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6760期

Science is a leading outlet for scientific news, commentary, and cutting-edge research. Through its print and online incarnations, Science reaches an estimated worldwide readership of more than one million. Science’s authorship is global too, and its articles consistently rank among the world's most cited research. Science seeks to publish those papers that are most influential in their fields or across fields and that will significantly advance

主办单位: AMER ASSOC ADVANCEMENT SCIENCE
期刊语言: 英语
创刊时间: 1880年
出版周期: 周刊
国际电子刊号: 1095-9203
影响因子: 41.846

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    摘要：The membrane skeleton in neurons adopts a periodic lattice structure in which actin filaments, capped by adducin and tropomodulin, form ring-shaped structures connected by spectrin tetramers along neurites. This membrane-associated periodic skeleton (MPS) is important for many neuronal functions. Using live-cell super-resolution imaging, we found that the MPS is surprisingly dynamic, undergoing local disassembly and reformation constitutively in axons. MPS remodeling is driven by calcium signa...