quantum fluctuations-remains an unmet challenge for complex molecules. In this work, we achieved this for an 11-atom molecule by inducing its Coulomb explosion with an x-ray free-electron laser. We show that the structural fluctuations ma...
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作者：Thorp, H. Holden
作者单位：Columbia University
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作者：Enserink, Martin
